Search Results - "Santich, Brian H"

A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency by Zhou, Qing, Lee, Geun-Shik, Brady, Jillian, Datta, Shrimati, Katan, Matilda, Sheikh, Afzal, Martins, Marta S, Bunney, Tom D, Santich, Brian H, Moir, Susan, Kuhns, Douglas B, Long Priel, Debra A, Ombrello, Amanda, Stone, Deborah, Ombrello, Michael J, Khan, Javed, Milner, Joshua D, Kastner, Daniel L, Aksentijevich, Ivona

“…Whole-exome sequencing was performed in a family affected by dominantly inherited inflammatory disease characterized by recurrent blistering skin lesions,…”
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Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals by Kardava, Lela, Moir, Susan, Shah, Naisha, Wang, Wei, Wilson, Richard, Buckner, Clarisa M, Santich, Brian H, Kim, Leo J Y, Spurlin, Emily E, Nelson, Amy K, Wheatley, Adam K, Harvey, Christopher J, McDermott, Adrian B, Wucherpfennig, Kai W, Chun, Tae-Wook, Tsang, John S, Li, Yuxing, Fauci, Anthony S

“…Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. Despite extensive evidence of B cell…”
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Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release by Park, Jeong A, Santich, Brian H, Xu, Hong, Lum, Lawrence G, Cheung, Nai-Kong V

“…BackgroundT cell-based immunotherapies using chimeric antigen receptors (CAR) or bispecific antibodies (BsAb) have produced impressive responses in…”
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Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma by Long, Alan W, Xu, Hong, Santich, Brian H, Guo, Hongfen, Hoseini, Sayed Shahabuddin, de Stanchina, Elisa, Cheung, Nai-Kong V

“…EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR or HER2xHER2) and heterodimeric…”
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Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy by Goswami, Meghali, Prince, Gabrielle, Biancotto, Angelique, Moir, Susan, Kardava, Lela, Santich, Brian H, Cheung, Foo, Kotliarov, Yuri, Chen, Jinguo, Shi, Rongye, Zhou, Huizhi, Golding, Hana, Manischewitz, Jody, King, Lisa, Kunz, Lauren M, Noonan, Kimberly, Borrello, Ivan M, Smith, B Douglas, Hourigan, Christopher S

“…Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study…”
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Editorial: Bispecific Antibodies for T-Cell Based Immunotherapy by Santich, Brian H, Cheung, Nai-Kong V, Klein, Christian

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TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies by Ahmed, Mahiuddin, Lopez-Albaitero, Andres, Pankov, Dmitry, Santich, Brian H, Liu, Hong, Yan, Su, Xiang, Jingyi, Wang, Pei, Hasan, Aisha N, Selvakumar, Annamalai, O'Reilly, Richard J, Liu, Cheng, Cheung, Nai-Kong V

“…EBV infection is associated with a number of malignancies of clinical unmet need, including Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and…”
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Protection from secondary dengue virus infection in a mouse model reveals the role of serotype cross-reactive B and T cells by Zompi, Simona, Santich, Brian H, Beatty, P Robert, Harris, Eva

“…The four dengue virus (DENV) serotypes cause dengue fever and dengue hemorrhagic fever/dengue shock syndrome. Although severe disease has been associated with…”
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A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy by Santich, Brian H, Cheal, Sarah M, Ahmed, Mahiuddin, McDevitt, Michael R, Ouerfelli, Ouathek, Yang, Guangbin, Veach, Darren R, Fung, Edward K, Patel, Mitesh, Burnes Vargas, Daniela, Malik, Aiza A, Guo, Hong-Fen, Zanzonico, Pat B, Monette, Sebastien, Michel, Adam O, Rudin, Charles M, Larson, Steven M, Cheung, Nai K

“…Many cancer treatments suffer from dose-limiting toxicities to vital organs due to poor therapeutic indices. To overcome these challenges we developed a novel…”
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Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection by Cubas, Rafael, van Grevenynghe, Julien, Wills, Saintedym, Kardava, Lela, Santich, Brian H, Buckner, Clarisa M, Muir, Roshell, Tardif, Virginie, Nichols, Carmen, Procopio, Francesco, He, Zhong, Metcalf, Talibah, Ghneim, Khader, Locci, Michela, Ancuta, Petronella, Routy, Jean-Pierre, Trautmann, Lydie, Li, Yuxing, McDermott, Adrian B, Koup, Rick A, Petrovas, Constantinos, Migueles, Steven A, Connors, Mark, Tomaras, Georgia D, Moir, Susan, Crotty, Shane, Haddad, Elias K

“…Despite the overwhelming benefits of antiretroviral therapy (ART) in curtailing viral load in HIV-infected individuals, ART does not fully restore cellular and…”
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Intraperitoneal Pretargeted Radioimmunotherapy for Colorectal Peritoneal Carcinomatosis by Chandler, Christopher S, Bell, Meghan M, Chung, Sebastian K, Veach, Darren R, Fung, Edward K, Punzalan, Blesida, Burnes Vargas, Daniela, Patel, Mitesh, Xu, Hong, Guo, Hong-Fen, Santich, Brian H, Zanzonico, Pat B, Monette, Sébastien, Nash, Garrett M, Cercek, Andrea, Jungbluth, Achim, Pandit-Taskar, Neeta, Cheung, Nai Kong V, Larson, Steven M, Cheal, Sarah M

“…Peritoneal carcinomatosis (PC) is considered incurable, and more effective therapies are needed. Herein we test the hypothesis that GPA33-directed…”
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Engineered Cells as a Test Platform for Radiohaptens in Pretargeted Imaging and Radioimmunotherapy Applications by Dacek, Megan M, Veach, Darren R, Cheal, Sarah M, Carter, Lukas M, McDevitt, Michael R, Punzalan, Blesida, Burnes Vargas, Daniela, Kubik, Thomas Z, Monette, Sebastien, Santich, Brian H, Yang, Guangbin, Ouerfelli, Ouathek, Kesner, Adam L, Cheung, Nai-Kong V, Scheinberg, David A, Larson, Steven M, Krebs, Simone

“…Pretargeted imaging and radioimmunotherapy approaches are designed to have superior targeting properties over directly targeted antibodies but impose more…”
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Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors by Cheng, Ming, Santich, Brian H., Xu, Hong, Ahmed, Mahiuddin, Huse, Morgan, Cheung, Nai-Kong V.

“…Engineering potent bispecific antibodies from single-chain variable fragments (scFv) remains difficult due to the inherent instability and insufficient binding…”
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Targeting Intracellular Antigens with pMHC-Binding Antibodies: A Phage Display Approach by Wu, Zhihao, Santich, Brian H, Liu, Hong, Liu, Cheng, Cheung, Nai-Kong V

“…Antibodies that bind peptide-MHC (pMHC) complex in a manner akin to T-cell receptor (TCR) have not only helped in understanding the mechanism of TCR-pMHC…”
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Gravesʹ disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4+ T-cell recovery by SHEIKH, Virginia, DERSIMONIAN, Rebecca, MOIR, Susan, SERETI, Irini, RICHTERMAN, Aaron G, PORTER, Brian O, NATARAJAN, Ven, BURBELO, Peter D, RUPERT, Adam, SANTICH, Brian H, KARDAVA, Lela, MICAN, JoAnn M

“…Immune restoration disease (IRD) can develop in HIV-infected patients following antiretroviral therapy (ART) initiation as unmasking or paradoxical worsening…”
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Generation of TCR-Like Antibodies Using Phage Display by Santich, Brian H, Liu, Hong, Liu, Cheng, Cheung, Nai-Kong V

“…The adaptive immune response against cancer consists of two arms: the humoral response from B cells, and the cell-mediated response from T cells. The humoral…”
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Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells by Moir, Susan, De Ravin, Suk See, Santich, Brian H., Kim, Jin Young, Posada, Jacqueline G., Ho, Jason, Buckner, Clarisa M., Wang, Wei, Kardava, Lela, Garofalo, Mary, Marciano, Beatriz E., Manischewitz, Jody, King, Lisa R., Khurana, Surender, Chun, Tae-Wook, Golding, Hana, Fauci, Anthony S., Malech, Harry L.

“…CD27+ memory B cells are reduced in the blood of patients with chronic granulomatous disease (CGD) for reasons and consequences that remain unclear. Here we…”
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Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals by Montezuma-Rusca, Jairo M, Moir, Susan, Kardava, Lela, Buckner, Clarisa M, Louie, Aaron, Kim, Leo J Y, Santich, Brian H, Wang, Wei, Fankuchen, Olivia R, Diaz, Gabriella, Daub, Janine R, Rosenzweig, Sergio D, Chun, Tae-Wook, Li, Yuxing, Braylan, Raul C, Calvo, Katherine R, Fauci, Anthony S

“…Several potent and broadly neutralizing Abs to HIV-1 have been isolated recently from peripheral blood B cells of infected individuals, based on prescreening…”
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Alpha radioimmunotherapy using 225 Ac-proteus-DOTA for solid tumors - safety at curative doses by Cheal, Sarah M, McDevitt, Michael R, Santich, Brian H, Patel, Mitesh, Yang, Guangbin, Fung, Edward K, Veach, Darren R, Bell, Meghan, Ahad, Afruja, Vargas, Daniela Burnes, Punzalan, Blesida, Pillarsetty, Naga Vara Kishore, Xu, Hong, Guo, Hong-Fen, Monette, Sébastien, Michel, Adam O, Piersigilli, Alessandra, Scheinberg, David A, Ouerfelli, Ouathek, Cheung, Nai-Kong V, Larson, Steven M

“…This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using Ac and its theranostic pair, In. We call our novel tumor-targeting…”
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CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation by Buckner, Clarisa M., PhD, Moir, Susan, PhD, Kardava, Lela, PhD, Ho, Jason, PhD, Santich, Brian H., BA, Kim, Leo Jin Young, BA, Funk, Emily K., BA, Nelson, Amy K., BSN, Winckler, Britanny, BA, Chairez, Cheryl L., BSN, Theobald-Whiting, Narda L., BS, Anaya-O’Brien, Sandra, MSN, Alimchandani, Meghna, MD, Quezado, Martha M., MD, Yao, Michael D., MD, Kovacs, Joseph A., MD, Chun, Tae-Wook, PhD, Fauci, Anthony S., MD, Malech, Harry L., MD, De Ravin, Suk See, MD, PhD

“…Background We previously reported abnormalities in circulating B cells in patients with chronic granulomatous disease (CGD) and those with HIV infection…”
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