Search Results - "Santa Jeremy Ono"

CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-α, TGFβ-1 and IL-6 by Fifadara, Nimita H., Aye, Cho Cho, Raghuwanshi, Sandeep K., Richardson, Ricardo M., Ono, Santa Jeremy

“…Chemokine receptors (CCRs) are important co-stimulatory molecules found on many blood cells and associated with various diseases. The expression and function…”
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Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade by Miyazaki, Dai, Nakamura, Takao, Ohbayashi, Masaharu, Kuo, Chuan Hui, Komatsu, Naoki, Yakura, Keiko, Tominaga, Takeshi, Inoue, Yoshitsugu, Higashi, Hidemitsu, Murata, Meguru, Takeda, Shuzo, Fukushima, Atsuki, Liu, Fu-Tong, Rothenberg, Marc E., Ono, Santa Jeremy

“…The immune response is regulated, in part, by effector cells whose activation requires multiple signals. For example, T cells require signals emanating from…”
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Allergic conjunctivitis: Update on pathophysiology and prospects for future treatment by Ono, Santa Jeremy, Abelson, Mark B.

“…Allergic conjunctivitis is in actuality a group of diseases affecting the ocular surface and is usually associated with type 1 hypersensitivity reactions. Two…”
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Autoimmunity in retinal degeneration: Autoimmune retinopathy and age-related macular degeneration by Morohoshi, Kei, Goodwin, Anne M, Ohbayashi, Masaharu, Ono, Santa Jeremy

“…Abstract Autoantibody production is associated with a variety of ocular disorders, including autoimmune retinopathy (AIR) and age-related macular degeneration…”
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The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis by Fukuda, Ken, Kuo, Chuan-Hui, Morohoshi, Kei, Liu, Fu-Tong, Ono, Santa Jeremy

“…Allergic conjunctivitis is characterised by early-phase clinical symptoms and late-phase inflammation in the conjunctiva. The role of different chemokine…”
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Regulatory Function of CpG-Activated B Cells in Late-Phase Experimental Allergic Conjunctivitis by Miyazaki, Dai, Kuo, Chuan Hui, Tominaga, Takeshi, Inoue, Yoshitsugu, Ono, Santa Jeremy

“…To determine how CpG, an immunostimulatory sequence, affects experimental allergic conjunctivitis and to determine the mechanisms of its action. Experimental…”
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Circulating anti‐retinal antibodies as immune markers in age‐related macular degeneration by Patel, Nishal, Ohbayashi, Masahara, Nugent, Alex K., Ramchand, Kanchan, Toda, Masako, Chau, Kai‐Yin, Bunce, Catey, Webster, Andrew, Bird, Alan C., Ono, Santa Jeremy, Chong, Victor

“…Summary Age‐related macular maculopathy (ARM) and age‐related macular degeneration (AMD) are the leading causes of blindness in the Western world. Despite the…”
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Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas by Arlotta, Paola, Tai, Albert K.-F., Manfioletti, Guidalberto, Clifford, Charles, Jay, Gilbert, Ono, Santa Jeremy

“…Chromosomal translocations in human lipomas frequently create fusion transcripts encoding high mobility group (HMG) I-C DNA-binding domains and C-terminal…”
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Genomics and proteomics of allergic disease by Toda, Masako, Ono, Santa Jeremy

“…Summary The world‐wide effort to identify susceptibility genes for allergic diseases is motivated by the conviction that the identification of disease genes…”
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Molecular Dissection of the Architectural Transcription Factor HMGA2 by Noro, Barbara, Licheri, Barbara, Sgarra, Riccardo, Rustighi, Alessandra, Tessari, Michela A, Chau, Kai-Yin, Ono, Santa Jeremy, Giancotti, Vincenzo, Manfioletti, Guidalberto

“…HMGA2 protein belongs to the High Mobility Group A (HMGA) family of architectural transcription factors. These proteins establish a network of protein−protein…”
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The Dendritic Cell in Allergic Conjunctivitis by Manzouri, Bita, MD, Flynn, Tom, MD, Ohbayashi, Masaharu, PhD, Ono, Santa Jeremy, PhD

“…Abstract The acquired immune response in health and disease is initiated when foreign antigens are processed and presented to T lymphocytes via…”
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A specific CCR3 chemokine receptor antagonist inhibits both early and late phase allergic inflammation in the conjunctiva by Nakamura, Takao, Ohbayashi, Masaharu, Toda, Masako, Hall, David A, Horgan, Carmel M, Ono, Santa Jeremy

“…Allergic inflammation manifests as one of a number of diseases, including asthma, dermatitis, food allergy, vernal keratoconjunctivitis, and systemic…”
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Functional Domains of the Cone-Rod Homeobox (CRX) Transcription Factor by Chau, Kai-Yin, Chen, Shiming, Zack, Donald J., Ono, Santa Jeremy

“…The paired-like homeodomain transcription factor CRX (cone-rod homeobox) is involved in regulating photoreceptor gene expression and rod outer segment…”
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Immunity in the eye: lessons in organ-specific responses by Ono, Santa Jeremy

“…Fifty‐five years have past since Sir Peter Medawar first demonstrated that the fate of allografts differs in the skin, brain, subcutaneous tissue, and anterior…”
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Detailed Criteria for the Assessment of Clinical Symptoms in a New Murine Model of Severe Allergic Conjunctivitis by Nakamura, Takao, Toda, Masako, Ohbayashi, Masaharu, Ono, Santa Jeremy

“…PURPOSEThe aims of this research were to(1) generate a rapid protocol for the sensitization of rodents to a defined allergen without footpad injections yet…”
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Identification and Characterization of a Critical CP2-binding Element in the Human Interleukin-4 Promoter by Casolaro, Vincenzo, Keane-Myers, Andrea M., Swendeman, Steven L., Steindler, Corinna, Zhong, Fengming, Sheffery, Michael, Georas, Steve N., Ono, Santa Jeremy

“…Expression of cytokine genes in T cells is thought to result from a complex network of antigen- and mitogen-activated transcriptional regulators. CP2, a factor…”
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IFN-γ gene expression is controlled by the architectural transcription factor HMGA1 by Chau, Kai-Yin, Keane-Myers, Andrea M., Fedele, Monica, Ikeda, Yasuhiro, Creusot, Remi J., Menozzi, Lisa, Cousins, David J., Manfioletti, Guidalberto, Feigenbaum, Lionel, Fusco, Alfredo, Ono, Santa Jeremy

“…We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome…”
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Genetics of allergic disease: evidence for organ-specific susceptibility genes by Nishimura, A, Campbell-Meltzer, R S, Chute, K, Orrell, J, Ono, S J

“…While previous studies have probed the genetics of asthma and serum IgE levels, there have been no studies on the genetics of allergic conjunctivitis. This…”
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Mapping of the Interaction Site of the Defective Transcription Factor in the Class II Major Histocompatibility Complex Mutant Cell Line Clone-13 to the Divergent X2-Box (∗) by Ono, Santa Jeremy, Song, Zhimin

“…We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP. Several criteria indicated…”
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Evidence That Formation of Vimentin·Mitogen-activated Protein Kinase (MAPK) Complex Mediates Mast Cell Activation following FcεRI/CC Chemokine Receptor 1 Cross-talk by Toda, Masako, Kuo, Chuan-Hui, Borman, Satty K., Richardson, Ricardo Micheler, Inoko, Akihito, Inagaki, Masaki, Collins, Andrea, Schneider, Klaus, Ono, Santa Jeremy

“…Accumulating evidence points to cross-talk between FcεRI and CC chemokine receptor (CCR)-mediated signaling pathways in mast cells. Here, we propose that…”
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