Search Results - "Sankpal, Umesh T"

DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B by Palii, Stela S., Van Emburgh, Beth O., Sankpal, Umesh T., Brown, Kevin D., Robertson, Keith D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy by Sankpal, Umesh T, Maliakal, Pius, Bose, Debashish, Kayaleh, Omar, Buchholz, Daniel, Basha, Riyaz

“…Pancreatic cancer is an aggressive malignancy with poor prognosis. Pancreatic adenocarcinoma is one of the leading causes of cancer-related deaths in the…”
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Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors by Hurtado, Myrna, Sankpal, Umesh T., Kaba, Aboubacar, Mahammad, Shahela, Chhabra, Jaya, Brown, Deondra T., Gurung, Raj K., Holder, Alvin A., Vishwanatha, Jamboor K., Basha, Riyaz

“…Background/Aims: Targeting survivin, an anti-apoptotic protein and mitotic regulator, is considered as an effective therapeutic option for pancreatic cancer…”
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Role of KCNMA1 gene in breast cancer invasion and metastasis to brain by Khaitan, Divya, Sankpal, Umesh T, Weksler, Babette, Meister, Edward A, Romero, Ignacio A, Couraud, Pierre-Olivier, Ningaraj, Nagendra S

“…The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is…”
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Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors by Basha, Riyaz, Ingersoll, Susan B, Sankpal, Umesh T, Ahmad, Sarfraz, Baker, Cheryl H, Edwards, John R, Holloway, Robert W, Kaja, Sumanth, Abdelrahim, Maen

“…Abstract Objective The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a…”
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Environmental factors in causing human cancers: emphasis on tumorigenesis by Sankpal, Umesh T., Pius, Hima, Khan, Moeez, Shukoor, Mohammed I., Maliakal, Pius, Lee, Chris M., Abdelrahim, Maen, Connelly, Sarah F., Basha, Riyaz

“…The environment and dietary factors play an essential role in the etiology of cancer. Environmental component is implicated in ~80 % of all cancers; however,…”
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Cellular and Organismal Toxicity of the Anti-Cancer Small Molecule, Tolfenamic Acid: a Pre-Clinical Evaluation by Sankpal, Umesh T., Lee, Chris M., Connelly, Sarah F., Kayaleh, Omer, Eslin, Don, Sutphin, Robert, Goodison, Steven, Adwan, Lina, Zawia, Nasser H., Lichtenberger, Lenard M., Basha, Riyaz

“…Background/Aims: The small molecule, Tolfenamic acid (TA) has shown anti-cancer activity in pre-clinical models and is currently in Phase I clinical trials at…”
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Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model by Ningaraj, Nagendra S., Sankpal, Umesh T., Khaitan, Divya, Meister, Edward A., Vats, Tribhawan S.

“…Most anticancer drugs fail to impact patient survival since they fail to cross the blood-brain tumor barrier (BTB) at therapeutic levels. For example,…”
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Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro by Robertson, Andrea K., Geiman, Theresa M., Sankpal, Umesh T., Hager, Gordon L., Robertson, Keith D.

“…DNA methylation is an epigenetic modification of the genome critical for numerous processes, including transcriptional repression and maintenance of chromatin…”
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Impact of the Microbiome on the Immune System by Lambring, Christoffer B, Siraj, Sohail, Patel, Krishna, Sankpal, Umesh T, Mathew, Stephen, Basha, Riyaz

“…Higher organisms are all born with general immunity as well as with, increasingly, more specific immune systems. All immune mechanisms function with the intent…”
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Relevance of drug metabolizing enzyme activity modulation by tea polyphenols in the inhibition of esophageal tumorigenesis by Maliakal, Pius, Sankpal, Umesh T, Basha, Riyaz, Maliakal, Cima, Ledford, Andrea, Wanwimolruk, Sompon

“…Tea is a popular, socially accepted, drink that is enjoyed by millions of people. A growing body of evidence suggests that moderate consumption of tea may…”
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Combination of clotam and vincristine enhances anti-proliferative effect in medulloblastoma cells by Patil, Shruti, Sankpal, Umesh T., Hurtado, Myrna, Bowman, W. Paul, Murray, Jeffrey, Borgmann, Kathleen, Ghorpade, Anuja, Sutphin, Robert, Eslin, Don, Basha, Riyaz

“…Medulloblastoma (MB) is characterized by highly invasive embryonal neuro-epithelial tumors that metastasize via cerebrospinal fluid. MB is difficult to treat…”
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Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species by Sankpal, Umesh T, Nagaraju, Ganji Purnachandra, Gottipolu, Sriharika R, Hurtado, Myrna, Jordan, Christopher G, Simecka, Jerry W, Shoji, Mamoru, El-Rayes, Bassel, Basha, Riyaz

“…Curcumin (Cur) has been extensively studied in several types of malignancies including colorectal cancer (CRC); however its clinical application is greatly…”
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Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth by Shelake, Sagar, Sankpal, Umesh T., Paul Bowman, W., Wise, Matthew, Ray, Anish, Basha, Riyaz

“…Summary Transcription factor Specificity protein 1 (Sp1) and its downstream target survivin (inhibitor of apoptosis protein), play major roles in the…”
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Investigational agents to enhance the efficacy of chemotherapy or radiation in pancreatic cancer by Hurtado, Myrna, Sankpal, Umesh T., Ranjan, Amalendu, Maram, Rajasekhar, Vishwanatha, Jamboor K., Nagaraju, Ganji Purnachandra, El-Rayes, Bassel F., Basha, Riyaz

“…•Benefits of investigating the strategies to induce the efficacy of chemotherapy and or radiation.•Summary of investigational agents tested for inducing…”
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Copper-tolfenamic acid: evaluation of stability and anti-cancer activity by Hurtado, Myrna, Sankpal, Umesh T., Chhabra, Jaya, Brown, Deondra T., Maram, Rajasekhar, Patel, Rafid, Gurung, Raj K., Simecka, Jerry, Holder, Alvin A., Basha, Riyaz

“…Summary The non-steroidal anti-inflammatory drug, Tolfenamic acid (TA) acts as an anti-cancer agent in several adult and pediatric cancer models. Copper (Cu)…”
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Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells by Sankpal, Umesh T, Goodison, Steve, Jones-Pauley, Michelle, Hurtado, Myrna, Zhang, Fan, Basha, Riyaz

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are being tested extensively for their role in the treatment and prevention of several cancers. Typically NSAIDs…”
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Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution by Basha, Riyaz, Connelly, Sarah F., Sankpal, Umesh T., Nagaraju, Ganji Purnachandra, Patel, Hassaan, Vishwanatha, Jamboor K., Shelake, Sagar, Tabor-Simecka, Leslie, Shoji, Mamoru, Simecka, Jerry W., El-Rayes, Bassel

“…Combination of dietary/herbal spice curcumin (Cur) and COX inhibitors has been tested for improving therapeutic efficacy in pancreatic cancer (PC). The…”
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Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells by Hurtado, Myrna, Prokai, Laszlo, Sankpal, Umesh T., Levesque, Blair, Maram, Rajasekhar, Chhabra, Jaya, Brown, Deondra T., Gurung, Raj K., Holder, Alvin A., Vishwanatha, Jamboor K., Basha, Riyaz

“…[Display omitted] •Copper tolfenamic acid (CU-TA) exhibits anticancer activity against pancreatic cancer cells.•Next Generation Sequencing (NGS) results showed…”
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Targeted Molecular Therapeutic Options for Hepatocellular Carcinoma by Sridhar, Swathi, Sharma, Ishna, Sankpal, Umesh T, Ghabach, Bassam, Narra, Kalyani, Neerukonda, Latha, Basha, Riyaz

“…Liver cancer is the 6th leading cause of cancer related deaths in the US even though it ranks 14th in incidence. More men are diagnosed with liver cancer than…”
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