Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum.

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Bibliographic Details
Published in:Tetrahedron letters Vol. 51; no. 46; pp. 6031 - 6033
Main Authors: Sansone, Matthew F., Koyanagi, Takaoki, Przybyla, David E., Nagorski, Richard W.
Format: Journal Article
Language:English
Published: Elsevier Ltd 17-11-2010
Subjects:
Amides
Drying
Heating
High vacuum
Monoacylaminal
Precursors
Purification
Solvent-free
Synthesis (chemistry)
Tetrahedrons
Monoacylaminal
Solvent-free
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Description
Summary:A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum.
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.09.043