Search Results - "Sanganalmath, Santosh K."

The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy by Sanganalmath, Santosh K, Dubey, Shubham, Veeranki, Sudhakar, Narisetty, Keerthy, Krishnamurthy, Prasanna

“…Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is linked with high morbidity and mortality. Diabetic…”
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Intracoronary Delivery of Autologous Cardiac Stem Cells Improves Cardiac Function in a Porcine Model of Chronic Ischemic Cardiomyopathy by Bolli, Roberto, Tang, Xian-Liang, Sanganalmath, Santosh K, Rimoldi, Ornella, Mosna, Federico, Abdel-Latif, Ahmed, Jneid, Hani, Rota, Marcello, Leri, Annarosa, Kajstura, Jan

“…BACKGROUND—Relevant preclinical models are necessary for further mechanistic and translational studies of c-kit+ cardiac stem cells (CSCs). The present study…”
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Cell Therapy for Heart Failure: A Comprehensive Overview of Experimental and Clinical Studies, Current Challenges, and Future Directions by Sanganalmath, Santosh K., Bolli, Roberto

“…Despite significant therapeutic advances, the prognosis of patients with heart failure (HF) remains poor, and current therapeutic approaches are palliative in…”
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A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning by Bolli, Roberto, Stein, Adam B, Guo, Yiru, Wang, Ou-Li, Rokosh, Gregg, Dawn, Buddhadeb, Molkentin, Jeffery D, Sanganalmath, Santosh K, Zhu, Yanqing, Xuan, Yu-Ting

“…Abstract Pharmacological studies have shown that signal transducers and activators of transcription (STATs) are necessary for the delayed cardioprotection of…”
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Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium by Stein, Adam B, Bolli, Roberto, Dawn, Buddhadeb, Sanganalmath, Santosh K, Zhu, Yanqing, Wang, Ou-Li, Guo, Yiru, Motterlini, Roberto, Xuan, Yu-Ting

“…Abstract A growing body of evidence indicates that carbon monoxide (CO), once perceived merely as a poisonous gas, exerts antiapoptotic and cytoprotective…”
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Activation of Cardiac Progenitor Cells Reverses the Failing Heart Senescent Phenotype and Prolongs Lifespan by Gonzalez, Arantxa, Rota, Marcello, Nurzynska, Daria, Misao, Yu, Tillmanns, Jochen, Ojaimi, Caroline, Padin-Iruegas, M Elena, Müller, Patrick, Esposito, Grazia, Bearzi, Claudia, Vitale, Serena, Dawn, Buddhadeb, Sanganalmath, Santosh K, Baker, Mathue, Hintze, Thomas H, Bolli, Roberto, Urbanek, Konrad, Hosoda, Toru, Anversa, Piero, Kajstura, Jan, Leri, Annarosa

“…Heart failure is the leading cause of death in the elderly, but whether this is the result of a primary aging myopathy dictated by depletion of the cardiac…”
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Transplantation of Bone Marrow‐Derived Very Small Embryonic‐Like Stem Cells Attenuates Left Ventricular Dysfunction and Remodeling After Myocardial Infarction by Dawn, Buddhadeb, Tiwari, Sumit, Kucia, Magdalena J., Zuba‐Surma, Ewa K., Guo, Yiru, SanganalMath, Santosh K., Abdel‐Latif, Ahmed, Hunt, Greg, Vincent, Robert J., Taher, Hisham, Reed, Nathan J., Ratajczak, Mariusz Z., Bolli, Roberto

“…Adult bone marrow (BM) contains Sca‐1+/Lin−/CD45− very small embryonic‐like stem cells (VSELs) that express markers of several lineages, including cardiac…”
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Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond by Sanganalmath, Santosh K., Abdel-Latif, Ahmed, Bolli, Roberto, Xuan, Yu-Ting, Dawn, Buddhadeb

“…Hematopoietic cytokines, traditionally known to influence cellular proliferation, differentiation, maturation, and lineage commitment in the bone marrow,…”
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Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction by Tang, Xian-Liang, Sanganalmath, Santosh K, Sato, Hiroshi, Bi, Qiuli, Hunt, Greg, Vincent, Robert J, Peng, Yong, Shirk, Gregg, Dawn, Buddhadeb, Bolli, Roberto

“…Although statins impart a number of cardiovascular benefits, whether statin therapy during the peri-infarct period improves subsequent myocardial structure and…”
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Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year by Tang, Xian-Liang, Li, Qianhong, Rokosh, Gregg, Sanganalmath, Santosh K, Chen, Ning, Ou, Qinghui, Stowers, Heather, Hunt, Greg, Bolli, Roberto

“…Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5…”
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Intracoronary Administration of Cardiac Progenitor Cells Alleviates Left Ventricular Dysfunction in Rats With a 30-Day-Old Infarction by TANG, Xian-Liang, ROKOSH, Gregg, DAWN, Buddhadeb, HUNT, Greg, LERI, Annarosa, KAJSTURA, Jan, TIWARI, Sumit, SHIRK, Gregg, ANVERSA, Piero, BOLLI, Roberto, SANGANALMATH, Santosh K, FANGPING YUAN, SATO, Hiroshi, JIANYAO MU, SHUJING DAI, CHENGXIN LI, NING CHEN, YONG PENG

“…Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusion ameliorates left ventricular function in rats with acute myocardial infarction…”
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The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up by Sanganalmath, Santosh K, Stein, Adam B, Guo, Yiru, Tiwari, Sumit, Hunt, Greg, Vincent, Robert J, Huang, Yiming, Rezazadeh, Arash, Ildstad, Suzanne T, Dawn, Buddhadeb, Bolli, Roberto

“…Abstract We have previously reported that administration of granulocyte colony-stimulating factor (G-CSF) + Flt-3 ligand (FL) or G-CSF + stem cell factor (SCF)…”
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Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities by Sanganalmath, Santosh K., Gopal, Purva, Parker, John R., Downs, Richard K., Parker, Joseph C., Dawn, Buddhadeb

“…Circulatory arrest (CA) remains a major unresolved public health problem in the United States; the annual incidence of which is ~0.50 to 0.55 per 1000…”
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Efficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials by Ganda, Om P., Plutzky, Jorge, Sanganalmath, Santosh K., Bujas‐Bobanovic, Maja, Koren, Andrew, Mandel, Jonas, Letierce, Alexia, Leiter, Lawrence A.

“…Aims Individuals with both diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD) are at very high risk of cardiovascular events. This…”
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Efficacy and Safety of Alirocumab in High-Risk Patients With Clinical Atherosclerotic Cardiovascular Disease and/or Heterozygous Familial Hypercholesterolemia (from 5 Placebo-Controlled ODYSSEY Trials) by McCullough, Peter A., Ballantyne, Christie M., Sanganalmath, Santosh K., Langslet, Gisle, Baum, Seth J., Shah, Prediman K., Koren, Andrew, Mandel, Jonas, Davidson, Michael H.

“…Patients with previous atherosclerotic cardiovascular disease (ASCVD) and/or heterozygous familial hypercholesterolemia (HeFH) are at high risk of future…”
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Antiplatelet Agents Sarpogrelate and Cilostazol Affect Experimentally-induced Ventricular Arrhythmias and Mortality by Barta, Judit, Sanganalmath, Santosh K., Kumamoto, Hideo, Takeda, Nobuakira, Édes, István, Dhalla, Naranjan S.

“…Antiplatelet agents, sarpogrelate (SAR), a 5-hydroxy tryptamine 2A receptor antagonist and cilostazol (CIL), a phosphodiesterase-III inhibitor, were observed…”
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Effects of Intracoronary Infusion of Escalating Doses of Cardiac Stem Cells in Rats With Acute Myocardial Infarction by Tang, Xian-Liang, Rokosh, Gregg, Sanganalmath, Santosh K, Tokita, Yukichi, Keith, Matthew C L, Shirk, Gregg, Stowers, Heather, Hunt, Gregory N, Wu, Wenjian, Dawn, Buddhadeb, Bolli, Roberto

“…Although c-kit(pos) cardiac stem cells (CSCs) preserve left ventricular (LV) function and structure after myocardial infarction, CSC doses have been chosen…”
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Long-Term Outcome of Administration of c-kitPOS Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year by Tang, Xian-Liang, Li, Qianhong, Rokosh, Gregg, Sanganalmath, Santosh K, Chen, Ning, Ou, Qinghui, Stowers, Heather, Hunt, Greg, Bolli, Roberto

“…RATIONALE:Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term…”
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Impact of Age on the Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia by Ginsberg, Henry N., Tuomilehto, Jaakko, Hovingh, G. Kees, Cariou, Bertrand, Santos, Raul D., Brown, Alan S., Sanganalmath, Santosh K., Koren, Andrew, Thompson, Desmond, Raal, Frederick J.

“…Purpose This post-hoc analysis examined whether age modified the efficacy and safety of alirocumab, a PCSK9 inhibitor, in patients with heterozygous familial…”
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Transplantation of expanded bone marrow‐derived very small embryonic‐like stem cells (VSEL‐SCs) improves left ventricular function and remodelling after myocardial infarction by Zuba‐Surma, Ewa K., Guo, Yiru, Taher, Hisham, Sanganalmath, Santosh K., Hunt, Greg, Vincent, Robert J., Kucia, Magda, Abdel‐Latif, Ahmed, Tang, Xian‐Liang, Ratajczak, Mariusz Z., Dawn, Buddhadeb, Bolli, Roberto

“…Adult bone marrow‐derived very small embryonic‐like stem cells (VSEL‐SCs) exhibit a Sca‐1+/Lin–/CD45– phenotype and can differentiate into various cell types,…”
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