Search Results - "Santander, Nicolas"

A new genetic strategy for targeting microglia in development and disease by McKinsey, Gabriel L, Lizama, Carlos O, Keown-Lang, Amber E, Niu, Abraham, Santander, Nicolas, Larpthaveesarp, Amara, Chee, Elin, Gonzalez, Fernando F, Arnold, Thomas D

“…As the resident macrophages of the brain and spinal cord, microglia are crucial for the phagocytosis of infectious agents, apoptotic cells and synapses. During…”
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APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints by Yin, Zhuoran, Rosenzweig, Neta, Kleemann, Kilian L., Zhang, Xiaoming, Brandão, Wesley, Margeta, Milica A., Schroeder, Caitlin, Sivanathan, Kisha N., Silveira, Sebastian, Gauthier, Christian, Mallah, Dania, Pitts, Kristen M., Durao, Ana, Herron, Shawn, Shorey, Hannah, Cheng, Yiran, Barry, Jen-Li, Krishnan, Rajesh K., Wakelin, Sam, Rhee, Jared, Yung, Anthony, Aronchik, Michael, Wang, Chao, Jain, Nimansha, Bao, Xin, Gerrits, Emma, Brouwer, Nieske, Deik, Amy, Tenen, Daniel G., Ikezu, Tsuneya, Santander, Nicolas G., McKinsey, Gabriel L., Baufeld, Caroline, Sheppard, Dean, Krasemann, Susanne, Nowarski, Roni, Eggen, Bart J. L., Clish, Clary, Tanzi, Rudolph E., Madore, Charlotte, Arnold, Thomas D., Holtzman, David M., Butovsky, Oleg

“…The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD pathogenesis is…”
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A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models by Bedolla, Alicia M., McKinsey, Gabriel L., Ware, Kierra, Santander, Nicolas, Arnold, Thomas D., Luo, Yu

“…The recent proliferation of new Cre and CreER recombinase lines provides researchers with a diverse toolkit to study microglial gene function. To determine how…”
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Transcriptional and Epigenomic Markers of the Arterial-Venous and Micro/Macro-Vascular Endothelial Heterogeneity within the Umbilical-Placental Bed by Arenas, German A., Santander, Nicolas, Krause, Bernardo J.

“…Umbilical and placental vessels and endothelial cells (EC) are common models to study placental function and vascular programming. Arterio-venous differences…”
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A Quinoa Protein Hydrolysate Fractionated by Electrodialysis with Ultrafiltration Membranes Improves Maternal and Fetal Outcomes in a Mouse Model of Gestational Diabetes Mellitus by Busso, Dolores, González, Adrián, Santander, Nicolás, Saavedra, Fujiko, Quiroz, Alonso, Rivera, Katherine, González, Javier, Olmos, Pablo, Marette, André, Bazinet, Laurent, Illanes, Sebastián, Enrione, Javier

“…Scope Quinoa intake exerts hypoglycemic and hypolipidemic effects in animals and humans. Although peptides from quinoa inhibit key enzymes involved in glucose…”
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High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation by Contreras-Duarte, Susana, Santander, Nicolás, Birner-Gruenberger, Ruth, Wadsack, Christian, Rigotti, Attilio, Busso, Dolores

“…Scavenger receptor class B type 1 (SR-B1) plays an essential role in high density lipoprotein (HDL) metabolism. SR-B1 deficient (SR-B1 KO) mice are prone to…”
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Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure by Santander, Nicolás, Lizama, Carlos, Murgas, Leandro, Contreras, Sebastián, Martin, Alberto J M, Molina, Paz, Quiroz, Alonso, Rivera, Katherine, Salas-Pérez, Francisca, Godoy, Alejandro, Rigotti, Attilio, Busso, Dolores

“…The high-density lipoprotein receptor SR-B1 mediates cellular uptake of several lipid species, including cholesterol and vitamin E. During early mouse…”
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Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis by Santander, Nicolas, Arnold, Thomas D

“…Endothelial cells in the brain interact with other cell types, forming the blood-brain barrier. This barrier controls the movement of solutes into and out of…”
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Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI by Santander, Nicolás Guillermo, Contreras-Duarte, Susana, Awad, María Fernanda, Lizama, Carlos, Passalacqua, Isabella, Rigotti, Attilio, Busso, Dolores

“…The srbi gene encodes a lipoprotein receptor with high affinity for high density lipoprotein that is mainly expressed in the liver and in steroidogenic…”
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Insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo‐2 cells by upregulating SR‐BI via a PI3K, AKT, and mTOR‐dependent pathway by Fuentes, Marcela, Santander, Nicolás, Cortés, Víctor

“…The actions of insulin on intestinal cholesterol absorption and lipoprotein secretion are not well understood. Herein, we determined the effects of insulin on…”
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Ovarian cholesterol efflux: ATP-binding cassette transporters and follicular fluid HDL regulate cholesterol content in mouse oocytes by Quiroz, Alonso, Molina, Paz, Santander, Nicolás, Gallardo, Daniel, Rigotti, Attilio, Busso, Dolores

“…High density lipoproteins (HDL) take up cholesterol from peripheral tissues via ABC transporters and deliver it to the liver via scavenger receptor class B…”
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Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility by Arias, Andreina, Quiroz, Alonso, Santander, Nicolás, Morselli, Eugenia, Busso, Dolores

“…Cholesterol is an essential component of animal cells. Different regulatory mechanisms converge to maintain adequate levels of this lipid because both its…”
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Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI by Santander, Nicolás, Lizama, Carlos, Parga, María José, Quiroz, Alonso, Pérez, Druso, Echeverría, Guadalupe, Ulloa, Lorena, Palma, Verónica, Rigotti, Attilio, Busso, Dolores

“…SR-BI is the main receptor for high density lipoproteins (HDL) and mediates the bidirectional transport of lipids, such as cholesterol and vitamin E, between…”
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Structural and molecular basis of choline uptake into the brain by FLVCR2 by Cater, Rosemary J., Mukherjee, Dibyanti, Gil-Iturbe, Eva, Erramilli, Satchal K., Chen, Ting, Koo, Katie, Santander, Nicolás, Reckers, Andrew, Kloss, Brian, Gawda, Tomasz, Choy, Brendon C., Zhang, Zhening, Katewa, Aditya, Larpthaveesarp, Amara, Huang, Eric J., Mooney, Scott W. J., Clarke, Oliver B., Yee, Sook Wah, Giacomini, Kathleen M., Kossiakoff, Anthony A., Quick, Matthias, Arnold, Thomas, Mancia, Filippo

“…Choline is an essential nutrient that the human body needs in vast quantities for cell membrane synthesis, epigenetic modification and neurotransmission. The…”
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Oxidative Stress in Polycystic Ovary Syndrome: Impact of Combined Oral Contraceptives by Santander, Nicolás, Figueroa, Esteban G, González-Candia, Alejandro, Maliqueo, Manuel, Echiburú, Bárbara, Crisosto, Nicolás, Salas-Pérez, Francisca

“…Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that is associated with heightened metabolic risks. While oxidative stress (OS) is known to…”
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Lipoprotein receptor SR-B1 deficiency enhances adipose tissue inflammation and reduces susceptibility to hepatic steatosis during diet-induced obesity in mice by Rivera, Katherine, Quiñones, Verónica, Amigo, Ludwig, Santander, Nicolás, Salas-Pérez, Francisca, Xavier, Aline, Fernández-Galilea, Marta, Carrasco, Gonzalo, Cabrera, Daniel, Arrese, Marco, Busso, Dolores, Andia, Marcelo E., Rigotti, Attilio

“…Scavenger receptor class B type 1 (SR-B1) is a membrane lipoprotein receptor/lipid transporter involved in the pathogenesis of atherosclerosis, but its role in…”
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Development of an Improved Method for Genetic Fate Mapping of Brain Microglia by McKinsey, Gabriel L., Chee, Elin, Santander, Nicolas, Arnold, Thomas D.

“…As the resident macrophage cells of the brain, microglia are crucial for the phagocytosis of infectious agents, apoptotic cells and synapses. Developmentally,…”
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Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis by Rigotti, Attilio, Valdés, Gloria, Quiroz, Alonso, Santander, Nicolás, Berkowitz, Loni, Salas, Francisca, Mascareño, Lilian, Busso, Dolores, Amigo, Ludwig

“…The susceptibility to develop atherosclerosis is increased by intrauterine growth restriction and prenatal exposure to maternal hypercholesterolemia. Here, we…”
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Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction by Arnold, Thomas D, Lizama, Carlos O, Cautivo, Kelly M, Santander, Nicolas, Lin, Lucia, Qiu, Haiyan, Huang, Eric J, Liu, Chang, Mukouyama, Yoh-Suke, Reichardt, Louis F, Zovein, Ann C, Sheppard, Dean

“…Microglia play a pivotal role in the coordination of brain development and have emerged as a critical determinant in the progression of neurodegenerative…”
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Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier by Santander, Nicolas, Lizama, Carlos O, Meky, Eman, McKinsey, Gabriel L, Jung, Bongnam, Sheppard, Dean, Betsholtz, Christer, Arnold, Thomas D

“…Fowler syndrome is a rare autosomal recessive brain vascular disorder caused by mutation in FLVCR2 in humans. The disease occurs during a critical period of…”
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