Search Results - "Santini, M A"

Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist by Swaney, J S, Chapman, C, Correa, L D, Stebbins, K J, Broadhead, A R, Bain, G, Santini, A M, Darlington, J, King, C D, Baccei, C S, Lee, C, Parr, T A, Roppe, J R, Seiders, T J, Ziff, J, Prasit, P, Hutchinson, J H, Evans, J F, Lorrain, D S

“…Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at least six G protein-coupled receptors designated LPA₁₋₆. LPA type 1…”
Get more information

Changes in 5-HT2A -mediated behavior and 5-HT2A - and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice by Klein, A.B, Santini, M.A, Aznar, S, Knudsen, G.M, Rios, M

“…Abstract Changes in brain-derived neurotrophic factor (BDNF) expression have been implicated in the etiology of psychiatric disorders. To investigate…”
Get full text

Novelty-induced activity-regulated cytoskeletal-associated protein ( Arc ) expression in frontal cortex requires serotonin 2A receptor activation by Santini, M.A, Klein, A.B, El-Sayed, M, Ratner, C, Knudsen, G.M, Mikkelsen, J.D, Aznar, S

“…Abstract Many psychiatric disorders are characterized by cognitive and emotional alterations that are related to abnormal function of the frontal cortex (FC)…”
Get full text

Pharmacodynamics and Pharmacokinetics of AM103, a Novel Inhibitor of 5-Lipoxygenase-Activating Protein ( ) by Bain, G, King, C D, Rewolinski, M, Schaab, K, Santini, A M, Shapiro, D, Moran, M, Wetering de Rooij, S, Roffel, A F, Schuilenga‐Hut, P, Milne, G L, Lorrain, D S, Li, Y, Arruda, J M, Hutchinson, J H, Prasit, P, Evans, J F

“…The 5‐lipoxygenase‐activating protein (FLAP) gene and an increase in leukotriene (LT) production are linked to the risk of asthma, myocardial infarction, and…”
Get full text

A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model by Swaney, J S, Chapman, C, Correa, L D, Stebbins, K J, Bundey, R A, Prodanovich, P C, Fagan, P, Baccei, C S, Santini, A M, Hutchinson, J H, Seiders, T J, Parr, T A, Prasit, P, Evans, J F, Lorrain, D S

“…The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA(1), in treating lung fibrosis We…”
Get full text

5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains by Klein, A.B, Ultved, L, Adamsen, D, Santini, M.A, Tobeña, A, Fernandez-Teruel, A, Flores, P, Moreno, M, Cardona, D, Knudsen, G.M, Aznar, S, Mikkelsen, J.D

“…Highlights • Roman Low- and High-Avoidance (RLA and RHA) rats differ in 5-HT2A R binding. • 5-HT2A R binding correlated with impulsivity in RHA rats. • SERT…”
Get full text

Compressive Strength and Microstructure of Alkali-Activated Blast Furnace Slag/Sewage Sludge Ash (GGBS/SSA) Blends Cured at Room Temperature by Tashima, M. M., Reig, L., Santini, M. A., B Moraes, J. C., Akasaki, J. L., Payá, J., Borrachero, M. V., Soriano, L.

“…In the present work, ground granulated blast furnace slag (GGBS) and sewage sludge ash (SSA) blends were assessed for the production of alkali-activated pastes…”
Get full text

A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model by Swaney, JS, Chapman, C, Correa, LD, Stebbins, KJ, Bundey, RA, Prodanovich, PC, Fagan, P, Baccei, CS, Santini, AM, Hutchinson, JH, Seiders, TJ, Parr, TA, Prasit, P, Evans, JF, Lorrain, DS

“…Background and purpose:  The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA1, in treating…”
Get full text

A novel, orally active LPA 1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model by Swaney, JS, Chapman, C, Correa, LD, Stebbins, KJ, Bundey, RA, Prodanovich, PC, Fagan, P, Baccei, CS, Santini, AM, Hutchinson, JH, Seiders, TJ, Parr, TA, Prasit, P, Evans, JF, Lorrain, DS

“…Background and purpose:  The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA 1 , in…”
Get full text

The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex by Menezes, M. M., Santini, M. A., Benvenga, M. J., Marek, G. J., Merchant, K. M., Mikkelsen, J. D., Svensson, K. A.

“…Metabotropic glutamate 2/3 (mGlu2/3) receptors have emerged as potential therapeutic targets due to the ability of mGlu2/3 receptor agonists to modulate…”
Get full text

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis by Bain, Gretchen, Shannon, Kristen E, Huang, Fei, Darlington, Janice, Goulet, Lance, Prodanovich, Patricia, Ma, Gina L, Santini, Angelina M, Stein, Adam J, Lonergan, Dave, King, Christopher D, Calderon, Imelda, Lai, Andiliy, Hutchinson, John H, Evans, Jilly F

“…Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the…”
Get more information

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding by Stein, Adam J, Bain, Gretchen, Prodanovich, Pat, Santini, Angelina M, Darlington, Janice, Stelzer, Nina M P, Sidhu, Ranjinder S, Schaub, Jeffrey, Goulet, Lance, Lonergan, Dave, Calderon, Imelda, Evans, Jilly F, Hutchinson, John H

“…Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA is a bioactive phospholipid that regulates…”
Get more information

Knowledge on sexually transmitted infections and AIDS of women who have sex with women by Parenti, A B H, Ignacio, M A O, Buesso, T S, Santini, M A, Cerqueira, A T A R, Nunes, H R C, Duarte, M T C

“…Introduction Literature points to a scarcity of studies on sexual health and risk behavior of women who have sex with women (WSW) living in low- and…”
Get full text

BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures by Trajkovska, V., Santini, M.A., Marcussen, A.B., Thomsen, M.S., Hansen, H.H., Mikkelsen, J.D., Arneberg, L., Kokaia, M., Knudsen, G.M., Aznar, S.

“…Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT2A) have been related to depression pathology. Specific 5-HT2A receptor…”
Get full text

Gestational Diabetes Mellitus and Risk Factors Associated with Urinary Incontinence in Pregnancy by Dias, A., Santini, A. C. M., Vianna, L. S., Assis, L. C., Dias, G. A.

Get full text

Risk Factors of Carpal Tunnel Syndrome in Pregnancy by Dias, G. A., Santini, A. C. M., Vianna, L. S., Santos, E. S., Dias, A.

Get full text

Associated Factors with Low Back Pain in Pregnant Women by Vianna, L. S., Santini, A. C. M., Dias, G. A., Santos, E. S., Assis, L. C., Dias, A.

Get full text

5-HT(2A) and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains by Klein, A B, Ultved, L, Adamsen, D, Santini, M A, Tobeña, A, Fernandez-Teruel, A, Flores, P, Moreno, M, Cardona, D, Knudsen, G M, Aznar, S, Mikkelsen, J D

“…The Roman Low- and High-Avoidance rat strains (RLA-I vs RHA-I) have been bidirectionally selected and bred according to their performance in the two-way active…”
Get full text

Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional BDNF knock-out mice by Klein, AB, Santini, MA, Aznar, S, Knudsen, GM, Rios, M

“…Changes in brain-derived neurotrophic factor (BDNF) expression have been implicated in the etiology of psychiatric disorders. To investigate pathological…”
Get full text

Italian validation of the International Consultation on Incontinence Questionnaires by TUBARO, ANDREA, ZATTONI, FILIBERTO, PREZIOSO, DOMENICO, SCARPA, ROBERTO M., PESCE, FRANCESCO, RIZZI, CARLO A., SANTINI, AMBRA M., SIMONI, LUCIA, ARTIBANI, WALTER

“…OBJECTIVE To validate the Italian version of two questionnaires for lower urinary tract symptoms (LUTS), i.e. the long (LF) and the short form (SF) of the…”
Get full text