Search Results - "Sansom, Stephen N."

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages by Schulthess, Julie, Pandey, Sumeet, Capitani, Melania, Rue-Albrecht, Kevin C., Arnold, Isabelle, Franchini, Fanny, Chomka, Agnieszka, Ilott, Nicholas E., Johnston, Daniel G.W., Pires, Elisabete, McCullagh, James, Sansom, Stephen N., Arancibia-Cárcamo, Carolina V., Uhlig, Holm H., Powrie, Fiona

“…Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation of this response through microbial dysbiosis or defective…”
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Distinct fibroblast subsets drive inflammation and damage in arthritis by Croft, Adam P., Campos, Joana, Jansen, Kathrin, Turner, Jason D., Marshall, Jennifer, Attar, Moustafa, Savary, Loriane, Wehmeyer, Corinna, Naylor, Amy J., Kemble, Samuel, Begum, Jenefa, Dürholz, Kerstin, Perlman, Harris, Barone, Francesca, McGettrick, Helen M., Fearon, Douglas T., Wei, Kevin, Raychaudhuri, Soumya, Korsunsky, Ilya, Brenner, Michael B., Coles, Mark, Sansom, Stephen N., Filer, Andrew, Buckley, Christopher D.

“…The identification of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development of targeted therapies in immune-mediated…”
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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis by Alivernini, Stefano, MacDonald, Lucy, Elmesmari, Aziza, Finlay, Samuel, Tolusso, Barbara, Gigante, Maria Rita, Petricca, Luca, Di Mario, Clara, Bui, Laura, Perniola, Simone, Attar, Moustafa, Gessi, Marco, Fedele, Anna Laura, Chilaka, Sabarinadh, Somma, Domenico, Sansom, Stephen N., Filer, Andrew, McSharry, Charles, Millar, Neal L., Kirschner, Kristina, Nerviani, Alessandra, Lewis, Myles J., Pitzalis, Costantino, Clark, Andrew R., Ferraccioli, Gianfranco, Udalova, Irina, Buckley, Christopher D., Gremese, Elisa, McInnes, Iain B., Otto, Thomas D., Kurowska-Stolarska, Mariola

“…Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which…”
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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia by Sansom, Stephen N, Shikama-Dorn, Noriko, Zhanybekova, Saule, Nusspaumer, Gretel, Macaulay, Iain C, Deadman, Mary E, Heger, Andreas, Ponting, Chris P, Holländer, Georg A

“…Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to…”
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Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus by Downes, Damien J., Cross, Amy R., Hua, Peng, Roberts, Nigel, Schwessinger, Ron, Cutler, Antony J., Munis, Altar M., Brown, Jill, Mielczarek, Olga, de Andrea, Carlos E., Melero, Ignacio, Gill, Deborah R., Hyde, Stephen C., Knight, Julian C., Todd, John A., Sansom, Stephen N., Issa, Fadi, Davies, James O. J., Hughes, Jim R.

“…The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19) pandemic has caused millions of deaths worldwide. Genome-wide association…”
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Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness by Tuoc, Tran Cong, Boretius, Susann, Sansom, Stephen N., Pitulescu, Mara-Elena, Frahm, Jens, Livesey, Frederick J., Stoykova, Anastassia

“…Increased cortical size is essential to the enhanced intellectual capacity of primates during mammalian evolution. The mechanisms that control cortical size…”
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GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis by Regan-Komito, Daniel, Swann, James W., Demetriou, Philippos, Cohen, E. Suzanne, Horwood, Nicole J., Sansom, Stephen N., Griseri, Thibault

“…Dysregulated hematopoiesis occurs in several chronic inflammatory diseases, but it remains unclear how hematopoietic stem cells (HSCs) in the bone marrow (BM)…”
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response by Haenseler, Walther, Sansom, Stephen N., Buchrieser, Julian, Newey, Sarah E., Moore, Craig S., Nicholls, Francesca J., Chintawar, Satyan, Schnell, Christian, Antel, Jack P., Allen, Nicholas D., Cader, M. Zameel, Wade-Martins, Richard, James, William S., Cowley, Sally A.

“…Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and…”
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Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex by Pereira, João D., Sansom, Stephen N., Smith, James, Dobenecker, Marc-Werner, Tarakhovsky, Alexander, Livesey, Frederick J., Crabtree, Gerald R.

“…Multipotent progenitor cells of the cerebral cortex balance self-renewal and differentiation to produce complex neural lineages in a fixed temporal order in a…”
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IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors by Swann, James W, Koneva, Lada A, Regan-Komito, Daniel, Sansom, Stephen N, Powrie, Fiona, Griseri, Thibault

“…An important comorbidity of chronic inflammation is anemia, which may be related to dysregulated activity of hematopoietic stem and progenitor cells (HSPCs) in…”
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The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis by Sansom, Stephen N, Griffiths, Dean S, Faedo, Andrea, Kleinjan, Dirk-Jan, Ruan, Youlin, Smith, James, van Heyningen, Veronica, Rubenstein, John L, Livesey, Frederick J

“…Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the…”
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Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis by Seneviratne, Anusha N, Edsfeldt, Andreas, Cole, Jennifer E, Kassiteridi, Christina, Swart, Maarten, Park, Inhye, Green, Patricia, Khoyratty, Tariq, Saliba, David, Goddard, Michael E, Sansom, Stephen N, Goncalves, Isabel, Krams, Rob, Udalova, Irina A, Monaco, Claudia

“…BACKGROUND:Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake…”
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The long non-coding RNA Dali is an epigenetic regulator of neural differentiation by Chalei, Vladislava, Sansom, Stephen N, Kong, Lesheng, Lee, Sheena, Montiel, Juan F, Vance, Keith W, Ponting, Chris P

“…Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent protein coding genes. Less clear is whether intergenic lncRNAs commonly…”
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IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells by Mazet, Julie M., Mahale, Jagdish N., Tong, Orion, Watson, Robert A., Lechuga‐Vieco, Ana Victoria, Pirgova, Gabriela, Lau, Vivian W. C., Attar, Moustafa, Koneva, Lada A., Sansom, Stephen N., Fairfax, Benjamin P., Gérard, Audrey

“…IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to…”
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Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb by Mi, Da, Carr, Catherine B., Georgala, Petrina A., Huang, Yu-Ting, Manuel, Martine N., Jeanes, Emily, Niisato, Emi, Sansom, Stephen N., Livesey, Frederick J., Theil, Thomas, Hasenpusch-Theil, Kerstin, Simpson, T. Ian, Mason, John O., Price, David J.

“…The mechanisms by which early spatiotemporal expression patterns of transcription factors such as Pax6 regulate cortical progenitors in a region-specific…”
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Cellular census of human fibrosis defines functionally distinct stromal cell types and states by Layton, Thomas B., Williams, Lynn, McCann, Fiona, Zhang, Mingjun, Fritzsche, Marco, Colin-York, Huw, Cabrita, Marisa, Ng, Michael T. H., Feldmann, Marc, Sansom, Stephen N., Furniss, Dominic, Xie, Weilin, Nanchahal, Jagdeep

“…Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many…”
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Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis by Ryzhakov, Grigory, West, Nathaniel R., Franchini, Fanny, Clare, Simon, Ilott, Nicholas E., Sansom, Stephen N., Bullers, Samuel J., Pearson, Claire, Costain, Alice, Vaughan-Jackson, Alun, Goettel, Jeremy A., Ermann, Joerg, Horwitz, Bruce H., Buti, Ludovico, Lu, Xin, Mukhopadhyay, Subhankar, Snapper, Scott B., Powrie, Fiona

“…Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice,…”
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CGAT: computational genomics analysis toolkit by Sims, David, Ilott, Nicholas E., Sansom, Stephen N., Sudbery, Ian M., Johnson, Jethro S., Fawcett, Katherine A., Berlanga-Taylor, Antonio J., Luna-Valero, Sebastian, Ponting, Chris P., Heger, Andreas

“…Computational genomics seeks to draw biological inferences from genomic datasets, often by integrating and contextualizing next-generation sequencing data…”
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A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice by Jain, Reema, Sheridan, Julie M., Policheni, Antonia, Heinlein, Melanie, Gandolfo, Luke C., Dewson, Grant, Smyth, Gordon K., Sansom, Stephen N., Fu, Nai Yang, Visvader, Jane E., Holländer, Georg A., Strasser, Andreas, Gray, Daniel H.D.

“…T-cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. To…”
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Author Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states by Layton, Thomas B., Williams, Lynn, McCann, Fiona, Zhang, Mingjun, Fritzsche, Marco, Colin-York, Huw, Cabrita, Marisa, Ng, Michael T. H., Feldmann, Marc, Sansom, Stephen N., Furniss, Dominic, Xie, Weilin, Nanchahal, Jagdeep

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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