Search Results - "Santel, Ansgar"

Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1 by Santel, Ansgar, Frank, Stephan

“…Mitochondria are essential and dynamic cellular organelles differing in size, subcellular distribution, and internal structure. These aspects of mitochondrial…”
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Get the balance right: Mitofusins roles in health and disease by Santel, Ansgar

“…Mitochondria are highly dynamic organelles exhibiting an elaborate morphology and fine structure. Fusion and fission processes contribute to the maintenance…”
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Control of mitochondrial morphology by a human mitofusin by Santel, A, Fuller, M T

“…Although changes in mitochondrial size and arrangement accompany both cellular differentiation and human disease, the mechanisms that mediate mitochondrial…”
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Gene control of tyrosine kinase TIE2 and vascular manifestations of infections by Ghosh, Chandra C., David, Sascha, Zhang, Ruyang, Berghelli, Anthony, Milam, Katelyn, Higgins, Sarah J., Hunter, Jon, Mukherjee, Aditi, Wei, Yongyue, Tran, Mei, Suber, Freeman, Kobzik, Lester, Kain, Kevin C., Lu, Shulin, Santel, Ansgar, Yano, Kiichiro, Guha, Prajna, Dumont, Daniel J., Christiani, David C., Parikh, Samir M.

“…Ligands of the endothelial-enriched tunica interna endothelial cell kinase 2 (Tie2) are markedly imbalanced in severe infections associated with vascular…”
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Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression by Aleku, Manuela, Schulz, Petra, Keil, Oliver, Santel, Ansgar, Schaeper, Ute, Dieckhoff, Britta, Janke, Oliver, Endruschat, Jens, Durieux, Birgit, Röder, Nadine, Löffler, Kathrin, Lange, Christian, Fechtner, Melanie, Möpert, Kristin, Fisch, Gerald, Dames, Sibylle, Arnold, Wolfgang, Jochims, Karin, Giese, Klaus, Wiedenmann, Bertram, Scholz, Arne, Kaufmann, Jörg

“…We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the vasculature of mice. Here we report…”
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Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models by SANTEL, Ansgar, ALEKU, Manuela, EISERMANN, Mona, LÖFFLER, Kathrin, FECHTNER, Melanie, FISCH, Gerald, VANK, Christiane, SCHAEPER, Ute, GIESE, Klaus, KAUFMANN, Jörg, RÖDER, Nadine, MÖPERT, Kristin, DURIEUX, Birgit, JANKE, Oliver, KEIL, Oliver, ENDRUSCHAT, Jens, DAMES, Sibylle, LANGE, Christian

“…Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. The aim of this study…”
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Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage by Radloff, Katrin, Gutbier, Birgitt, Dunne, Charlotte Maeve, Moradian, Hanieh, Schwestka, Marko, Gossen, Manfred, Ahrens, Katharina, Kneller, Laura, Wang, Yadong, Moga, Akanksha, Gkionis, Leonidas, Keil, Oliver, Fehring, Volker, Tondera, Daniel, Giese, Klaus, Santel, Ansgar, Kaufmann, Jörg, Witzenrath, Martin

“…Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically…”
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Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization by Möpert, Kristin, Hajek, Petr, Frank, Stephan, Chen, Christiane, Kaufmann, Jörg, Santel, Ansgar

“…RNAi mediated loss of Drp1 function changes mitochondrial morphology in cultured HeLa and HUVEC cells by shifting the balance of mitochondrial fission and…”
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Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells by Santel, Ansgar, Frank, Stephan, Gaume, Brigitte, Herrler, Michael, Youle, Richard J, Fuller, Margaret T

“…Mitochondrial fusion may regulate mitochondrial morphogenesis and underlie complementation between mitochondrial genomes in mammalian cells. The nuclear…”
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mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells by Tondera, Daniel, Czauderna, Frank, Paulick, Katharina, Schwarzer, Rolf, Kaufmann, Jörg, Santel, Ansgar

“…Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein…”
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Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation by Möpert, Kristin, Löffler, Kathrin, Röder, Nadine, Kaufmann, Jörg, Santel, Ansgar

“…Several pathways are involved in the control of endothelial cell morphology, endothelial permeability and function in order to maintain vascular homeostasis…”
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Knockdown of MTP18, a Novel Phosphatidylinositol 3-Kinase-dependent Protein, Affects Mitochondrial Morphology and Induces Apoptosis by Tondera, Daniel, Santel, Ansgar, Schwarzer, Rolf, Dames, Sybille, Giese, Klaus, Klippel, Anke, Kaufmann, Jörg

“…We identified a novel human cDNA encoding a mitochondrial protein, MTP18 (mitochondrial protein, 18 kDa) as a transcriptional downstream target of…”
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RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice by Gutbier, Birgitt, Kube, Stefanie M, Reppe, Katrin, Santel, Ansgar, Lange, Christian, Kaufmann, Jörg, Suttorp, Norbert, Witzenrath, Martin

“…Abstract The ability of synthetic small interfering RNA (siRNA) to silence gene expression makes it a useful tool in biomedical research. However, effective…”
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Isoform-specific Interaction of C-RAF with Mitochondria by Galmiche, Antoine, Fueller, Jochen, Santel, Ansgar, Krohne, Georg, Wittig, Ilka, Doye, Anne, Rolando, Monica, Flatau, Gilles, Lemichez, Emmanuel, Rapp, Ulf R.

“…The proteins of the RAF family (A-RAF, B-RAF, and C-RAF) are serine/threonine kinases that play important roles in development, mature cell regulation, and…”
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Intracellular localization of lipoplexed siRNA in vascular endothelial cells of different mouse tissues by Aleku, Manuela, Fisch, Gerald, Möpert, Kristin, Keil, Oliver, Arnold, Wolfgang, Kaufmann, Jörg, Santel, Ansgar

“…Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene…”
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Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis by Ghosh, Chandra C., Thamm, Kristina, Berghelli, Anthony V., Schrimpf, Claudia, Maski, Manish R., Abid, Tanaz, Milam, Katelyn E., Rajakumar, Augustine, Santel, Ansgar, Kielstein, Jan T., Ahmed, Asif, Thickett, David, Wang, Keqin, Chase, Maureen, Donnino, Michael W., Aird, William C., Haller, Hermann, David, Sascha, Parikh, Samir M.

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First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors by Schultheis, Beate, Strumberg, Dirk, Santel, Ansgar, Vank, Christiane, Gebhardt, Frank, Keil, Oliver, Lange, Christian, Giese, Klaus, Kaufmann, Jörg, Khan, Michael, Drevs, Joachim

“…Atu027 is a novel liposomal RNA interference therapeutic that includes a short-interfering RNA (siRNA), which silences expression of protein kinase N3 in the…”
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Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa by Santel, A, Blumer, N, Kampfer, M, Renkawitz-Pohl, R

“…The Drosophila don juan gene encodes a basic protein (Don Juan protein), which is solely expressed postmeiotically during spermiogenesis in elongated…”
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Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia by Gutbier, Birgitt, Neuhauß, Anne-Kathrin, Reppe, Katrin, Ehrler, Carolin, Santel, Ansgar, Kaufmann, Jörg, Scholz, Markus, Weissmann, Norbert, Morawietz, Lars, Mitchell, Timothy J, Aliberti, Stefano, Hippenstiel, Stefan, Suttorp, Norbert, Witzenrath, Martin

“…During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2 activation by angiopoietin-1 reduces, whereas Tie2 blockade…”
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The Role of Akt in Chronic Liver Disease and Liver Regeneration by Morales-Ruiz, Manuel, Santel, Ansgar, Ribera, Jordi, Jiménez, Wladimiro

“…The liver is continuously exposed to diverse insults, which may culminate in pathological processes causing liver disease. An effective therapeutic strategy…”
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