Search Results - "Sanger, Helen"
-
1
Feasibility of mobilisation in ICU: a multi-centre point prevalence study of mobility practices in the UK
Published in Critical care (London, England) (01-06-2023)“…Early mobilisation in critical care is recommended within clinical guidance; however, mobilisation prevalence across the UK is unknown. The study aimed to…”
Get full text
Journal Article -
2
Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases
Published in Neuropharmacology (01-07-2018)“…The cholinergic signalling system has been an attractive pathway to seek targets for modulation of arousal, cognition, and attention which are compromised in…”
Get full text
Journal Article -
3
The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Published in Experimental physiology (01-01-2024)“…A metabotropic glutamate receptor coupled to phospholipase D (PLD‐mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct…”
Get full text
Journal Article -
4
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
Published in The Journal of clinical investigation (01-02-2017)“…The current frontline symptomatic treatment for Alzheimer's disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of…”
Get full text
Journal Article -
5
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
Published in Cerebral cortex (New York, N.Y. 1991) (01-01-2016)“…Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory…”
Get full text
Journal Article -
6
Recovery, rehabilitation and follow-up services following critical illness: an updated UK national cross-sectional survey and progress report
Published in BMJ open (04-10-2021)“…ObjectiveTo comprehensively update and survey the current provision of recovery, rehabilitation and follow-up services for adult critical care patients across…”
Get full text
Journal Article -
7
Bitopic Binding Mode of an M 1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
Published in Molecular pharmacology (01-06-2018)“…The realization of the therapeutic potential of targeting the M muscarinic acetylcholine receptor (mAChR) for the treatment of cognitive decline in Alzheimer's…”
Get more information
Journal Article -
8
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors
Published in British journal of pharmacology (01-01-2019)“…Background and Purpose We aimed to identify and develop novel, selective muscarinic M1 receptor agonists as potential therapeutic agents for the symptomatic…”
Get full text
Journal Article -
9
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist
Published in Neuropharmacology (15-03-2017)“…Metabotropic glutamate 2/3 (mGlu2/3) receptors are of considerable interest owing to their role in modulating glutamate transmission via presynaptic,…”
Get full text
Journal Article -
10
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist
Published in Neuropharmacology (01-03-2017)“…Metabotropic glutamate (mGlu ) receptors are of considerable interest owing to their role in modulating glutamate transmission via presynaptic, postsynaptic…”
Get full text
Journal Article -
11
Dyspnoea in intensive care unit: a truly multi-professional problem
Published in Intensive care medicine (01-07-2024)Get full text
Journal Article -
12
Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation
Published in The Journal of pharmacology and experimental therapeutics (01-11-2022)“…Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated human tau (TgP301S and Tg4510) and brains of patients with…”
Get full text
Journal Article -
13
Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a
Published in Psychopharmacology (01-06-2017)“…Rationale Major depressive disorder is a leading cause of suicide and disability. Despite this, current antidepressants provide insufficient efficacy in more…”
Get full text
Journal Article -
14
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Published in Journal of medicinal chemistry (26-02-2015)Get full text
Journal Article -
15
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M 1 receptors
Published in British journal of pharmacology (01-01-2019)“…We aimed to identify and develop novel, selective muscarinic M receptor agonists as potential therapeutic agents for the symptomatic treatment of Alzheimer's…”
Get full text
Journal Article -
16
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Published in Journal of medicinal chemistry (26-02-2015)“…As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the…”
Get full text
Journal Article -
17
Pharmacological profiling of the TRPV3 channel in recombinant and native assays
Published in British journal of pharmacology (01-05-2014)“…Background and Purpose Transient receptor potential vanilloid subtype 3 (TRPV3) is implicated in nociception and certain skin conditions. As such, it is an…”
Get full text
Journal Article -
18
Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR
Published in Neuropharmacology (01-03-2013)“…The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential…”
Get full text
Journal Article -
19
REGULATED RELEASE OF HYPER-PHOSPHORYLATED, AGGREGATED AND SEEDING COMPETENT TAU FROM RODENT BRAINS AND HUMAN SYNAPTOSOMES
Published in Alzheimer's & dementia (01-07-2017)Get full text
Journal Article