Search Results - "Sansom, M S"

Chemical Reactions in 2D: Self-Assembly and Self-Esterification of 9(10),16-Dihydroxypalmitic Acid on Mica Surface by Heredia-Guerrero, J. A, San-Miguel, M. A, Sansom, M. S. P, Heredia, A, Benítez, J. J

“…9(10),16-Dihydroxypalmitic acid (diHPA) is a particularly interesting polyhydroxylated fatty acid (1) because it is the main monomer of cutin, the most…”
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Studies on viral fusion peptides: the distribution of lipophilic and electrostatic potential over the peptide determines the angle of insertion into a membrane by Taylor, A, Sansom, M. S. P

“…The oblique insertion of type 1 viral fusion peptides into the cell membrane of the host cell has been shown previously to be an essential element of viral…”
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Structure and function of channel-forming peptaibols by Sansom, M S

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Bundles Consisting of Extended Transmembrane Segments of Vpu from HIV-1:  Computer Simulations and Conductance Measurements by Cordes, F. S, Tustian, A. D, Sansom, M. S. P, Watts, A, Fischer, W. B

“…Part of the genome of the human immunodeficiency virus type 1 (HIV-1) encodes for a short membrane protein Vpu, which has a length of 81 amino acids. It has…”
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Transmembrane Peptide NB of Influenza B:  A Simulation, Structure, and Conductance Study by Fischer, W. B, Pitkeathly, M, Wallace, B. A, Forrest, L. R, Smith, G. R, Sansom, M. S. P

“…The putative transmembrane segment of the ion channel forming peptide NB from influenza B was synthesized by standard solid-phase peptide synthesis. Insertion…”
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On a novel rate theory for transport in narrow ion channels and its application to the study of flux optimization via geometric effects by Abad, E, Reingruber, J, Sansom, M S P

“…We present a novel rate theory based on the notions of splitting probability and mean first passage time to describe single-ion conduction in narrow,…”
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Voltage-Dependent Insertion of Alamethicin at Phospholipid/Water and Octane/Water Interfaces by Tieleman, D.P., Berendsen, H.J.C., Sansom, M.S.P.

“…Understanding the binding and insertion of peptides in lipid bilayers is a prerequisite for understanding phenomena such as antimicrobial activity and…”
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Ion-channel gating mechanisms: model identification and parameter estimation from single channel recordings by Ball, F. G., Sansom, M. S. P.

“…Patch-clamp data may be analysed in terms of Markov process models of channel gating mechanisms. We present a maximum likelihood algorithm for estimation of…”
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Ferrocenoyl Derivatives of Alamethicin:  Redox-Sensitive Ion Channels by Schmitt, Jeffrey D, Sansom, M. S. P, Kerr, I. D, Lunt, G. G, Eisenthal, R

“…The synthesis and single-channel characterization of two redox-active C-terminal derivatives of alamethicin are herein described. The reduced [Fe(II)] forms of…”
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The biophysics of peptide models of ion channels by Sansom, M S

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Alamethicin Pyromellitate: An Ion-Activated Channel-Forming Peptide by Woolley, G. Andrew, Epand, R. M, Kerr, I. D, Sansom, M. S. P, Wallace, B. A

“…The synthesis and characterization of alamethicin pyromellitate (Alm-PM), a derivative of the channel-forming peptide alamethicin bearing three negative…”
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Markov, fractal, diffusion, and related models of ion channel gating. A comparison with experimental data from two ion channels by Sansom, M.S., Ball, F.G., Kerry, C.J., McGee, R., Ramsey, R.L., Usherwood, P.N.

“…The gating kinetics of single-ion channels are generally modeled in terms of Markov processes with relatively small numbers of channel states. More recently,…”
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Cation selectivity in ion channels by Kerr, I. D, Sansom, M. S. P

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Ion-channel properties of mastoparan, a 14-residue peptide from wasp venom, and of MP3, a 12-residue analogue by Mellor, I. R., Sansom, M. S. P.

“…Mastoparan, a 14-residue peptide, has been investigated with respect to its ability to form ion channels in planar lipid bilayers. In the presence of 0.3 - 3.0…”
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Alamethicin Helices in a Bilayer and in Solution: Molecular Dynamics Simulations by Tieleman, D. Peter, Sansom, Mark S.P., Berendsen, Herman J.C.

“…Alamethicin is an α-helical channel-forming peptide, which inserts into lipid bilayers in a voltage-dependent, asymmetrical fashion. Nanosecond molecular…”
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Water at the nanoscale by Sansom, M S, Biggin, P C

“…One would not expect water to enter a hydrophobic carbon nanotube. But computer simulations show that it can, and studying the process should provide clues…”
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Single ion channel models incorporating aggregation and time interval omission by Ball, F.G., Yeo, G.F., Milne, R.K., Edeson, R.O., Madsen, B.W., Sansom, M.S.

“…We present a general theoretical framework, incorporating both aggregation of states into classes and time interval omission, for stochastic modeling of the…”
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Glutamate receptor channel kinetics: the effect of glutamate concentration by KERRY, C. J, RAMSEY, R. L, SANSOM, M. S. P, USHERWOOD, P. N. R

“…Single channel recordings from the locust muscle D-glutamate receptor channel were obtained using glutamate concentrations ranging from 10(-6) to 10(-2) M…”
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Ion Channel Gating and Time Interval Omission: Statistical Inference for a Two-State Markov Model by Ball, F. G., Davies, S. S., Sansom, M. S. P.

“…Statistical inference is considered for a two-state Markov model of a single ion channel, when time interval omission is incorporated. A simple method of…”
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Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics by Kerr, I.D., Sankararamakrishnan, R., Smart, O.S., Sansom, M.S.

“…A parallel bundle of transmembrane (TM) alpha-helices surrounding a central pore is present in several classes of ion channel, including the nicotinic…”
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