Search Results - "Sansom, J"

Mouse models of intestinal cancer by Jackstadt, Rene, Sansom, Owen J

“…Murine models of intestinal cancer are powerful tools to recapitulate human intestinal cancer, understand its biology and test therapies. With recent…”
Get full text

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration by Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M

“…Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of…”
Get full text

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids by Fumagalli, Arianna, Drost, Jarno, Suijkerbuijk, Saskia J. E., van Boxtel, Ruben, de Ligt, Joep, Offerhaus, G. Johan, Begthel, Harry, Beerling, Evelyne, Tan, Ee Hong, Sansom, Owen J., Cuppen, Edwin, Clevers, Hans, van Rheenen, Jacco

“…In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a set of defined mutations toward metastatic colorectal cancer (CRC)…”
Get full text

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties by Schwitalla, Sarah, Fingerle, Alexander A., Cammareri, Patrizia, Nebelsiek, Tim, Göktuna, Serkan I., Ziegler, Paul K., Canli, Ozge, Heijmans, Jarom, Huels, David J., Moreaux, Guenievre, Rupec, Rudolf A., Gerhard, Markus, Schmid, Roland, Barker, Nick, Clevers, Hans, Lang, Roland, Neumann, Jens, Kirchner, Thomas, Taketo, Makoto M., van den Brink, Gijs R., Sansom, Owen J., Arkan, Melek C., Greten, Florian R.

“…Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion between tumor-initiating stem cells and nonstem cells…”
Get full text

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy by Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

“…Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in…”
Get full text

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis by Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

“…The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in…”
Get full text

MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer by Valeri, Nicola, Braconi, Chiara, Gasparini, Pierluigi, Murgia, Claudio, Lampis, Andrea, Paulus-Hock, Viola, Hart, Jonathan R., Ueno, Lynn, Grivennikov, Sergei I., Lovat, Francesca, Paone, Alessio, Cascione, Luciano, Sumani, Khlea M., Veronese, Angelo, Fabbri, Muller, Carasi, Stefania, Alder, Hansjuerg, Lanza, Giovanni, Gafa’, Roberta, Moyer, Mary P., Ridgway, Rachel A., Cordero, Julia, Nuovo, Gerard J., Frankel, Wendy L., Rugge, Massimo, Fassan, Matteo, Groden, Joanna, Vogt, Peter K., Karin, Michael, Sansom, Owen J., Croce, Carlo M.

“…MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives…”
Get full text

A complex secretory program orchestrated by the inflammasome controls paracrine senescence by Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P., Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J., Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P., Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J., Longerich, Thomas, Sansom, Owen J., Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús

“…Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the…”
Get full text

In-situ measurement of internal gas pressure within cylindrical lithium-ion cells by Gulsoy, B., Vincent, T.A., Briggs, C., Sansom, J.E.H., Marco, J.

“…Internal gas pressure is a key parameter that varies depending on cell heating and gas formation over the lifetime of a lithium-ion cell under dynamic load…”
Get full text

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response by McGregor, Grace H, Campbell, Andrew D, Fey, Sigrid K, Tumanov, Sergey, Sumpton, David, Blanco, Giovanny Rodriguez, Mackay, Gillian, Nixon, Colin, Vazquez, Alexei, Sansom, Owen J, Kamphorst, Jurre J

“…Statins are widely prescribed inhibitors of the mevalonate pathway, acting to lower systemic cholesterol levels. The mevalonate pathway is critical for…”
Get full text

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer by Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

“…The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice…”
Get full text

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis by von Karstedt, Silvia, Conti, Annalisa, Nobis, Max, Montinaro, Antonella, Hartwig, Torsten, Lemke, Johannes, Legler, Karen, Annewanter, Franka, Campbell, Andrew D., Taraborrelli, Lucia, Grosse-Wilde, Anne, Coy, Johannes F., El-Bahrawy, Mona A., Bergmann, Frank, Koschny, Ronald, Werner, Jens, Ganten, Tom M., Schweiger, Thomas, Hoetzenecker, Konrad, Kenessey, Istvan, Hegedüs, Balazs, Bergmann, Michael, Hauser, Charlotte, Egberts, Jan-Hendrik, Becker, Thomas, Röcken, Christoph, Kalthoff, Holger, Trauzold, Anna, Anderson, Kurt I., Sansom, Owen J., Walczak, Henning

“…Many cancers harbor oncogenic mutations of KRAS. Effectors mediating cancer progression, invasion, and metastasis in KRAS-mutated cancers are only incompletely…”
Get full text

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease by Boulter, Luke, Govaere, Olivier, Bird, Tom G, Radulescu, Sorina, Ramachandran, Prakash, Pellicoro, Antonella, Ridgway, Rachel A, Seo, Sang Soo, Spee, Bart, Van Rooijen, Nico, Sansom, Owen J, Iredale, John P, Lowell, Sally, Roskams, Tania, Forbes, Stuart J

“…Hepatic precursor cells (HPCs) are known to be bipotent and to give rise to both new hepatocytes and cholangiocytes upon acute liver injury. Stuart J. Forbes…”
Get full text

Crypt stem cells as the cells-of-origin of intestinal cancer by van de Wetering, Marc, van Es, Johan H, Sansom, Owen J, Begthel, Harry, van den Born, Maaike, Barker, Nick, Danenberg, Esther, Clarke, Alan R, Clevers, Hans, Ridgway, Rachel A

“…Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin…”
Get full text

Neutrophils: Homing in on the myeloid mechanisms of metastasis by Leach, Joshua, Morton, Jennifer P., Sansom, Owen J.

“…•Neutrophils play important roles throughout the metastatic process.•Tumour progression and invasion are influenced by infiltrating neutrophils.•Signalling…”
Get full text

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis by Jamieson, Thomas, Clarke, Mairi, Steele, Colin W, Samuel, Michael S, Neumann, Jens, Jung, Andreas, Huels, David, Olson, Michael F, Das, Sudipto, Nibbs, Robert J B, Sansom, Owen J

“…The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through…”
Get full text

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma by Steele, Colin W., Karim, Saadia A., Leach, Joshua D.G., Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B., Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C. Ross, Balkwill, Frances, Chang, David K., Evans, T.R. Jeffry, Strathdee, Douglas, Biankin, Andrew V., Nibbs, Robert J.B., Barry, Simon T., Sansom, Owen J., Morton, Jennifer P.

“…CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties. Here we show that CXCR2 signaling is upregulated in human pancreatic…”
Get full text

Integrin signalling regulates YAP and TAZ to control skin homeostasis by Elbediwy, Ahmed, Vincent-Mistiaen, Zoé I, Spencer-Dene, Bradley, Stone, Richard K, Boeing, Stefan, Wculek, Stefanie K, Cordero, Julia, Tan, Ee H, Ridgway, Rachel, Brunton, Val G, Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J, Thompson, Barry J

“…The skin is a squamous epithelium that is continuously renewed by a population of basal layer stem/progenitor cells and can heal wounds. Here, we show that the…”
Get full text

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers by Muñoz, Javier, Stange, Daniel E, Schepers, Arnout G, van de Wetering, Marc, Koo, Bon-Kyoung, Itzkovitz, Shalev, Volckmann, Richard, Kung, Kevin S, Koster, Jan, Radulescu, Sorina, Myant, Kevin, Versteeg, Rogier, Sansom, Owen J, van Es, Johan H, Barker, Nick, van Oudenaarden, Alexander, Mohammed, Shabaz, Heck, Albert J R, Clevers, Hans

“…Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base columnar (CBC) cells and quiescent ‘+4’ cells. Here, we combine…”
Get full text

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression by Dozynkiewicz, Marta A., Jamieson, Nigel B., MacPherson, Iain, Grindlay, Joan, van den Berghe, Peter V.E., von Thun, Anne, Morton, Jennifer P., Gourley, Charlie, Timpson, Paul, Nixon, Colin, McKay, Colin J., Carter, Ross, Strachan, David, Anderson, Kurt, Sansom, Owen J., Caswell, Patrick T., Norman, Jim C.

“…Here we show that Rab25 permits the sorting of ligand-occupied, active-conformation α5β1 integrin to late endosomes/lysosomes. Photoactivation and biochemical…”
Get full text