Search Results - "Santer, R"

Androgen receptor signaling in prostate cancer by Culig, Zoran, Santer, Frédéric R.

“…The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary prostate cancer and in metastases. AR regulates multiple cellular…”
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MYC-Mediated Ribosomal Gene Expression Sensitizes Enzalutamide-resistant Prostate Cancer Cells to EP300/CREBBP Inhibitors by Furlan, Tobias, Kirchmair, Alexander, Sampson, Natalie, Puhr, Martin, Gruber, Martina, Trajanoski, Zlatko, Santer, Frédéric R., Parson, Walther, Handle, Florian, Culig, Zoran

“…Patients with advanced prostate cancer are frequently treated with the antiandrogen enzalutamide. However, resistance eventually develops in virtually all…”
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Therapy escape mechanisms in the malignant prostate by Santer, Frédéric R, Erb, Holger H.H, McNeill, Rhiannon V

“…Abstract Androgen receptor (AR) is the main target for prostate cancer therapy. Clinical approaches for AR inactivation include chemical castration, inhibition…”
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Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient‐derived xenograft (PDX) models by Navone, Nora M., van Weerden, Wytske M., Vessella, Robert L., Williams, Elizabeth D., Wang, Yuzhuo, Isaacs, John T., Nguyen, Holly M., Culig, Zoran, van der Pluijm, Gabri, Rentsch, Cyril A., Marques, Rute B., de Ridder, Corrina M. A., Bubendorf, Lukas, Thalmann, George N., Brennen, William Nathaniel, Santer, Frédéric R., Moser, Patrizia L., Shepherd, Peter, Efstathiou, Eleni, Xue, Hui, Lin, Dong, Buijs, Jeroen, Bosse, Tjalling, Collins, Anne, Maitland, Norman, Buzza, Mark, Kouspou, Michelle, Achtman, Ariel, Taylor, Renea A., Risbridger, Gail, Corey, Eva

“…Background While it has been challenging to establish prostate cancer patient‐derived xenografts (PDXs), with a take rate of 10‐40% and long latency time,…”
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Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines by Santer, Frédéric R, Höschele, Philipp P S, Oh, Su Jung, Erb, Holger H H, Bouchal, Jan, Cavarretta, Ilaria T, Parson, Walther, Meyers, David J, Cole, Philip A, Culig, Zoran

“…Inhibitors of histone deacetylases have been approved for clinical application in cancer treatment. On the other hand, histone acetyltransferase (HAT)…”
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Isochromosome 12p Formation Regulates Vitamin D Metabolism in Testicular Cancer by Törzsök, Peter, Van Goubergen, Jasper, Pichler, Martin, Pichler, Renate, Santer, Frédéric R

“…Isochromosome 12p (iChr12p) is typical in almost all invasive testicular cancers. Increased copy number of genes on 12p is associated with the development of a…”
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Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways by PUHR, Martin, SANTER, Frédéric R, NEUWIRT, Hannes, SUSANI, Martin, NEMETH, Jeffrey A, HOBISCH, Alfred, KENNER, Lukas, CULIG, Zoran

“…Suppressor of cytokine signaling-3 (SOCS-3) acts as a negative feedback regulator of the Janus-activated kinase/signal transducers and activators of…”
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The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models by Handle, Florian, Puhr, Martin, Schaefer, Georg, Lorito, Nicla, Hoefer, Julia, Gruber, Martina, Guggenberger, Fabian, Santer, Frédéric R, Marques, Rute B, van Weerden, Wytske M, Claessens, Frank, Erb, Holger H H, Culig, Zoran

“…IL6/STAT3 signaling is associated with endocrine therapy resistance in prostate cancer, but therapies targeting this pathway in prostate cancer were…”
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Oncolytic activity of the rhabdovirus VSV‐GP against prostate cancer by Urbiola, Carles, Santer, Frédéric R., Petersson, Monika, van der Pluijm, Gabri, Horninger, Wolfgang, Erlmann, Patrik, Wollmann, Guido, Kimpel, Janine, Culig, Zoran, von Laer, Dorothee

“…Oncolytic viruses, including the oncolytic rhabdovirus VSV‐GP tested here, selectively infect and kill cancer cells and are a promising new therapeutic…”
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Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells by Santer, Frédéric R, Malinowska, Kamilla, Culig, Zoran, Cavarretta, Ilaria T

“…Interleukin-6 (IL-6) is suggested to have a pathogenic role in the progression of prostate cancer (PC), therefore representing an attractive target for new…”
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p300 is upregulated by docetaxel and is a target in chemoresistant prostate cancer by Gruber, Martina, Ferrone, Lavinia, Puhr, Martin, Santer, Frédéric R, Furlan, Tobias, Eder, Iris E, Sampson, Natalie, Schäfer, Georg, Handle, Florian, Culig, Zoran

“…Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic castration-resistant prostate cancer (mCRPC) and results in…”
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Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways by Oh, Su Jung, Erb, Holger H H, Hobisch, Alfred, Santer, Frédéric R, Culig, Zoran

“…Antihormonal and chemotherapy are standard treatments for nonorgan-confined prostate cancer. The effectivity of these therapies is limited and the development…”
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SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells by Handle, Florian, Erb, Holger H H, Luef, Birgit, Hoefer, Julia, Dietrich, Dimo, Parson, Walther, Kristiansen, Glen, Santer, Frédéric R, Culig, Zoran

“…The proinflammatory cytokine IL6 is associated with bad prognosis in prostate cancer and implicated in progression to castration resistance. Suppressor of…”
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Retrieving of particulate matter from optical measurements: A semiparametric approach by Pelletier, B., Santer, R., Vidot, J.

“…The fine particle abundance, i.e., particle matter (PM) concentration, is one of the indicators of air quality and is therefore subject to ground‐based…”
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Olaparib is effective in combination with, and as maintenance therapy after, first‐line endocrine therapy in prostate cancer cells by Feiersinger, Gertrud E., Trattnig, Kristina, Leitner, Peter D., Guggenberger, Fabian, Oberhuber, Alexander, Peer, Sarah, Hermann, Martin, Skvortsova, Ira, Vrbkova, Jana, Bouchal, Jan, Culig, Zoran, Santer, Frédéric R.

“…A number of prostate cancer (PCa)‐specific genomic aberrations (denominated BRCAness genes) have been discovered implicating sensitivity to PARP inhibition…”
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The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1 by Luef, Birgit, Handle, Florian, Kharaishvili, Gvantsa, Hager, Martina, Rainer, Johannes, Janetschek, Günter, Hruby, Stephan, Englberger, Christine, Bouchal, Jan, Santer, Frédéric R, Culig, Zoran

“…Due to the urgent need for new prostate cancer (PCa) therapies, the role of androgen receptor (AR)-interacting proteins should be investigated. In this study…”
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Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases by Neuwirt, Hannes, Puhr, Martin, Santer, Frédéric R, Susani, Martin, Doppler, Wolfgang, Marcias, Gemma, Rauch, Veronika, Brugger, Maria, Hobisch, Alfred, Kenner, Lukas, Culig, Zoran

“…Suppressor of cytokine signaling (SOCS) proteins play a pivotal role in the development and progression of various cancers. We have previously shown that…”
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Molecular aspects of androgenic signaling and possible targets for therapeutic intervention in prostate cancer by Culig, Zoran, Santer, Frédéric R.

“…•Androgen receptor is expressed in castration-resistant tumors.•Intracrine androgen synthesis occurs in prostate tumorigenesis.•Several coactivators enhance…”
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Treatment recommendations in long-chain fatty acid oxidation defects: consensus from a workshop by Spiekerkoetter, U, Lindner, M, Santer, R, Grotzke, M, Baumgartner, M. R, Boehles, H, Das, A, Haase, C, Hennermann, J. B, Karall, D, de Klerk, H, Knerr, I, Koch, H. G, Plecko, B, Röschinger, W, Schwab, K. O, Scheible, D, Wijburg, F. A, Zschocke, J, Mayatepek, E, Wendel, U

“…Published data on treatment of fatty acid oxidation defects are scarce. Treatment recommendations have been developed on the basis of observations in 75…”
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Androgen receptor co-activators in the regulation of cellular events in prostate cancer by Culig, Zoran, Santer, Frédéric R.

“…Objectives Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more…”
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