Search Results - "Santhanakrishnan, Sridhar"

Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome by Moreira, Wilfried, Santhanakrishnan, Sridhar, Dymock, Brian W, Dick, Thomas

“…Mycobacteria harbor two main degradative proteolytic machineries, the caseinolytic protease ClpP1P2 and a proteasome. We recently showed that Bortezomib…”
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Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Gharbi-Ayachi, Aicha, Santhanakrishnan, Sridhar, Wong, Yee Hwa, Chan, Kitti W K, Tan, Siok Thing, Bates, Roderick W, Vasudevan, Subhash G, El Sahili, Abbas, Lescar, Julien

“…Zika virus (ZIKV) remains a potentially significant public health concern because it can cause teratogenic effects, such as microcephaly in newborns and…”
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One-Pot UV-Triggered o‑Nitrobenzyl Dopamine Polymerization and Coating for Surface Antibacterial Application by Shi, Liya, Santhanakrishnan, Sridhar, Cheah, Yong Shung, Li, Min, Chai, Christina Li Lin, Neoh, Koon Gee

“…Dopamine (DA) protected by an o-nitrobenzyl functionality on its phenolic group was synthesized as a photolabile catecholamine derivative. This compound,…”
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The chemical reactivities of DOPA and dopamine derivatives and their regioselectivities upon oxidative nucleophilic trapping by Cheah, Yong Shung, Santhanakrishnan, Sridhar, Sullivan, Michael B., Neoh, Koon Gee, Chai, Christina L.L.

“…The chemical reactivities of four catecholamines, N-acetyl dopamine (NADA) and its dehydro derivative (NAΔDA), N-acetyl 3,4-dihydroxy-phenylalanine methyl…”
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Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome by Moreira, Wilfried, Santhanakrishnan, Sridhar, Ngan, Grace J Y, Low, Choon Bing, Sangthongpitag, Kanda, Poulsen, Anders, Dymock, Brian W, Dick, Thomas

“…is responsible for the greatest number of deaths worldwide due to a bacterial agent. We recently identified bortezomib (Velcade; compound 1) as a promising…”
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Methoxy group substitution on catechol ring of dopamine facilitates its polymerization and formation of surface coatings by Zhang, Jieyu, Cheah, Yong Shung, Santhanakrishnan, Sridhar, Neoh, Koon Gee, Chai, Christina L.L.

“…Deposition of polydopamine on substrates is a facile and effective method of surface modification and the deposited polydopamine can reduce silver ions to form…”
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Synthesis of Neplanocin A and Its 3′-Epimer via an Intramolecular Baylis–Hillman Reaction by Tan, Yun Xuan, Santhanakrishnan, Sridhar, Yang, Hai Yan, Chai, Christina L. L, Tam, Eric Kwok Wai

“…The key cyclopentenyl intermediate 11b was synthesized in 4 steps from d-ribose in 41% overall yield via an efficient intramolecular Baylis–Hillman reaction…”
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3-Deazaneplanocin A and Neplanocin A Analogues and Their Effects on Apoptotic Cell Death by Tam, Eric K. W., Nguyen, Tuan Minh, Lim, Cheryl Z. H., Lee, Puay Leng, Li, Zhimei, Jiang, Xia, Santhanakrishnan, Sridhar, Tan, Tiong Wei, Goh, Yi Ling, Wong, Sze Yue, Yang, Haiyan, Ong, Esther H. Q., Hill, Jeffrey, Yu, Qiang, Chai, Christina L. L.

“…3‐Deazaneplanocin A (DzNep) is a potential epigenetic drug for the treatment of various cancers. DzNep has been reported to deplete histone methylations,…”
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Cell-Based Proteome Profiling Using an Affinity-Based Probe (AfBP) Derived from 3-Deazaneplanocin A () by Tam, Eric K. W., Li, Zhengqiu, Goh, Yi Ling, Cheng, Xiamin, Wong, Sze Yue, Santhanakrishnan, Sridhar, Chai, Christina L. L., Yao, Shao Q.

“…3‐Deazaneplanocin A (DzNep), a global histone methylation inhibitor, has attracted significant interest in epigenetic research in recent years. The molecular…”
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3-DeazaneplanocinA and NeplanocinA Analogues and Their Effects on Apoptotic Cell Death by Tam, Eric K W, Nguyen, Tuan Minh, Lim, Cheryl Z H, Lee, Puay Leng, Li, Zhimei, Jiang, Xia, Santhanakrishnan, Sridhar, Tan, Tiong Wei, Goh, Yi Ling, Wong, Sze Yue, Yang, Haiyan, Ong, Esther H Q, Hill, Jeffrey, Yu, Qiang, Chai, Christina L L

“…3-DeazaneplanocinA (DzNep) is a potential epigenetic drug for the treatment of various cancers. DzNep has been reported to deplete histone methylations,…”
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