Stent composition and immune response after long-term coronary angioplasty

Stent composition and immune response after long-term coronary angioplasty

There are limited data about the influence of stent composition on immune responses after percutaneous coronary intervention (PCI). The aim was to compare the effects of PCI with conventional cobalt-chromium bare metal stent (BMS) and drug-eluting stent (DES) implantation on the modulation of humora...

Full description

Saved in:
Bibliographic Details
Published in:Physiology international Vol. 110; no. 4; p. 371
Main Authors: Sant'Anna, Viviane A R, Barbosa, Adriano H P, Souza, Rodrigo A, Sousa, José M A, Monfardini, Frederico, Gidlund, Magnus, Fonseca, Henrique A R
Format: Journal Article
Language:English
Published: Hungary 18-12-2023
Subjects:
Angioplasty, Balloon, Coronary
Autoantibodies
Drug-Eluting Stents
Female
Humans
Immunity
Male
Metals
Middle Aged
Percutaneous Coronary Intervention
Pilot Projects
Risk Factors
Stents
Treatment Outcome
oxidised-LDL
immune response
inflammation
stents
apolipoprotein B100
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There are limited data about the influence of stent composition on immune responses after percutaneous coronary intervention (PCI). The aim was to compare the effects of PCI with conventional cobalt-chromium bare metal stent (BMS) and drug-eluting stent (DES) implantation on the modulation of humoral and cellular immune responses. A randomised, single-centre, open pilot study involving patients with stable coronary artery disease eligible for PCI was performed. Blood samples were collected from the peripheral artery (PA) and the coronary sinus (CS) at baseline and 40 weeks following PCI. IgM and IgG autoantibodies (Abs), anti-oxLDL and anti-ApoB-D, as well as cytokine levels were evaluated by enzyme-linked immunosorbent assay. A total of 30 patients of 60 years mean age were included, 68% of whom were men. At the nine-month follow-up, a modulation in the levels of cytokines and autoantibodies was observed in both stent type groups. However, no difference was observed in the modulation of these markers between stents. The stent type promotes modulations in cellular and humoral immune responses in the long-term, with differences in the magnitude of effects in specific immune responses.
ISSN:2498-602X
DOI:10.1556/2060.2023.00162