Search Results - "Santiago, Mafalda"

Tet3 regulates cellular identity and DNA methylation in neural progenitor cells by Santiago, Mafalda, Antunes, Claudia, Guedes, Marta, Iacovino, Michelina, Kyba, Michael, Reik, Wolf, Sousa, Nuno, Pinto, Luísa, Branco, Miguel R., Marques, C. Joana

“…TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), a process thought to be intermediary in an active DNA demethylation mechanism…”
Get full text

TET enzymes and DNA hydroxymethylation in neural development and function — How critical are they? by Santiago, Mafalda, Antunes, Claudia, Guedes, Marta, Sousa, Nuno, Marques, C. Joana

“…Epigenetic modifications of the genome play important roles in controlling gene transcription thus regulating several molecular and cellular processes. A novel…”
Get full text

A scoping review on early inflammatory bowel disease: definitions, pathogenesis, and impact on clinical outcomes by Estevinho, Maria Manuela, Leão Moreira, Paula, Silva, Isabel, Laranjeira Correia, João, Santiago, Mafalda, Magro, Fernando

“…Background: Crohn’s disease (CD) and ulcerative colitis (UC) arise from a dysregulation of the balance between commensal microbiota and mucosal-associated…”
Get full text

Correction to: Tet3 regulates cellular identity and DNA methylation in neural progenitor cells by Santiago, Mafalda, Antunes, Claudia, Guedes, Marta, Iacovino, Michelina, Kyba, Michael, Reik, Wolf, Sousa, Nuno, Pinto, Luísa, Branco, Miguel R., Marques, C. Joana

“…The article Tet3 regulates cellular identity and DNA methylation in neural progenitor cells, written by Miguel R. Branco and C. Joana Marques, was originally…”
Get full text

What forecasting the prevalence of inflammatory bowel disease may tell us about its evolution on a national scale by Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, Dias, Cláudia Camila

“…Inflammatory bowel disease (IBD) is increasingly prevalent within western societies. Its complex and chronic facets in addition to its increasing prevalence…”
Get full text

Incidence Trends of Inflammatory Bowel Disease in a Southern European Country: A Mirror of the Western World? by Santiago, Mafalda, Stocker, Francisco, Ministro, Paula, Gonçalves, Raquel, Carvalho, Diana, Portela, Francisco, Correia, Luís, Lago, Paula, Trindade, Eunice, Dias, Cláudia Camila, Magro, Fernando

“…Inflammatory bowel disease (IBD) affects people from all age categories worldwide. Although the incidence of the disease is stabilizing or decreasing in most…”
Get full text

Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis by Magro, Fernando, Sottomayor, Catarina, Alves, Catarina, Santiago, Mafalda, Ministro, Paula, Lago, Paula, Correia, Luís, Gonçalves, Raquel, Carvalho, Diana, Portela, Francisco, Dias, Cláudia Camila, Dignass, Axel, Danese, Silvio, Peyrin-Biroulet, Laurent, Estevinho, Maria Manuela, Leão Moreira, Paula

“…Background: This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn’s disease and to…”
Get full text

Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: a 16-year nationwide study by Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, Trindade, Eunice, Dias, Cláudia Camila

“…Aims: We aimed to describe the burden of rehospitalization in patients with inflammatory bowel disease (IBD), by evaluating rehospitalization rates, charges,…”
Get full text

Viable Mycobacterium avium subsp. paratuberculosis Colonizes Peripheral Blood of Inflammatory Bowel Disease Patients by Estevinho, Maria Manuela, Cabeda, José, Santiago, Mafalda, Machado, Elisabete, Silva, Ricardo, Duro, Mary, Pita, Inês, Morais, Rui, Macedo, Guilherme, Bull, Tim J, Magro, Fernando, Sarmento, Amélia

“…Pathobionts, particularly subsp. (MAP) and isolates with adherence/invasive ability (AIEC) have been associated with inflammatory bowel disease (IBD),…”
Get full text

Inflammatory Bowel Disease Reoperation Rate Has Decreased Over Time If Corrected by Prevalence by Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, Trindade, Eunice, Dias, Cláudia Camila

“…Despite the recent emergence of expensive biologic therapies, hospitalization and surgery remain important contributors for the overall costs of inflammatory…”
Get full text

The workup process of vaccination in IBD patients needs a change—Insights from a multinational survey by Abreu, Candida, Monteiro, Carolina, Santiago, Mafalda, Sarmento, Antonio, Magro, Fernando

“…Immunosuppressive medications play a crucial role in inflammatory bowel disease (IBD) but increase susceptibility to infections, underlining the importance of…”
Get full text

Impact of Crohn's Disease Therapies on Histology in Randomized Controlled Trials: Systematic Review With Meta-analysis by Roseira, Joana, Santiago, Mafalda, Estevinho, Maria Manuela, Moreira, Paula, Alves, Catarina, Danese, Silvio, Peyrin-Biroulet, Laurent, Dignass, Axel, Feakins, Roger, Magro, Fernando

“…The effectiveness of Crohn's disease treatments for inducing histological outcomes has not been addressed systematically. We performed a systematic review and…”
Get full text

The Magnitude of Crohn’s Disease Direct Costs in Health Care Systems (from Different Perspectives): A Systematic Review by Santiago, Mafalda, Dias, Cláudia Camila, Alves, Catarina, Ministro, Paula, Gonçalves, Raquel, Carvalho, Diana, Portela, Francisco, Correia, Luís, Lago, Paula, Magro, Fernando

“…Abstract Background The prevalence of inflammatory bowel disease (IBD) has been increasing worldwide, causing high impact on the quality of life of patients…”
Get full text

Dipeptidyl peptidase 4 (DPP4) in fecal samples: validation of the extraction methodology and stability in short-term storage conditions by Gomes, Sandra F, Melo, Francisco Jorge, Silva, Rita, Santiago, Mafalda, Estevinho, Maria Manuela, Dias, Sandra, Dias, Cláudia Camila, Magro, Fernando

“…This study assesses the clinical relevance of dipeptidyl peptidase 4 (DPP4) membrane exopeptidase as a biomarker of inflammatory bowel disease (IBD). A…”
Get more information

Mo1847 THE INFLUENCE OF PERSISTENT ACTIVE INFLAMMATION ON IFX PHARMACOKINETIC MODELING AND DISEASE PROGRESSION ASSESSMENT: FINDINGS FROM A PROSPECTIVE REAL-WORLD STUDY IN INFLAMMATORY BOWEL DISEASE PATIENTS by Magro, Fernando, Fernandes, Samuel R., Patita, Marta, Arroja, Bruno, Lago, Paula M., Rosa, Isadora, Sousa, Helena Tavares, Ministro, Paula, Mocanu, Irina, Vieira, Ana, Castela, Joana, Moleiro, Joana, Roseira, Joana, Cancela, Eugénia, Sousa, Paula, Portela, Francisco, Correia, Luís Araujo, Moreira, Paula, Afonso, Joana, Dias, Sandra, Danese, Silvio, Peyrin-Biroulet, Laurent, Vučićević, Katarina, Santiago, Mafalda

Get full text

Subclinical Persistent Inflammation as Risk Factor for Crohn's Disease Progression: Findings From a Prospective Real-World Study of 2 Years by Magro, Fernando, Magalhães, Diogo, Patita, Marta, Arroja, Bruno, Lago, Paula, Rosa, Isadora, Tavares de Sousa, Helena, Ministro, Paula, Mocanu, Irinia, Vieira, Ana, Castela, Joana, Moleiro, Joana, Roseira, Joana, Cancela, Eugénia, Sousa, Paula, Portela, Francisco, Correia, Luís, Santiago, Mafalda, Dias, Sandra, Alves, Catarina, Afonso, Joana, Danese, Silvio, Peyrin-Biroulet, Laurent, Dias, Claudia Camila

“…Subclinical intestinal inflammation is common in Crohn’s disease (CD). We aimed to explore its impact in the disease progression of infliximab-treated patients…”
Get full text

Hospitalization trends of the Inflammatory Bowel Disease landscape: A nationwide overview of 16 years by Dias, Cláudia Camila, Santiago, Mafalda, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, Trindade, Eunice, Freitas, Alberto, Magro, Fernando

“…In this study, we aimed to determine the hospitalization rates of Inflammatory Bowel Disease (IBD) in a southern-european country and its associated charges…”
Get full text

Sexual Quality of Life in Inflammatory Bowel Disease: A Multicenter, National-Level Study by Roseira, Joana, Magro, Fernando, Fernandes, Samuel, Simões, Carolina, Portela, Francisco, Vieira, Ana Isabel, Patita, Marta, Leal, Carina, Lago, Paula, Caldeira, Paulo, Gago, Tânia, Currais, Pedro, Dias, Cláudia Camila, Santiago, Mafalda, Dias, Sandra, Tavares de Sousa, Helena

“…Abstract Background The impact of inflammatory bowel disease (IBD) on sexual health is a leading concern among patients. Most studies focus on sexual…”
Get full text

Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 months of maintenance treatment with infliximab by Sousa, Paula, Patita, Marta, Arroja, Bruno, Lago, Paula, Rosa, Isadora, de Sousa, Helena Tavares, Ministro, Paula, Mocanu, Irina, Vieira, Ana, Castela, Joana, Moleiro, Joana, Roseira, Joana, Cancela, Eugenia, Portela, Francisco, Correia, Luis, Santiago, Mafalda, Dias, Sandra, Alves, Catarina, Afonso, Joana, Dias, Claudia Camila, Magro, Fernando

“…The emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines. To clarify the…”
Get full text

Histologic Features of Colon Biopsies (Geboes Score) Associated With Progression of Ulcerative Colitis for the First 36 Months After Biopsy by Magro, Fernando, Alves, Catarina, Lopes, Joanne, Lopes, Susana, Tavares de Sousa, Helena, Cotter, José, Macedo da Silva, Vitor, Lago, Paula, Vieira, Ana, Brito, Mariana, Duarte, Maria A.M., Portela, Francisco, Silva, João P., Ministro, Paula, Arroja, Bruno, Carvalho, Liliana, Torres, Joana, Santiago, Mafalda, Estevinho, Maria Manuela, Danese, Silvio, Peyrin-Biroulet, Laurent, Dias, Cláudia Camila, Borralho, Paula, Feakins, Roger M., Carneiro, Fátima

“…In addition to findings from endoscopy, histologic features of colon biopsies have been associated with outcomes of patients with ulcerative colitis (UC). We…”
Get full text