Search Results - "Sankaran, Sandhya"

Artificial protein sequences enable recognition of vicinal and distant protein functional relationships by Kumar, Gayatri, Srinivasan, Narayanaswamy, Sandhya, Sankaran

“…High divergence in protein sequences makes the detection of distant protein relationships through homology‐based approaches challenging. Grouping protein…”
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Signatures of conserved and unique molecular features in Afrotheria by Yazhini, Arangasamy, Srinivasan, Narayanaswamy, Sandhya, Sankaran

“…Afrotheria is a clade of African-origin species with striking dissimilarities in appearance and habitat. In this study, we compared whole proteome sequences of…”
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Molecular dynamics and docking studies on potentially active natural phytochemicals for targeting SARS-CoV-2 main protease by Karakkadparambil Sankaran, Sandhya, Nair, Achuthsankar S.

“…In the present study, we screened eighty seven novel phytochemical compounds from four popular herbs, such as, Aegle Marmelos, Coleus Amboinicus, Aerva Lanata…”
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Domain architecture of BAF250a reveals the ARID and ARM-repeat domains with implication in function and assembly of the BAF remodeling complex by Sandhya, Sankaran, Maulik, Aditi, Giri, Malyasree, Singh, Mahavir

“…BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that recruit the complex to chromatin allowing transcriptional activation of…”
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Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair by Tandon, Himani, Sharma, Arun, Sandhya, Sankaran, Srinivasan, Narayanaswamy, Singh, Ramandeep

“…Toxin-antitoxin (TA) systems are ubiquitously existing addiction modules with essential roles in bacterial persistence and virulence. The genome of…”
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Sequence Divergence and Functional Specializations of the Ancient Spliceosomal SF3b: Implications in Flexibility and Adaptations of the Multi-Protein Complex by Yazhini, Arangasamy, Srinivasan, Narayanaswamy, Sandhya, Sankaran

“…Multi-protein assemblies are complex molecular systems that perform highly sophisticated biochemical functions in an orchestrated manner. They are subject to…”
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Computational tools to study RNA-protein complexes by Bheemireddy, Sneha, Sandhya, Sankaran, Srinivasan, Narayanaswamy, Sowdhamini, Ramanathan

“…RNA is the key player in many cellular processes such as signal transduction, replication, transport, cell division, transcription, and translation. These…”
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Use of designed sequences in protein structure recognition by Kumar, Gayatri, Mudgal, Richa, Srinivasan, Narayanaswamy, Sandhya, Sankaran

“…Knowledge of the protein structure is a pre-requisite for improved understanding of molecular function. The gap in the sequence-structure space has increased…”
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Revisiting the Stereochemistry of Propylene Isotactic Polymerization Reaction Mechanism on C2 Symmetric [SiH2(Ind)2ZrCH3]+ and [SiH2(Ind)2ZrCH3]+[CH3B(C6F5)3] by Karakkadparambil, Sankaran Sandhya, Koga, Nobuaki, Nagaoka, Masataka

“…The [SiH2(Ind)2ZrCH3]+ (Ind = indenyl) catalyzed stereoregularity of propylene polymerization mechanism has been investigated at M06 level of theory. Four…”
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Comparative Analysis of Structural and Dynamical Features of Ribosome Upon Association With mRNA Reveals Potential Role of Ribosomal Proteins by Bheemireddy, Sneha, Sandhya, Sankaran, Srinivasan, Narayanaswamy

“…Ribosomes play a critical role in maintaining cellular proteostasis. The binding of messenger RNA (mRNA) to the ribosome regulates kinetics of protein…”
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Molecular and Structural Basis of Cross-Reactivity in M. tuberculosis Toxin-Antitoxin Systems by Tandon, Himani, Melarkode Vattekatte, Akhila, Srinivasan, Narayanaswamy, Sandhya, Sankaran

“…genome encodes over 80 toxin-antitoxin (TA) systems. While each toxin interacts with its cognate antitoxin, the abundance of TA systems presents an opportunity…”
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Transformation of Metallic Ti to TiH2 Phase in the Ti/MgH2 Composite and Its Influence on the Hydrogen Storage Behavior of MgH2 by Pukazhselvan, D., Sandhya, Karakkadparambil Sankaran, Ramasamy, Devaraj, Shaula, Aliaksandr, Fagg, Duncan Paul

“…The current work explores the in‐situ formation of TiH2 additive in a Ti/MgH2 nanocomposite system. Mild mechanical milling leaves Ti chemically unchanged,…”
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Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes by Yazhini, Arangasamy, Sandhya, Sankaran, Srinivasan, Narayanaswamy

“…The evolution of homologous and functionally equivalent multiprotein assemblies is intriguing considering sequence divergence of constituent proteins. Here, we…”
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Improved detection of remote homologues using cascade PSI-BLAST: influence of neighbouring protein families on sequence coverage by Kaushik, Swati, Mutt, Eshita, Chellappan, Ajithavalli, Sankaran, Sandhya, Srinivasan, Narayanaswamy, Sowdhamini, Ramanathan

“…Development of sensitive sequence search procedures for the detection of distant relationships between proteins at superfamily/fold level is still a big…”
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Synthesis and Anticancer Evaluation of Tryptanthrin‐1,2,3‐Triazole Hybrids by Meenakshy, C. B., Sruthi, Sudheendran Leena, Jayasree, E. G., Sandhya, Karakkadparambil Sankaran, Deepthi, Ani

“…ABSTRACT Synthesis of 18 tryptanthrin‐triazole hybrid molecules by employing Cu(I)‐catalyzed azide‐alkyne [3 + 2] cycloaddition (CuAAC) between tryptanthrin…”
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Structural annotation of Mycobacterium tuberculosis proteome by Anand, Praveen, Sankaran, Sandhya, Mukherjee, Sumanta, Yeturu, Kalidas, Laskowski, Roman, Bhardwaj, Anshu, Bhagavat, Raghu, Brahmachari, Samir K, Chandra, Nagasuma

“…Of the ∼4000 ORFs identified through the genome sequence of Mycobacterium tuberculosis (TB) H37Rv, experimentally determined structures are available for 312…”
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An Active Site Opening Mechanism in a (Pyridylamide)hafnium(IV) Ion Pair Catalyst: An Associative Mechanism by Matsumoto, Kentaro, Sandhya, Karakkadparambil Sankaran, Takayanagi, Masayoshi, Koga, Nobuaki, Nagaoka, Masataka

“…We report a molecular dynamics (MD) study on the ion pair [{N–,N,C–}­HfMe]­[MeB­(C6F5)3], which is the active species of a (pyridylamide)­hafnium­(IV) complex…”
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Length variations amongst protein domain superfamilies and consequences on structure and function by Sandhya, Sankaran, Rani, Saane Sudha, Pankaj, Barah, Govind, Madabosse Kande, Offmann, Bernard, Srinivasan, Narayanaswamy, Sowdhamini, Ramanathan

“…Related protein domains of a superfamily can be specified by proteins of diverse lengths. The structural and functional implications of indels in a domain…”
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Probing the Most Stable Isomer of Zirconium Bis(phenoxy-imine) Cation: A Computational Investigation by Saha, Soumen, Takayanagi, Masayoshi, Matsumoto, Kentaro, Sankaran, Sandhya Karakkadparambil, Tanaka, Yuichi, Koga, Nobuaki, Nagaoka, Masataka

“…The possibility of coexistence of multiple isomers for zirconium bis­(phenoxy-imine) catalyst has been systematically studied by computational approaches. The…”
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Subjective symptoms of carpal tunnel syndrome correlate more with psychological factors than electrophysiological severity by Khan, Firosh, Shehna, Abdulkhader, Ramesh, Sivaramakrishnan, Sandhya, Kakkassery, Paul, Reji

“…Aim: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and is one of the most common requests for electrodiagnosis. We aimed to note the…”
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