Search Results - "Sanguigno, Luca"

Emerging Role of DREAM in Healthy Brain and Neurological Diseases by Molinaro, Pasquale, Sanguigno, Luca, Casamassa, Antonella, Valsecchi, Valeria, Sirabella, Rossana, Pignataro, Giuseppe, Annunziato, Lucio, Formisano, Luigi

“…The downstream regulatory element antagonist modulator (DREAM) is a multifunctional Ca -sensitive protein exerting a dual mechanism of action to regulate…”
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Triticum vulgare extract exerts an anti-inflammatory action in two in vitro models of inflammation in microglial cells by Sanguigno, Luca, Casamassa, Antonella, Funel, Niccola, Minale, Massimiliano, Riccio, Rodolfo, Riccio, Salvatore, Boscia, Francesca, Brancaccio, Paola, Pollina, Luca Emanuele, Anzilotti, Serenella, Di Renzo, Gianfranco, Cuomo, Ornella

“…Triticum vulgare has been extensively used in traditional medicine thanks to its properties of accelerating tissue repair. The specific extract of Triticum…”
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Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry by Sivaccumar, Jwala Priyadarsini, Leonardi, Antonio, Iaccarino, Emanuela, Corvino, Giusy, Sanguigno, Luca, Chambery, Angela, Russo, Rosita, Valletta, Mariangela, Latino, Debora, Capasso, Domenica, Doti, Nunzianna, Ruvo, Menotti, Sandomenico, Annamaria

“…Monoclonal antibodies (mAbs) against cancer biomarkers are key reagents in diagnosis and therapy. One such relevant biomarker is a preferentially expressed…”
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Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex by Guida, Natascia, Serani, Angelo, Sanguigno, Luca, Mascolo, Luigi, Cuomo, Ornella, Fioriniello, Salvatore, Marano, Domenico, Ragione, Floriana Della, Anzilotti, Serenella, Brancaccio, Paola, Molinaro, Pasquale, Pignataro, Giuseppe, Annunziato, Lucio, Formisano, Luigi

“…REST (Repressor-Element 1 [RE1]-silencing transcription factor) inhibits Na /Ca exchanger-1 ( ) transcription in neurons through the binding of RE1 site on…”
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The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates Methylmercury-Induced Cell Death in Motor Neuron-Like NSC34 Cells Overexpressing SOD1-G93A by Guida, Natascia, Sanguigno, Luca, Mascolo, Luigi, Calabrese, Lucrezia, Serani, Angelo, Molinaro, Pasquale, Lau, C Geoffrey, Annunziato, Lucio, Formisano, Luigi

“…Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been…”
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New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding by Focà, Annalia, Sanguigno, Luca, Focà, Giuseppina, Strizzi, Luigi, Iannitti, Roberta, Palumbo, Rosanna, Hendrix, Mary J C, Leonardi, Antonio, Ruvo, Menotti, Sandomenico, Annamaria

“…Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the…”
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Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death by Sanguigno, Luca, Guida, Natascia, Anzilotti, Serenella, Cuomo, Ornella, Mascolo, Luigi, Serani, Angelo, Brancaccio, Paola, Pennacchio, Giuseppina, Licastro, Ester, Pignataro, Giuseppe, Molinaro, Pasquale, Annunziato, Lucio, Formisano, Luigi

“…The inhibition of histone deacetylase 9 (HDAC9) represents a promising druggable target for stroke intervention. Indeed, HDAC9 is overexpressed in neurons…”
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Development of conformational antibodies targeting Cripto-1 with neutralizing effects in vitro by Focà, Giuseppina, Iaccarino, Emanuela, Focà, Annalia, Sanguigno, Luca, Untiveros, Gustavo, Cuevas-Nunez, Maria, Strizzi, Luigi, Leonardi, Antonio, Ruvo, Menotti, Sandomenico, Annamaria

“…Human Cripto-1 (Cripto-1), the founding member of the EGF-CFC superfamily, is a key regulator of many processes during embryonic development and oncogenesis…”
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Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422 by Sandomenico, Annamaria, Leonardi, Antonio, Berisio, Rita, Sanguigno, Luca, Focà, Giuseppina, Focà, Annalia, Ruggiero, Alessia, Doti, Nunzianna, Muscariello, Livio, Barone, Daniela, Farina, Claudio, Owsianka, Ania, Vitagliano, Luigi, Patel, Arvind H, Ruvo, Menotti

“…The hepatitis C virus (HCV) E2 envelope glycoprotein is crucial for virus entry into hepatocytes. A conserved region of E2 encompassing amino acids 412 to 423…”
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NGAL Controls the Metastatic Potential of Anaplastic Thyroid Carcinoma Cells by Volpe, Vincenzo, Raia, Zelinda, Sanguigno, Luca, Somma, Domenico, Mastrovito, Paola, Moscato, Fortunato, Mellone, Stefano, Leonardi, Antonio, Pacifico, Francesco

“…Context: We have previously identified neutrophil gelatinase-associated lipocalin (NGAL) as one of the genes mediating the oncogenic activity of nuclear…”
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Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions by Sanguigno, Luca, Minale, Massimiliano, Vannini, Ernesto, Arato, Guido, Riccio, Rodolfo, Casapullo, Agostino, Monti, Maria Chiara, Riccio, Raffaele, Formisano, Silvestro, Di Renzo, Gianfranco, Cuomo, Ornella

“…Triticum vulgare has been extensively used in traditional medicine thanks to its properties of accelerating tissue repair. The aqueous extract of Triticum…”
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The chemokine scavenging receptor D6/ACKR2 is a target of miR-146a in thyroid cancer by Pacifico, Francesco, Lepore, Alessio, Mellone, Stefano, Sanguigno, Luca, Federico, Giorgia, Greco, Adelaide, Brunetti, Arturo, Leonardi, Antonio

“…We have previously shown that miR-146a, a NF-κB-regulated microRNA, is strongly expressed in human specimens and cell lines derived from anaplastic thyroid…”
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Effects of a novel Nodal-targeting monoclonal antibody in melanoma by Strizzi, Luigi, Sandomenico, Annamaria, Margaryan, Naira V, Focà, Annalia, Sanguigno, Luca, Bodenstine, Thomas M, Chandler, Grace S, Reed, David W, Gilgur, Alina, Seftor, Elisabeth A, Seftor, Richard E B, Khalkhali-Ellis, Zhila, Leonardi, Antonio, Ruvo, Menotti, Hendrix, Mary J C

“…Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the…”
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Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen by Sandomenico, Annamaria, Focà, Annalia, Sanguigno, Luca, Caporale, Andrea, Focà, Giuseppina, Pignalosa, Angelica, Corvino, Giusy, Caragnano, Angela, Beltrami, Antonio Paolo, Antoniali, Giulia, Tell, Gianluca, Leonardi, Antonio, Ruvo, Menotti

“…Post-translational modifications (PTMs) strongly influence the structure and function of proteins. Lysine side chain acetylation is one of the most widespread…”
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Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen by Sandomenico, Annamaria, Focà, Annalia, Sanguigno, Luca, Caporale, Andrea, Focà, Giuseppina, Pignalosa, Angelica, Corvino, Giusy, Caragnano, Angela, Beltrami, Antonio Paolo, Antoniali, Giulia, Tell, Gianluca, Leonardi, Antonio, Ruvo, Menotti

“…Post-translational modifications (PTMs) strongly influence the structure and function of proteins. Lysine side chain acetylation is one of the most widespread…”
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