Search Results - "Sant, Melissa E"

Mercaptan and dicarboxylate inhibitors of hamster dihydroorotase by Christopherson, Richard I, Schmalzl, Karl J, Szabados, Eve, Goodridge, Richard J, Harsanyi, Michael C, Sant, Melissa E, Algar, Elizabeth M, Anderson, Janet E, Armstrong, Alison

“…In mammals, dihydroorotase is part of a trifunctional protein, dihydroorotate synthetase, which catalyzes the first three reactions of de novo pyrimidine…”
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Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells by SANT, M. E, LYONS, S. D, PHILLIPS, L, CHRISTOPHERSON, R. I

“…The pathway for de novo biosynthesis of purine nucleotides contains two one-carbon transfer reactions catalyzed by glycinamide ribotide (GAR) and…”
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Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia by LYONS, S. D, SANT, M. E, CHRISTOPHERSON, R. I

“…The glutamine antagonists, acivicin (NSC 163501), azaserine (NSC 742), and 6-diazo-5-oxo-L-norleucine (DON) (NSC 7365), are potent inhibitors of many…”
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Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia by SANT, M. E, LYONS, S. D, KEMP, A. J, MCCLURE, L. K, SZABADOS, E, CHRISTOPHERSON, R. I

“…Pyrazofurin (NSC 143095) as the monophosphate derivative is a potent inhibitor of orotidine 5'-monophosphate (OMP) decarboxylase of the pyrimidine pathway and…”
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Chromatographic analysis of purine precursors in mouse L1210 leukemia by Sant, M E, Poiner, A, Harsanyi, M C, Lyons, S D, Christopherson, R I

“…A number of antagonists of nucleotide metabolism with anti-cancer activity affect the de novo purine pathway. To determine the biochemical mechanisms of…”
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1H and 31P NMR and HPLC studies of mouse L1210 leukemia cell extracts: the effect of Au(I) and Cu(I) diphosphine complexes on the cell metabolism by Berners-Price, S J, Sant, M E, Christopherson, R I, Kuchel, P W

“…The effect of the antitumor complex [Au(dppe)2]Cl (where dppe is Ph2P(CH2)2PPh2) on the overall metabolism of cultured mouse L1210 leukemia cells was…”
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