Search Results - "Sanghai, Nitesh"

Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View by Sanghai, Nitesh, Tranmer, Geoffrey K

“…Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of…”
Get full text

Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology by Sanghai, Nitesh, Tranmer, Geoffrey K

“…Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) inside living cells and are implicated in the pathogenesis of…”
Get full text

Drug Discovery by Drug Repurposing: Combating COVID-19 in the 21st Century by Sanghai, Nitesh, Shafiq, Kashfia, Tranmer, Geoffrey K

“…Due to the rapidly developing nature of the current COVID-19 outbreak and its almost immediate humanitarian and economic toll, coronavirus drug discovery…”
Get more information

ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging by Guo, Ying, Guan, Teng, Yu, Qiang, Sanghai, Nitesh, Shafiq, Kashfia, Li, Meiyu, Jiao, Xin, Na, Donghui, Zhang, Guohui, Kong, Jiming

“…Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling correlative data have been generated to support the OS theory, a direct…”
Get full text

Implication of post-translationally modified SOD1 in pathological aging by Shafiq, Kashfia, Sanghai, Nitesh, Guo, Ying, Kong, Jiming

“…Why certain people relish healthy aging throughout their life span while others suffer pathological consequences? In this review, we focus on some of the…”
Get full text

Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms by Sanghai, Nitesh, Tranmer, Geoffrey K.

“…[Display omitted] •Hyperinflammatory cytokine profile is a serious complication of SARS-CoV-2 infections.•COVID-19 can result in a ‘cytokine storm’ that leads…”
Get full text

Current Small Molecule-Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics by Sanghai, Nitesh, Vuong, Billy, Burak Berk, Ahmet, Afridi, Muhammad Shaharyar K, Tranmer, Geoffrey K

“…Neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic lateral sclerosis (ALS) possess multifactorial…”
Get full text