Search Results - "Santi, Claudio"

Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation by Santi, Claudio, Scimmi, Cecilia, Sancineto, Luca

“…Ebselen is the leader of selenorganic compounds, and starting from its identification as mimetic of the key antioxidant enzyme glutathione peroxidase, several…”
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Fluorine‐Containing Drugs Approved by the FDA in 2018 by Mei, Haibo, Han, Jianlin, Fustero, Santos, Medio‐Simon, Mercedes, Sedgwick, Daniel M., Santi, Claudio, Ruzziconi, Renzo, Soloshonok, Vadim A.

“…Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most…”
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A tribute to Prof. Lorenzo Testaferri by Santi, Claudio

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Celebrating Two Centuries of Research in Selenium Chemistry: State of the Art and New Prospective by Santi, Claudio, Bagnoli, Luana

“…In 2017, the 200th anniversary of the discovery of selenium was celebrated. In 1817, the Swedish chemists, Berzelius and Gahn, on roasting 200 kg of sulfur…”
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New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use by Benedetto Tiz, Davide, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Sancineto, Luca, Santi, Claudio

“…This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound)…”
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Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds by Santi, Micol, Sancineto, Luca, Nascimento, Vanessa, Braun Azeredo, Juliano, Orozco, Erika V M, Andrade, Leandro H, Gröger, Harald, Santi, Claudio

“…Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts in both industry and academia. In the last two decades, the…”
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New Insights into Green Protocols for Oxidative Depolymerization of Lignin and Lignin Model Compounds by Scimmi, Cecilia, Sancineto, Luca, Drabowicz, Jozef, Santi, Claudio

“…Oxidative depolymerization of lignin is a hot topic in the field of biomass valorization. The most recent and green procedures have been herein detailed…”
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Continuous Bioinspired Oxidation of Sulfides by Mangiavacchi, Francesca, Crociani, Letizia, Sancineto, Luca, Marini, Francesca, Santi, Claudio

“…A simple, efficient, and selective oxidation under flow conditions of sulfides into their corresponding sulfoxides and sulfones is reported herein, using as a…”
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"Green Is the Color": An Update on Ecofriendly Aspects of Organoselenium Chemistry by Azeredo, Juliano B, Penteado, Filipe, Nascimento, Vanessa, Sancineto, Luca, Braga, Antonio L, Lenardao, Eder João, Santi, Claudio

“…Organoselenium compounds have been successfully applied in biological, medicinal and material sciences, as well as a powerful tool for modern organic…”
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Vinylation of N-Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones by Palomba, Martina, Dias, Italo Franco Coelho, Cocchioni, Michelangelo, Marini, Francesca, Santi, Claudio, Bagnoli, Luana

“…A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and azoles in the presence of potassium hydroxide was developed. This reaction…”
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Suspect screening analysis to improve untargeted and targeted UHPLC-qToF approaches: the biodegradability of a proton pump inhibitor medicine and a natural medical device by Mattoli, Luisa, Proietti, Giacomo, Fodaroni, Giada, Quintiero, Claudio Marzio, Burico, Michela, Gianni, Mattia, Giovagnoni, Emiliano, Mercati, Valentino, Santi, Claudio

“…Suspect screening and untargeted analysis using UHPLC-qToF are two advanced analytical approaches now used to achieve an extensive chemical profile of samples,…”
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Synthesis of Spirooxindole Oxetanes Through a Domino Reaction of 3‐Hydroxyoxindoles and Phenyl Vinyl Selenone by Palomba, Martina, Scarcella, Elisabetta, Sancineto, Luca, Bagnoli, Luana, Santi, Claudio, Marini, Francesca

“…An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room…”
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Publisher Correction: Suspect screening analysis to improve untargeted and targeted UHPLC-qToF approaches: the biodegradability of a proton pump inhibitor medicine and a natural medical device by Mattoli, Luisa, Proietti, Giacomo, Fodaroni, Giada, Quintiero, Claudio Marzio, Burico, Michela, Gianni, Mattia, Giovagnoni, Emiliano, Mercati, Valentino, Santi, Claudio

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Catalytic Chalcogenylation under Greener Conditions: A Solvent-Free Sulfur- and Seleno-functionalization of Olefins via I2/DMSO Oxidant System by Vieira, André A, Azeredo, Juliano B, Godoi, Marcelo, Santi, Claudio, da Silva Júnior, Eufrânio N, Braga, Antonio L

“…Herein, we report a solvent- and metal-free methodology for the alkoxy-chalcogenylation of styrenes, using molecular iodine as a catalyst, DMSO as a…”
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Water Extracts from Industrial Hemp Waste Inhibit the Adhesion and Development of Candida Biofilm and Showed Antioxidant Activity on HT-29 Colon Cancer Cells by Donati, Leonardo, Casagrande Pierantoni, Debora, Conti, Angela, Calzoni, Eleonora, Corte, Laura, Santi, Claudio, Rosati, Ornelio, Cardinali, Gianluigi, Emiliani, Carla

“…The evolution of regulatory perspectives regarding the health and nutritional properties of industrial hemp-based products ( L.) has pushed research to focus…”
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Selenium Catalyzed Oxidation of Aldehydes: Green Synthesis of Carboxylic Acids and Esters by Sancineto, Luca, Tidei, Caterina, Bagnoli, Luana, Marini, Francesca, Lenardão, Eder J, Santi, Claudio

“…The stoichiometric use of hydrogen peroxide in the presence of a selenium-containing catalyst in water is here reported as a new ecofriendly protocol for the…”
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FDA-Approved Small Molecules in 2022: Clinical Uses and Their Synthesis by Benedetto Tiz, Davide, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Santi, Claudio, Sancineto, Luca

“…This review describes the recently FDA-approved drugs (in the year 2022). Many of these products contain active moieties that FDA had not previously approved,…”
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Organic Diselenides: Versatile Reagents, Precursors, and Intriguing Biologically Active Compounds by Claudio Santi, Cristina Tomassini, Luca Sancineto

“…In this account, we describe how some organic diselenides were successfully used in the past as reagents for asymmetric stereoselective synthesis and more…”
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Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors by Krasowska, Dorota, Iraci, Nunzio, Santi, Claudio, Drabowicz, Józef, Cieslak, Marcin, Kaźmierczak-Barańska, Julia, Palomba, Martina, Królewska-Golińska, Karolina, Magiera, Jakub, Sancineto, Luca

“…A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the…”
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Top Selling (2026) Small Molecule Orphan Drugs: A Journey into Their Chemistry by Benedetto Tiz, Davide, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Sancineto, Luca, Santi, Claudio

“…This review describes, from a chemical point of view, the top "blockbuster" small molecule orphan drugs according to their forecasted sales in 2026. Orphan…”
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