Search Results - "Santen, R.J."

Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis by Yue, W, Santen, R.J, Wang, J.-P, Li, Y, Verderame, M.F, Bocchinfuso, W.P, Korach, K.S, Devanesan, P, Todorovic, R, Rogan, E.G, Cavalieri, E.L

“…Long term exposure to estradiol increases the risk of breast cancer in a variety of animal species, as well as in women. The mechanisms responsible for this…”
Get full text

Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report by Sasano, H, Edwards, D.P, Anderson, T.J, Silverberg, S.G, Evans, D.B, Santen, R.J, Ramage, P, Simpson, E.R, Bhatnagar, A.S, Miller, W.R

“…Intratumoral aromatase is a potential therapeutic target for the treatment of postmenopausal estrogen-dependent breast cancers. Therefore, reliable methods…”
Get full text

5195 HMPS (2-hydroxy-4-methoxyphenylstilbene), a stilbene derivative of rhapontigenin, induces cell death by mitochondrial apoptotic pathway in breast cancer cells by Jung, J.H, Kim, J.Y, Park, H.Y, Chae, Y.S, Jung, H.J, Aiyar, S.E, Santen, R.J, Kim, S.H

Get full text

Estrogen production via the aromatase enzyme in breast carcinoma: which cell type is responsible? by Santen, R.J., Santner, S.J., Pauley, R.J., Tait, L., Kaseta, J., Demers, L.M., Hamilton, C., Yue, W., Wang, J.-P.

“…Studies of breast tumor homogenates from women with breast cancer have demonstrated the synthesis of estrogens in situ through the enzyme aromatase. The…”
Get full text

Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture by Santner, S J, Chen, S, Zhou, D, Korsunsky, Z, Martel, J, Santen, R J

“…Aromatase is present in human breast tumors and in breast cancer cell lines suggesting the possibility of in-situ estrogen production via the androstenedione…”
Get more information

The validation of new aromatase monoclonal antibodies for immunohistochemistry—A correlation with biochemical activities in 46 cases of breast cancer by Sasano, H., Anderson, T.J., Silverberg, S.G., Santen, R.J., Conway, M., Edwards, D.P., Krause, A., Bhatnagar, A.S., Evans, D.B., Miller, W.R.

“…Intratumoral aromatase is a therapeutic target for the treatment of post-menopausal estrogen-dependent breast cancers. Therefore, reliable methods should be…”
Get full text

Adaptive mechanisms induced by long-term estrogen deprivation in breast cancer cells by Song, R.X, Santen, R.J, Kumar, R, Adam, L, Jeng, M.-H, Masamura, S, Yue, W

“…Clinical observations suggest that human breast tumors can adapt in response to endocrine therapy by developing hypersensitivity to estradiol. To understand…”
Get full text

Adaptive hypersensitivity to estrogen: Mechanisms and clinical relevance to aromatase inhibitor therapy in breast cancer treatment by Santen, R.J., Song, R.X., Zhang, Z., Kumar, R., Jeng, M.-H., Masamura, S., Lawrence, J., MacMahon, L.P., Yue, W., Berstein, L.

“…Breast tumors in women can adapt to endocrine deprivation therapy by developing hypersensitivity to estradiol. For this reason, aromatase inhibitors can be…”
Get full text

Effect of CGS 20267 on ovarian aromatase and gonadotropin levels in the rat by SINHA, S, KASETA, J, SANTNER, S. J, DEMERS, L. M, BREMMER, W. J, SANTEN, R. J

“…Aromatase catalyzes the rate limiting step that converts androgens to estrogens. Postmenopausal women with hormone dependent breast cancer respond to first…”
Get full text

Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts by SANTEN, R. J, MARTEL, J, HOAGLAND, M, NAFTOLIN, F, ROA, L, HARADA, N, HAFER, L, ZAINO, R, PAULEY, R, SANTNER, S

“…Breast tumors from post-menopausal women contain higher amounts of estradiol than would be predicted from levels circulating in plasma. This observation raised…”
Get full text

Three-component model of oestrogen formation and regulation of intratumoural oestrogen pool in breast neoplasms by Berstein, L.M., Santen, R.J., Santner, S.J.

“…Although a two-component model system (i.e. epithelial and stromal spindle-shaped cells) may explain the regulation of aromatase activity and the location of…”
Get full text

Androgen-primed chemotherapy-experimental confirmation of efficacy by Santen, R J, Manni, A, English, H F, Heitjan, D

“…A current hypothesis suggests that androgen administration prior to chemotherapy (androgen priming) may potentiate tumor cytotoxicity in prostate cancer. The…”
Get more information

Aminoglutethimide as an aromatase inhibitor in the treatment of cancer by Santen, R J

Get more information

Clinical and biochemical effect of aminoglutethimide in the treatment of advanced prostatic carcinoma by Worgul, T J, Santen, R J, Samojlik, E, Veldhuis, J D, Lipton, A, Harvey, H A, Drago, J R, Rohner, T J

“…Treatment of male patients with advanced prostatic carcinoma and disease progression after initial endocrine therapy frequently is unsatisfactory. However,…”
Get more information

Gonadotropin-releasing hormone: physiological and therapeutic aspects, agonists and antagonists by Santen, R J, Bourguignon, J P

“…Rapid advances in the understanding of gonadotropin-releasing hormone (GnRH) actions and in development of new agonist and antagonist analogues of GnRH have…”
Get more information

The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma by Sanford, E J, Paulson, D F, Rohner, Jr, T J, Santen, R J, Bardin, C W

“…Selective adrenal vein catheterization was done on intact and castrated men with prostatic carcinoma. Adrenal to peripheral venous testosterone gradients were…”
Get more information

Integration of pulsatile gonadotropin secretion by timed urinary measurements: an accurate and sensitive 3-hour test by Kulin, H E, Bell, P M, Santen, R J, Ferber, A J

“…The integration of pulsatile gonadotropin secretion by the radioimmunoassay of an acetone precipitation from a short-term urine sample was evaluated. FSH and…”
Get more information

Automated estimation of diploid and tetraploid nuclei with an electronic particle counter by Santen, R J

Get more information

Mechanism of suppression of gonadotropin levels in a patient with a prolactin-secreting adenoma: a longitudinal case study by Rolland, R, Santen, R J, Herman, S P, Northrup, B

Get more information

Rhythms in the secretion of gonadotropins and gonadal steroids by Baker, H W, Santen, R J, Burger, H G, De Kretser, D M, Hudson, B, Pepperell, R J, Bardin, C W

Get more information