Search Results - "Sanfridson, Annika"

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine by Deshmukh, Atul S, Peijs, Lone, Beaudry, Jacqueline L, Jespersen, Naja Z, Nielsen, Carsten H, Ma, Tao, Brunner, Andreas D, Larsen, Therese J, Bayarri-Olmos, Rafael, Prabhakar, Bhargav S, Helgstrand, Charlotte, Severinsen, Mai C K, Holst, Birgitte, Kjaer, Andreas, Tang-Christensen, Mads, Sanfridson, Annika, Garred, Peter, Privé, Gilbert G, Pedersen, Bente K, Gerhart-Hines, Zachary, Nielsen, Søren, Drucker, Daniel J, Mann, Matthias, Scheele, Camilla

“…Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and homeostasis, whereas the brown adipose secretome is less explored. We…”
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Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs by Christoffersen, Berit Ø., Skyggebjerg, Rikke Bjerring, Bugge, Anne, Kirk, Rikke Kaae, Vestergaard, Bill, Uldam, Henriette Kold, Fels, Johannes Josef, Pyke, Charles, Sensfuss, Ulrich, Sanfridson, Annika, Clausen, Trine Ryberg

“…Background/Objectives Cholecystokinin (CCK) is a regulator of appetite and energy intake in man. The aim of this study was to determine the effect of NN9056, a…”
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Nef Proteins Encoded by Human and Simian Immunodeficiency Viruses Induce the Accumulation of Endosomes and Lysosomes in Human T Cells by Sanfridson, Annika, Hester, Susan, Doyle, Carolyn

“…The nef gene of human and simian immunodeficiency viruses encodes a 27-32-kDa myristoylated protein that is expressed at high levels early after infection…”
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Safety, efficacy and biomarker data in patients with non-small cell lung cancer treated with the anti-IL1RAP antibody nadunolimab in combination with platinum doublet by Paz-Ares, Luis G., Paulus, Astrid, Zemaitis, Marius, Cicenas, Saulius, Zvirbule, Zanete, Felip, Enriqueta, Sanfridson, Annika, Rydberg-Millrud, Camilla, Magnusson, Susanne, Losic, Nedjad, Garcia-Ribas, Ignacio

“…9089 Background: Interleukin-1 Receptor Accessory Protein (IL1RAP), expressed in various tumors, is essential for IL-1α and IL-1β signaling. IL-1α/IL-1β are…”
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Efficacy and safety of the anti-IL1RAP antibody nadunolimab (CAN04) in combination with gemcitabine and nab-paclitaxel in patients with advanced/metastatic pancreatic cancer by Van Cutsem, Eric, Collignon, Joelle, Eefsen, Rikke L, Ochsenreither, Sebastian, Zvirbule, Zanete, Ivanauskas, Audrius, Arnold, Dirk, Baltruskeviciene, Edita, Pfeiffer, Per, Yachnin, Jeffrey, Magnusson, Susanne, Rydberg Millrud, Camilla, Sanfridson, Annika, Losic, Nedjad, Garcia-Ribas, Ignacio, Tersago, Dominique, Awada, Ahmad

“…Interleukin (IL)-1 pathway upregulation is implicated in pancreatic ductal adenocarcinoma (PDAC) progression, therapy resistance, and survival. Nadunolimab is…”
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145 Nadunolimab inhibits IL-1α/β-induced CXCR1/2 ligand expression and reduces serum levels of CXCL1 and CXCL5 in NSCLC and PDAC patients by Millrud, Camilla, Gyllenbäck, Elin, Skoog, Petter, Sanfridson, Annika, Liberg, David

“…BackgroundInterleukin-1 receptor accessory protein (IL1RAP) is expressed on tumor cells and stromal cells in most solid tumors, including PDAC and NSCLC…”
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Abstract C002: Interleukin-1 receptor accessory protein (IL1RAP) overexpression is associated with worse prognosis in PDAC and is targetable by nadunolimab by Van Cutsem, Eric, Abdilleh, Kawther, Datta, Jashodeep, Hidalgo, Manuel, Millrud, Camilla Rydberg, Skoog, Petter, Sanfridson, Annika, Tersago, Dominique, Liberg, David

“…Abstract Introduction: The pancreatic tumor microenvironment (TME) is a major driver of tumor progression, chemoresistance and immune suppression, and the IL-1…”
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TAB1 modulates IL-1α mediated cytokine secretion but is dispensable for TAK1 activation by Bertelsen, Malene, Sanfridson, Annika

“…Biochemical evidence indicates that TGF-β-activated kinase 1 (TAK1), a key modulator of the inflammatory response, exists in a complex with various adaptor…”
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Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets by Enoksson, Mari, Martin, Erika J., Holmberg, Heidi, Jensen, Mette S., Kjelgaard‐Hansen, Mads, Egebjerg, Thomas, Buchardt, Jens, Krogh, Thomas N., Demuth, Helle, Sanfridson, Annika, Hilden, Ida, Kjalke, Marianne, Brophy, Donald F.

“…Background Recombinant factor VIIa (rFVIIa) enhances thrombin generation in a platelet‐dependent manner; however, rFVIIa binds activated platelets with…”
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Abstract 2172: Tumor IL1RAP levels and reduction in serum biomarkers correlate with response in PDAC patients treated with nadunolimab, an anti-IL1RAP monoclonal antibody, in combination with gemcitabine and nab-paclitaxel by Van Cutsem, Eric, Collignon, Joelle, Eefsen, Rikke, Ochsenreither, Sebastian, Zvirbule, Zanete, Ivanauskas, Audrius, Millrud, Camilla Rydberg, Skoog, Petter, Losic, Nedjad, Magnusson, Susanne, Sanfridson, Annika, Liberg, David

“…Abstract Background: Interleukin-1 Receptor Accessory Protein (IL1RAP) is expressed on cancer and stromal cells in pancreatic ductal adenocarcinoma (PDAC), and…”
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TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation by Bertelsen, Malene, Sanfridson, Annika

“…Biochemical evidence indicates that TGF-beta-activated kinase 1 (TAK1), a key modulator of the inflammatory response, exists in a complex with various adaptor…”
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Inflammatory pathway analysis using a high content screening platform by Bertelsen, Malene, Sanfridson, Annika

“…High content cellular screening assays are useful tools to investigate the interplay between signaling pathways and offer valuable platforms to determine the…”
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Signal-transduction cascades as targets for therapeutic intervention by natural products by Cardenas, Maria Elena, Sanfridson, Annika, Cutler, N.Shane, Heitman, Joseph

“…Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies…”
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Downregulation of cell-surface CD4 expression by Simian immunodeficiency virus nef prevents viral super infection by BENSON, R. E, SANFRIDSON, A, OTTINGER, J. S, DOYLE, C, CULLEN, B. R

“…The nef gene product encoded by the mac239 proviral clone of simian immunodeficiency virus (SIV) markedly enhances viral replication and pathogenesis in vivo…”
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Effects of the SIV(mac239) NEF protein in human CD4(+) T lymphocytes by Sanfridson, Annika

“…The CD4 co-receptor functions as a signalling molecule important for the activation of T helper cells and is the viral receptor for the human and simian…”
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Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins by HENICS, T, SANFRIDSON, A, HAMILTON, B. J, NAGY, E, RIGBY, W. F. C

“…The MLA 144 gibbon T cell line is infected with a type C retrovirus and constitutively expresses interleukin-2 (IL-2) and granulocyte macrophage…”
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The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells by SANFRIDSON, A, CULLEN, B. R, DOYLE, C

“…Expression of the Nef protein encoded by human and simian immunodeficiency viruses results in the specific down-regulation of CD4 from the cell surface in both…”
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Effects of the SIV(mac239) NEF protein in human CD4(+) T lymphocytes by Sanfridson, Annika

“…The CD4 co-receptor functions as a signalling molecule important for the activation of T helper cells and is the viral receptor for the human and simian…”
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