Crohn's disease in one mixed-race population in Brazil

To evaluate the classification and severity of Crohn's disease in different racial groups. Patients with Crohn's disease from the outpatient clinic of the University Hospital Prof. Edgard Santos were enrolled in the study. This hospital is a reference centre for inflammatory bowel disease....

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Published in:	World journal of gastroenterology : WJG Vol. 13; no. 33; pp. 4489 - 4492
Main Authors:	Santana, Genoile Oliveira, Lyra, Luiz Guilherme Costa, Santana, Tamara Celi Almeida, Dos Reis, Lidiane Bianca, Guedes, Jorge Carvalho, Toralles, Maria Betania, Lyra, André Castro
Format:	Journal Article
Language:	English
Published:	United States Department of Medicine, Federal University of Bahia, Brazil%Genetic Unit, Federal University of Bahia, Brazil 07-09-2007 Gastrohepatology Unit, Hospital San Rafael, Bahia,Brazil%Gastrohepatology Unit,Federal University of Bahia, Brazil Gastrohepatology Unit, Hospital San Rafael, Bahia,Brazil%Department of Medicine, Federal University of Bahia, Brazil%Gastrohepatology Unit,Federal University of Bahia, Brazil Department of Medicine, Federal University of Bahia, Brazil Gastrohepatology Unit,Federal University of Bahia, Brazil Baishideng Publishing Group Co., Limited
Subjects:	Adult Brazil - epidemiology Crohn Disease - diagnosis Crohn Disease - epidemiology Crohn Disease - ethnology Crohn Disease - therapy Female Follow-Up Studies Genetic Predisposition to Disease Humans Male Population Groups Rapid Communication Brazil Inflammatory bowel disease Brazil Racial group Crohn's disease Race
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Summary:	To evaluate the classification and severity of Crohn's disease in different racial groups. Patients with Crohn's disease from the outpatient clinic of the University Hospital Prof. Edgard Santos were enrolled in the study. This hospital is a reference centre for inflammatory bowel disease. Race was determined using self-identification. The Vienna's classification was applied for all subjects. The severity of Crohn's disease was determined according to the number of surgical procedures, hospital admissions in the last year and treatment with steroids and immunosuppressors. Statistical analysis was calculated using t test for means, chi2 or F for proportions. A P value < 0.05 was considered to be significant. Sixty-five patients were enrolled. Non-white patients were more frequently diagnosed with Crohn's disease in the age less than 40 years than white patients. The behaviour of disease was similar in both groups with a high frequency of the penetrating form. There was a tendency for non-white patients to have a greater frequency of hospital admissions in the last year compared to white subjects. Non-whites also had a higher rate of colonic and upper gastrointestinal involvement, and were also more frequently on treatment with immunossupressors than white patients although this difference was not statistically significant. Non-white patients with Crohn's disease had an earlier diagnosis and appeared to have had a more severe disease presentation than white patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Genoile Oliveira Santana, Avenida Santos Dumont, Km 05, Condomínio Parque Encontro das Águas, Lote G31, Lauro de Freitas- BA Zip Code: 42.700.000, Brazil. genoile@uol.com.br Author contributions: All authors contributed equally to the work. Telephone: +55-71-99572121 Fax: +55-71-32357048
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v13.i33.4489