Search Results - "Sansom, O J"

Microenvironmental cues in cancer stemness by Flanagan, D. J., Hodder, M. C., Sansom, O. J.

“…Intra-tumour heterogeneity manifests both at the level of mutational burden, and at a functional level within genetically homogenous populations. A new…”
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Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells by Huels, D. J., Bruens, L., Hodder, M. C., Cammareri, P., Campbell, A. D., Ridgway, R. A., Gay, D. M., Solar-Abboud, M., Faller, W. J., Nixon, C., Zeiger, L. B., McLaughlin, M. E., Morrissey, E., Winton, D. J., Snippert, H. J., van Rheenen, J., Sansom, O. J.

“…Many epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition…”
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Exploiting inflammation for therapeutic gain in pancreatic cancer by Steele, C W, Jamieson, N B, Evans, T R J, McKay, C J, Sansom, O J, Morton, J P, Carter, C R

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy associated with <5% 5-year survival, in which standard chemotherapeutics have limited…”
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Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors by Wilson, D. H., Jarman, E. J., Mellin, R. P., Wilson, M. L., Waddell, S. H., Tsokkou, P., Younger, N. T., Raven, A., Bhalla, S. R., Noll, A. T. R., Olde Damink, S. W., Schaap, F. G., Chen, P., Bates, D. O., Banales, J. M., Dean, C. H., Henderson, D. J., Sansom, O. J., Kendall, T. J., Boulter, L.

“…The number of patients diagnosed with chronic bile duct disease is increasing and in most cases these diseases result in chronic ductular scarring,…”
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Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine by Athineos, D, Sansom, O J

“…The adenomatous polyposis coli ( APC ) gene encodes APC tumour suppressor protein, germline mutation of which causes familial adenomatous polyposis, an…”
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Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia by Cordero, J. B., Sansom, O. J.

“…Adult stem cells are crucial for normal tissue homeostasis and regeneration upon damage. Deregulated stem cell proliferation and/or differentiation have been…”
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A RAC-GEF network critical for early intestinal tumourigenesis by Pickering, K. A., Gilroy, K., Cassidy, J. W., Fey, S. K., Najumudeen, A. K., Zeiger, L. B., Vincent, D. F., Gay, D. M., Johansson, J., Fordham, R. P., Miller, B., Clark, W., Hedley, A., Unal, E. B., Kiel, C., McGhee, E., Machesky, L. M., Nixon, C., Johnsson, A. E., Bain, M., Strathdee, D., van Hoof, S. R., Medema, J. P., Anderson, K. I., Brachmann, S. M., Stucke, V. M., Malliri, A., Drysdale, M., Turner, M., Serrano, L., Myant, K., Campbell, A. D., Sansom, O. J.

“…RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine…”
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NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression by McCall, P, Bennett, L, Ahmad, I, MacKenzie, L M, Forbes, I W G, Leung, H Y, Sansom, O J, Orange, C, Seywright, M, Underwood, M A, Edwards, J

“…Background: Cell line models suggest that activation of NF κ B is associated with progression of prostate cancer. This pathway may be a therapeutic target if…”
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Functions of TAp63 and p53 in restraining the development of metastatic cancer by Tan, E H, Morton, J P, Timpson, P, Tucci, P, Melino, G, Flores, E R, Sansom, O J, Vousden, K H, Muller, P A J

“…Many tumours harbour mutations in the p53 tumour-suppressor gene that result in the expression of a mutant p53 protein. This mutant p53 protein has, in most…”
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β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation by Ahmad, I, Morton, J P, Singh, L B, Radulescu, S M, Ridgway, R A, Patel, S, Woodgett, J, Winton, D J, Taketo, M M, Wu, X-R, Leung, H Y, Sansom, O J

“…Although deregulation of the Wnt signalling pathway has been implicated in urothelial cell carcinoma (UCC), the functional significance is unknown. To test its…”
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Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo by Phesse, T J, Myant, K B, Cole, A M, Ridgway, R A, Pearson, H, Muncan, V, van den Brink, G R, Vousden, K H, Sears, R, Vassilev, L T, Clarke, A R, Sansom, O J

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Absolute requirement for STAT3 function in small-intestine crypt stem cell survival by Matthews, J R, Sansom, O J, Clarke, A R

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Stem vs non-stem cell origin of colorectal cancer by Huels, D J, Sansom, O J

“…Colorectal cancer (CRC) is one of the most common cancers in the western world and is characterised by deregulation of the Wnt signalling pathway. Mutation of…”
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Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol by Radulescu, S, Ridgway, R A, Appleton, P, Kroboth, K, Patel, S, Woodgett, J, Taylor, S, Nathke, I S, Sansom, O J

“…Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling…”
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GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine by Ferro, R., Adamska, A., Lattanzio, R., Mavrommati, I., Edling, C. E., Arifin, S. A., Fyffe, C. A., Sala, G., Sacchetto, L., Chiorino, G., De Laurenzi, V., Piantelli, M., Sansom, O. J., Maffucci, T., Falasca, M.

“…The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are…”
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Calcium signalling links MYC to NUAK1 by Monteverde, T, Tait-Mulder, J, Hedley, A, Knight, J R, Sansom, O J, Murphy, D J

“…NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular…”
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53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy by CLARKE, A. R, JONES, N, PRYDE, F, ADACHI, Y, SANSOM, O. J

“…The p53-binding protein 53BP1 has been implicated in the DNA damage response and genomic instability. Previous reports have highlighted these roles in vivo in…”
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Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion by Muller, P A J, Trinidad, A G, Timpson, P, Morton, J P, Zanivan, S, van den Berghe, P V E, Nixon, C, Karim, S A, Caswell, P T, Noll, J E, Coffill, C R, Lane, D P, Sansom, O J, Neilsen, P M, Norman, J C, Vousden, K H

“…Tumour-derived mutant p53 proteins promote invasion, in part, by enhancing Rab coupling protein (RCP)-dependent receptor recycling. Here we identified MET as…”
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Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo by Phesse, T J, Myant, K B, Cole, A M, Ridgway, R A, Pearson, H, Muncan, V, van den Brink, G R, Vousden, K H, Sears, R, Vassilev, L T, Clarke, A R, Sansom, O J

“…Recent studies have suggested that C-MYC may be an excellent therapeutic cancer target and a number of new agents targeting C-MYC are in preclinical…”
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Absolute requirement for STAT3 function in small-intestine crypt stem cell survival by Matthews, J R, Sansom, O J, Clarke, A R

“…The transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated in human cancers. Interestingly, STAT3 also…”
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