Search Results - "Santiago, V."
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International consensus on the assessment of bruxism: Report of a work in progress
Published in Journal of oral rehabilitation (01-11-2018)“…Summary In 2013, consensus was obtained on a definition of bruxism as repetitive masticatory muscle activity characterised by clenching or grinding of the…”
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Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization
Published in Chemical reviews (26-08-2015)“…The results of a study on synthesis of macrocyclic structures, with an emphasis on the conditions of concentration, temperature, and yields, are presented…”
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Tracking a mass mortality outbreak of pen shell Pinna nobilis populations: A collaborative effort of scientists and citizens
Published in Scientific reports (16-09-2019)“…A mass mortality event is devastating the populations of the endemic bivalve Pinna nobilis in the Mediterranean Sea from early autumn 2016. A newly described…”
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Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease
Published in Biochemical and biophysical research communications (19-02-2017)“…Soluble oligomers of amyloid-beta (Aβo) are implicated by biochemical and genetic evidence as a trigger for Alzheimer's disease (AD) pathophysiology. A key…”
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Is bruxism a disorder or a behaviour? Rethinking the international consensus on defining and grading of bruxism
Published in Journal of oral rehabilitation (01-10-2016)“…Summary Inspired by the international consensus on defining and grading of bruxism (Lobbezoo F, Ahlberg J, Glaros AG, Kato T, Koyano K, Lavigne GJ et al. J…”
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Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
Published in Annals of neurology (01-06-2015)“…Objective Currently no effective disease‐modifying agents exist for the treatment of Alzheimer disease (AD). The Fyn tyrosine kinase is implicated in AD…”
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Bioinspired Chemistry Based on Minimalistic Pseudopeptides
Published in Accounts of chemical research (21-01-2014)“…For years researchers have tried to understand the molecular behavior of complex biomolecules through the development of small molecules that can partially…”
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Aryl versus Alkyl Redox-Active Diazoacetates Light-Induced C–H Insertion or 1,2-Rearrangement
Published in Organic letters (01-09-2023)“…Diazo compounds with redox-active leaving groups are versatile reagents for orthogonal functionalizations, previously utilized in the Rh-catalyzed synthesis of…”
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Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss
Published in The Journal of neuroscience (06-03-2019)“…The intracellular tyrosine kinase Pyk2 (PTK2B) is related to focal adhesion kinase and localizes to postsynaptic sites in brain. Pyk2 genetic variation…”
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Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease
Published in Brain (London, England : 1878) (01-02-2016)“…Alzheimer's disease-related phenotypes in mice can be rescued by blockade of either cellular prion protein or metabotropic glutamate receptor 5. We sought…”
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Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss
Published in The Journal of neuroscience (23-01-2019)“…Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons. Here, we show that the…”
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12
Climate-regulation services of natural and agricultural ecoregions of the Americas
Published in Nature climate change (01-03-2012)“…This study combines previous work on quantifying the greenhouse gas value of ecosystems with models of the effects of biophysical processes to produce an…”
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The key role of pretreatment for the one-step and multi-step conversions of European lignocellulosic materials into furan compounds
Published in RSC advances (12-07-2023)“…Nowadays, an increased interest from the chemical industry towards the furanic compounds production, renewable molecules alternatives to fossil molecules,…”
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Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes
Published in Cell reports (Cambridge) (05-07-2017)“…Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer’s disease (AD) pathology. We sought to understand whether mGluR5’s role in AD…”
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Precipitation diurnal cycle and summer climatology assessment over South America: An evaluation of Regional Climate Model version 3 simulations
Published in Journal of Geophysical Research - Atmospheres (27-05-2009)“…Regional Climate Model version 3 (RegCM3) simulations of 17 summers (1988–2004) over part of South America south of 5°S were evaluated to identify model…”
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Continuous Flow Processes as an Enabling Tool for the Synthesis of Constrained Pseudopeptidic Macrocycles
Published in Journal of organic chemistry (04-03-2022)“…Herein we report our efforts to develop a continuous flow methodology for the efficient preparation of pseudopeptidic macrocyclic compounds containing the…”
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Pseudopeptidic fluorescent on-off pH sensor based on pyrene excimer emission: Imaging of acidic cellular organelles
Published in Sensors and actuators. B, Chemical (29-10-2016)“…[Display omitted] A pseudopeptidic compound comprising a central C2 symmetric bis(aminoamide) moiety derived from the amino acid serine and two pyrene groups…”
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Pioneering women of microbiology in Spain
Published in International microbiology (01-11-2020)“…Presented herein are the trajectories of four women who can be considered pioneers of microbiology in Spain. Three of them have been studied before, but never…”
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Generalizations, formulations and subgradient based heuristic with dynamic programming procedure for target set selection problems
Published in Computers & operations research (01-11-2021)“…Target set selection problems model influence processes through networks. Usually, these problems seek a set of individuals to be initially influenced by some…”
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Imidazole and Imidazolium Antibacterial Drugs Derived from Amino Acids
Published in Pharmaceuticals (Basel, Switzerland) (21-12-2020)“…The antibacterial activity of imidazole and imidazolium salts is highly dependent upon their lipophilicity, which can be tuned through the introduction of…”
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