Are adverse pregnancy outcomes risk factors for development of end-stage renal disease in women with diabetes?

Background. It is unknown whether adverse pregnancy-related outcomes in women with pregestational diabetes are associated with later development of end-stage renal disease (ESRD) or death. Methods. We linked data from the Medical Birth Registry of Norway with data from the Norwegian Renal Registry a...

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Bibliographic Details
Published in:	Nephrology, dialysis, transplantation Vol. 25; no. 11; pp. 3600 - 3607
Main Authors:	Sandvik, Miriam K., Iversen, Bjarne M., Irgens, Lorentz M., Skjaerven, Rolv, Leivestad, Torbjørn, Søfteland, Eirik, Vikse, Bjørn Egil
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-11-2010
Subjects:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences diabetes Diabetic Nephropathies - etiology Diabetic Nephropathies - mortality Emergency and intensive care: renal failure. Dialysis management endothelial dysfunction Endothelium, Vascular - physiology ESRD Female Follow-Up Studies Humans Intensive care medicine Kidney Failure, Chronic - etiology Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pre-Eclampsia Pregnancy Pregnancy in Diabetics Premature Birth Renal failure Risk Factors Human Kidney disease ESRD Urinary system disease Prognosis Pregnancy disorders Hemodialysis Terminal stage pre-eclampsia endothelial dysfunction Pregnancy toxemia Pregnancy Extrarenal dialysis Eclampsia Risk factor Renal failure diabetes
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Summary:	Background. It is unknown whether adverse pregnancy-related outcomes in women with pregestational diabetes are associated with later development of end-stage renal disease (ESRD) or death. Methods. We linked data from the Medical Birth Registry of Norway with data from the Norwegian Renal Registry and the Norwegian Cause of Death Registry. Data from up to three pregnancies for women with a first singleton delivery from 1967 to 1994 were included and analysed in a cohort design using Cox regression. Results. Altogether, 639 018 women were included in the analyses, among whom 2204 women had diabetes mellitus before pregnancy. Their first pregnancy was complicated by pre-eclampsia in 13.2%, low birth weight offspring (<2.5 kg) in 11.0% and preterm birth in 25.1%, and their risk of ESRD and death in the follow-up period of up to 37 years was markedly higher. In women with pregestational diabetes, pre-eclampsia and preterm birth were associated with significantly increased risks of ESRD and death in women with only one pregnancy, but not in women with two or more pregnancies. Conclusions. In women with pregestational diabetes, pre-eclampsia and preterm birth were associated with long-term increased risk of ESRD and death, but only in women who had only one pregnancy.
Bibliography:	ark:/67375/HXZ-M1LBKN5M-Z istex:13F58C0EC32EEFD20AF175084A3CDE33F87B3B76 ArticleID:gfq275 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0931-0509 1460-2385
DOI:	10.1093/ndt/gfq275