Search Results - "Sansom, P."

Water in Nanopores and Biological Channels: A Molecular Simulation Perspective by Lynch, Charlotte I, Rao, Shanlin, Sansom, Mark S. P

“…This Review explores the dynamic behavior of water within nanopores and biological channels in lipid bilayer membranes. We focus on molecular simulation…”
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Organization and Dynamics of Receptor Proteins in a Plasma Membrane by Koldsø, Heidi, Sansom, Mark S. P

“…The interactions of membrane proteins are influenced by their lipid environment, with key lipid species able to regulate membrane protein function. Advances in…”
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Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs by Kumar, Arvind, Basak, Sandip, Rao, Shanlin, Gicheru, Yvonne, Mayer, Megan L., Sansom, Mark S. P., Chakrapani, Sudha

“…Glycinergic synapses play a central role in motor control and pain processing in the central nervous system. Glycine receptors (GlyRs) are key players in…”
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Reduced lateral mobility of lipids and proteins in crowded membranes by Goose, Joseph E, Sansom, Mark S P

“…Coarse-grained molecular dynamics simulations of the E. coli outer membrane proteins FhuA, LamB, NanC, OmpA and OmpF in a POPE/POPG (3:1) bilayer were…”
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PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling by Yen, Hsin-Yung, Hoi, Kin Kuan, Liko, Idlir, Hedger, George, Horrell, Michael R., Song, Wanling, Wu, Di, Heine, Philipp, Warne, Tony, Lee, Yang, Carpenter, Byron, Plückthun, Andreas, Tate, Christopher G., Sansom, Mark S. P., Robinson, Carol V.

“…G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are therefore key drug targets 1 . Although detailed structural…”
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Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers by Koldsø, Heidi, Shorthouse, David, Hélie, Jean, Sansom, Mark S P

“…Cell membranes are complex multicomponent systems, which are highly heterogeneous in the lipid distribution and composition. To date, most molecular…”
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Structural basis of Smoothened regulation by its extracellular domains by Byrne, Eamon F. X., Sircar, Ria, Miller, Paul S., Hedger, George, Luchetti, Giovanni, Nachtergaele, Sigrid, Tully, Mark D., Mydock-McGrane, Laurel, Covey, Douglas F., Rambo, Robert P., Sansom, Mark S. P., Newstead, Simon, Rohatgi, Rajat, Siebold, Christian

“…Structural studies show that the activity of the G-protein-coupled receptor Smoothened is modulated by ligand-regulated interactions between its extracellular…”
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Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations by Lelimousin, Mickaël, Limongelli, Vittorio, Sansom, Mark S. P

“…The epidermal growth factor receptor (EGFR) is a dimeric membrane protein that regulates key aspects of cellular function. Activation of the EGFR is linked to…”
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A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates by Rao, Shanlin, Klesse, Gianni, Stansfeld, Phillip J., Tucker, Stephen J., Sansom, Mark S. P.

“…Ion channel proteins control ionic flux across biological membranes through conformational changes in their transmembrane pores. An exponentially increasing…”
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Structures of the otopetrin proton channels Otop1 and Otop3 by Saotome, Kei, Teng, Bochuan, Tsui, Che Chun (Alex), Lee, Wen-Hsin, Tu, Yu-Hsiang, Kaplan, Joshua P., Sansom, Mark S. P., Liman, Emily R., Ward, Andrew B.

“…Otopetrins (Otop1–Otop3) comprise one of two known eukaryotic proton-selective channel families. Otop1 is required for otoconia formation and a candidate…”
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A lipid gating mechanism for the channel-forming O antigen ABC transporter by Caffalette, Christopher A., Corey, Robin A., Sansom, Mark S. P., Stansfeld, Phillip J., Zimmer, Jochen

“…Extracellular glycan biosynthesis is a widespread microbial protection mechanism. In Gram-negative bacteria, the O antigen polysaccharide represents the…”
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Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs by Kumar, Arvind, Kindig, Kayla, Rao, Shanlin, Zaki, Afroditi-Maria, Basak, Sandip, Sansom, Mark S. P., Biggin, Philip C., Chakrapani, Sudha

“…Nociception and motor coordination are critically governed by glycine receptor (GlyR) function at inhibitory synapses. Consequentially, GlyRs are attractive…”
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Bendix: intuitive helix geometry analysis and abstraction by DAHL, Anna Caroline E, CHAVENT, Matthieu, SANSOM, Mark S. P

“…The flexibility of α-helices is important for membrane protein function and calls for better visualization and analysis. Software is presented that quantifies…”
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Membrane stiffness is modified by integral membrane proteins by Fowler, Philip W, Hélie, Jean, Duncan, Anna, Chavent, Matthieu, Koldsø, Heidi, Sansom, Mark S P

“…The ease with which a cell membrane can bend and deform is important for a wide range of biological functions. Peripheral proteins that induce curvature in…”
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Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1 by Shimamura, Tatsuro, Weyand, Simone, Beckstein, Oliver, Rutherford, Nicholas G, Hadden, Jonathan M, Sharples, David, Sansom, Mark S.P, Iwata, So, Henderson, Peter J.F, Cameron, Alexander D

“…The structure of the sodium-benzylhydantoin transport protein Mhp1 from Microbacterium liquefaciens comprises a five-helix inverted repeat, which is widespread…”
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A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel by Aryal, Prafulla, Abd-Wahab, Firdaus, Bucci, Giovanna, Sansom, Mark S. P., Tucker, Stephen J.

“…Recent X-ray crystal structures of the two-pore domain (K2P) family of potassium channels have revealed a unique structural architecture at the point where the…”
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Designing biomimetic pores based on carbon nanotubes by García-Fandiño, Rebeca, Sansom, Mark S. P

“…Biomimetic nanopores based on membrane-spanning single-walled carbon nanotubes have been designed to include selectivity filters based on combinations of…”
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Membrane Perturbation by Carbon Nanotube Insertion: Pathways to Internalization by Lelimousin, Mickaël, Sansom, Mark S. P.

“…Carbon nanotubes (CNTs) can penetrate the membranes of cells, offering prospects for nanomedicine but problems for nanotoxicity. Molecular simulations are used…”
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Lipid-Loving ANTs: Molecular Simulations of Cardiolipin Interactions and the Organization of the Adenine Nucleotide Translocase in Model Mitochondrial Membranes by Hedger, George, Rouse, Sarah L, Domański, Jan, Chavent, Matthieu, Koldsø, Heidi, Sansom, Mark S. P

“…The exchange of ADP and ATP across the inner mitochondrial membrane is a fundamental cellular process. This exchange is facilitated by the adenine nucleotide…”
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Structure and dynamics of the membrane-bound cytochrome P450 2C9 by Cojocaru, Vlad, Balali-Mood, Kia, Sansom, Mark S P, Wade, Rebecca C

“…The microsomal, membrane-bound, human cytochrome P450 (CYP) 2C9 is a liver-specific monooxygenase essential for drug metabolism. CYPs require electron transfer…”
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