Search Results - "Sandrock, Alfred W."

A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis by Polman, Chris H, O'Connor, Paul W, Havrdova, Eva, Hutchinson, Michael, Kappos, Ludwig, Miller, David H, Phillips, J. Theodore, Lublin, Fred D, Giovannoni, Gavin, Wajgt, Andrzej, Toal, Martin, Lynn, Frances, Panzara, Michael A, Sandrock, Alfred W

“…This placebo-controlled, randomized trial of patients with relapsing multiple sclerosis demonstrated benefits of natalizumab (an α 4 integrin antagonist) in…”
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Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study by Kappos, Ludwig, Prof, Gold, Ralf, Prof, Miller, David H, Prof, MacManus, David G, MSc, Havrdova, Eva, MD, Limmroth, Volker, MD, Polman, Chris H, Prof, Schmierer, Klaus, PhD, Yousry, Tarek A, MD, Yang, Minhua, MS, Eraksoy, Mefkûre, Prof, Meluzinova, Eva, MD, Rektor, Ivan, MD, Dawson, Katherine T, MD, Sandrock, Alfred W, MD, O'Neill, Gilmore N, MB

“…Summary Background Oral fumarate (BG00012) might have dual anti-inflammatory and neuroprotective effects. Our aim was to assess the efficacy and safety of…”
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Assessment of JC virus DNA in blood and urine from natalizumab-treated patients by Rudick, Richard A., O'Connor, Paul W., Polman, Chris H., Goodman, Andrew D., Ray, Soma S., Griffith, Nancy M., Jurgensen, Stephanie A., Gorelik, Leonid, Forrestal, Fiona, Sandrock, Alfred W., E. Goelz, Susan

“…Objective Analyses were conducted to determine the clinical utility of measuring JC virus (JCV) DNA in blood or urine of natalizumab‐treated multiple sclerosis…”
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Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis by Jacobs, Lawrence D, Beck, Roy W, Simon, Jack H, Kinkel, R. Phillip, Brownscheidle, Carol M, Murray, Thomas J, Simonian, Nancy A, Slasor, Peter J, Sandrock, Alfred W

“…Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically…”
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LINGO-1 antagonists as therapy for multiple sclerosis: in vitro and in vivo evidence by Rudick, Richard A, Mi, Sha, Sandrock, Jr, Alfred W

“…Multiple sclerosis (MS) is an inflammatory disease of the CNS that causes progressive neurological disability in most patients. Certain alleles of…”
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COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies by Reder, Anthony T., Centonze, Diego, Naylor, Maria L., Nagpal, Anjali, Rajbhandari, Rajani, Altincatal, Arman, Kim, Michelle, Berdofe, Aaron, Radhakrishnan, Maha, Jung, Eunice, Sandrock, Alfred W., Smirnakis, Karen, Popescu, Catrinel, de Moor, Carl

“…Background Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase the risk of severe acute…”
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Comparisons Between Separately Conducted Clinical Trials: Letter to the Editor Regarding Dabbous O, Maru B, Jansen JP, Lorenzi M, Cloutier M, Guérin A, et al. Adv Ther (2019) 36(5):1164–76. doi:10.1007/s12325-019-00923-8 by Sandrock, Alfred W., Farwell, Wildon

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Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo by Sandrock, Alfred W., Dryer, Stuart E., Rosen, Kenneth M., Gozani, Shai N., Kramer, Rainer, Theill, Lars E., Fischbach, Gerald D.

“…ARIA (for acetylcholine receptor-inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in…”
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Association of Serum Neurofilament Light Levels With Long-term Brain Atrophy in Patients With a First Multiple Sclerosis Episode by Plavina, Tatiana, Singh, Carol M, Sangurdekar, Dipen, de Moor, Carl, Engle, Bob, Gafson, Arie, Goyal, Jaya, Fisher, Elizabeth, Szak, Suzanne, Kinkel, Revere P, Sandrock, Alfred W, Su, Ray, Kieseier, Bernd C, Rudick, Richard A

“…Data are needed on the potential long-term prognostic association of serum neurofilament light in multiple sclerosis (MS). To evaluate serum neurofilament…”
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Heterogeneity of Subcellular Localization and Electrophoretic Mobility of Survival Motor Neuron (SMN) Protein in Mammalian Neural Cells and Tissues by Francis, Jonathan W., Sandrock, Alfred W., Bhide, Pradeep G., Vonsattel, Jean-Paul, Brown, Robert H.

“…Spinal muscular atrophy is caused by defects in the survival motor neuron (SMN) gene. To better understand the patterns of expression of SMN in neuronal cells…”
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Natalizumab and central nervous system lymphoma: No clear association by Bozic, Carmen, LaGuette, Julia, Panzara, Michael A., Sandrock, Alfred W.

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More on Melanoma with Transdifferentiation by Panzara, Michael A, Bozic, Carmen, Sandrock, Alfred W

“…To the Editor: Mullen et al. (Feb. 7 issue) 1 report on two cases of melanoma in patients with multiple sclerosis who received natalizumab. Their letter shows…”
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Asymptomatic Reactivation of JC Virus in Patients Treated with Natalizumab by Gorelik, Leonid, Goelz, Susan, Sandrock, Alfred W

“…To the Editor: Chen and colleagues (Sept. 10 issue) 1 describe an increased prevalence of JC virus DNA in 19 patients with multiple sclerosis after 12 to 18…”
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Interferon β-1a for early multiple sclerosis: CHAMPS trial subgroup analyses by Beck, Roy W., Chandler, Danielle L., Cole, Stephen R., Simon, Jack H., Jacobs, Lawrence D., Kinkel, R. Philip, Selhorst, John B., Rose, John W., Cooper, Joanna A., Rice, George, Murray, Thomas J., Sandrock, Alfred W.

“…The objective of this work was to assess the effect of interferon β‐1a (Avonex®) on the rate of development of clinically definite multiple sclerosis and brain…”
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An in Vitro Neurite-Promoting Antigen Functions in Axonal Regeneration in vivo by Sandrock, Alfred W., Matthew, William D.

“…The function of the neurite growth-promoting antigen INO has been tested in an in vivo neurite regeneration system, the rat iris. The sympathetic innervation…”
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Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study by De Vivo, Darryl C., Bertini, Enrico, Swoboda, Kathryn J., Hwu, Wuh-Liang, Crawford, Thomas O., Finkel, Richard S., Kirschner, Janbernd, Kuntz, Nancy L., Parsons, Julie A., Ryan, Monique M., Butterfield, Russell J., Topaloglu, Haluk, Ben-Omran, Tawfeg, Sansone, Valeria A., Jong, Yuh-Jyh, Shu, Francy, Staropoli, John F., Kerr, Douglas, Sandrock, Alfred W., Stebbins, Christopher, Petrillo, Marco, Braley, Gabriel, Johnson, Kristina, Foster, Richard, Gheuens, Sarah, Bhan, Ishir, Reyna, Sandra P., Fradette, Stephanie, Farwell, Wildon

“…•NURTURE is an ongoing study of nusinersen started in a presymptomatic stage of SMA.•All infants were ≥25 months old, and alive without permanent…”
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ARIA Is Concentrated in the Synaptic Basal Lamina of the Developing Chick Neuromuscular Junction by Andrew D. J. Goodearl, Yee, Ann G., Sandrock, Alfred W., Corfas, Gabriel, Fischbach, Gerald D.

“…ARIA is a member of a family of polypeptide growth and differentiation factors that also includes glial growth factor (GGF), neu differentiation factor, and…”
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Noninvasive detection of fibrillation potentials in skeletal muscle by Keller, S.P., Sandrock, A.W., Gozani, S.N.

“…The presence of spontaneous muscle activity was determined by analysis of the power spectra of computer-model-generated sequences of spontaneous activity and…”
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Natalizumab plus Interferon Beta-1a for Relapsing Multiple Sclerosis by Rudick, Richard A, Stuart, William H, Calabresi, Peter A, Confavreux, Christian, Galetta, Steven L, Radue, Ernst-Wilhelm, Lublin, Fred D, Weinstock-Guttman, Bianca, Wynn, Daniel R, Lynn, Frances, Panzara, Michael A, Sandrock, Alfred W

“…In this randomized trial involving patients with relapsing multiple sclerosis who had had relapses despite treatment with interferon, natalizumab in…”
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Case 11-1997: A 51-year-old Man with Chronic Obstructive Pulmonary Disease and Generalized Muscle Weakness by Sandrock, Alfred W, Cros, Didier P, Louis, David N

“…Presentation of Case A 51-year-old man was admitted to the hospital with respiratory failure. He was known to have had chronic obstructive pulmonary disease…”
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