Search Results - "Sankar, Krishana S"

Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function by Sankar, Krishana S, Altamentova, Svetlana M, Rocheleau, Jonathan V

“…Pancreatic islets are heavily vascularized in vivo yet lose this vasculature after only a few days in culture. Determining how to maintain islet vascularity in…”
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Culturing pancreatic islets in microfluidic flow enhances morphology of the associated endothelial cells by Sankar, Krishana S, Green, Brenda J, Crocker, Alana R, Verity, Jocelyne E, Altamentova, Svetlana M, Rocheleau, Jonathan V

“…Pancreatic islets are heavily vascularized in vivo with each insulin secreting beta-cell associated with at least one endothelial cell (EC). This structure is…”
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Allosteric modulation in monomers and oligomers of a G protein-coupled receptor by Shivnaraine, Rabindra V, Kelly, Brendan, Sankar, Krishana S, Redka, Dar'ya S, Han, Yi Rang, Huang, Fei, Elmslie, Gwendolynne, Pinto, Daniel, Li, Yuchong, Rocheleau, Jonathan V, Gradinaru, Claudiu C, Ellis, John, Wells, James W

“…The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown…”
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Single-Molecule Analysis of the Supramolecular Organization of the M2 Muscarinic Receptor and the Gαi1 Protein by Shivnaraine, Rabindra V, Fernandes, Dennis D, Ji, Huiqiao, Li, Yuchong, Kelly, Brendan, Zhang, Zhenfu, Han, Yi Rang, Huang, Fei, Sankar, Krishana S, Dubins, David N, Rocheleau, Jonathan V, Wells, James W, Gradinaru, Claudiu C

“…G protein-coupled receptors constitute the largest family of transmembrane signaling proteins and the largest pool of drug targets, yet their mechanism of…”
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LKB1 couples glucose metabolism to insulin secretion in mice by Fu, Accalia, Robitaille, Karine, Faubert, Brandon, Reeks, Courtney, Dai, Xiao-Qing, Hardy, Alexandre B., Sankar, Krishana S., Ogrel, Svetlana, Al-Dirbashi, Osama Y., Rocheleau, Jonathan V., Wheeler, Michael B., MacDonald, Patrick E., Jones, Russell, Screaton, Robert A.

“…Aims/hypothesis Precise regulation of insulin secretion by the pancreatic beta cell is essential for the maintenance of glucose homeostasis. Insulin secretory…”
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Single-Molecule Analysis of the Supramolecular Organization of the M 2 Muscarinic Receptor and the Gα i1 Protein by Shivnaraine, Rabindra V., Fernandes, Dennis D., Ji, Huiqiao, Li, Yuchong, Kelly, Brendan, Zhang, Zhenfu, Han, Yi Rang, Huang, Fei, Sankar, Krishana S., Dubins, David N., Rocheleau, Jonathan V., Wells, James W., Gradinaru, Claudiu C.

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Single-Molecule Study of the Oligomeric States of the M2 Muscarinic Receptor, the Gi1 Protein and the M2-Gi1 Complex by Fernandes, Dennis D., Shivnaraine, Rabindra V., Li, Yuchong, Huiqiao, Ji, Zhang, Zhenfu, Kelly, Brendan, Han, Nellie, Huang, Fei, Sankar, Krishana S., Rocheleau, Jonathon V., Wells, James W., Gradinaru, Claudiu C.

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