Search Results - "Sandro M. Hirabara"

Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice by Li, Xiruo, Zhang, Dongyan, Vatner, Daniel F., Goedeke, Leigh, Hirabara, Sandro M., Zhang, Ye, Perry, Rachel J., Shulman, Gerald I.

“…Adiponectin has emerged as a potential therapy for type 2 diabetes mellitus, but the molecular mechanism by which adiponectin reverses insulin resistance…”
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SARS-COV-2 Variants: Differences and Potential of Immune Evasion by Hirabara, Sandro M, Serdan, Tamires D A, Gorjao, Renata, Masi, Laureane N, Pithon-Curi, Tania C, Covas, Dimas T, Curi, Rui, Durigon, Edison L

“…The structural spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) plays an essential role in infection and is an important…”
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Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function by Martins, Amanda R, Nachbar, Renato T, Gorjao, Renata, Vinolo, Marco A, Festuccia, William T, Lambertucci, Rafael H, Cury-Boaventura, Maria F, Silveira, Leonardo R, Curi, Rui, Hirabara, Sandro M

“…Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although…”
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Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance by TSUKUMO, Daniela M. L, CARVALHO-FILHO, Marco A, SAAD, Mario J. A, CARVALHEIRA, José B. C, PRADA, Patricia O, HIRABARA, Sandro M, SCHENKA, André A, ARAUJO, Eliana P, VASSALLO, José, CURI, Rui, VELLOSO, Licio A

“…Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance Daniela M.L. Tsukumo 1 , Marco A. Carvalho-Filho 1 ,…”
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Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice by Vinolo, Marco Aurélio Ramirez, Rodrigues, Hosana G, Festuccia, William T, Crisma, Amanda R, Alves, Vitor S, Martins, Amanda R, Amaral, Catia L, Fiamoncini, Jarlei, Hirabara, Sandro M, Sato, Fabio T, Fock, Ricardo A, Malheiros, Gabriella, dos Santos, Marinilce F, Curi, Rui

“…The aim of this study was to investigate whether treatment with tributyrin (Tb; a butyrate prodrug) results in protection against diet-induced obesity and…”
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Essential metabolism required for T and B lymphocyte functions: an update by Diniz, Vinicius Leonardo Sousa, Alvares-Saraiva, Anuska Marcelino, Serdan, Tamires Duarte Afonso, Dos Santos-Oliveira, Laiane Cristina, Cruzat, Vinicius, Lobato, Tiago Bertola, Manoel, Richelieau, Alecrim, Amanda Lins, Machado, Otavio Augusto, Hirabara, Sandro M, Masi, Laureane Nunes, Pithon-Curi, Tania Cristina, Curi, Rui, Gorjão, Renata, Newsholme, Philip

“…Lymphocytes act as regulatory and effector cells in inflammation and infection situations. A metabolic switch towards glycolytic metabolism predominance occurs…”
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Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions by Hirabara, Sandro Massao, Gorjão, Renata, Vinolo, Marco Aurélio Ramirez, Rodrigues, Alice C., Nachbar, Renato T., Curi, Rui

“…Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, and…”
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Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes by Anhê, Gabriel F., Okamoto, Maristela M., Kinote, Andrezza, Sollon, Carolina, Lellis-Santos, Camilo, Anhê, Fernando F., Lima, Guilherme A., Hirabara, Sandro M., Velloso, Licio A., Bordin, Silvana, Machado, Ubiratan F.

“…Quercetin is a potent anti-inflammatory flavonoid, but its capacity to modulate insulin sensitivity in obese insulin resistant conditions is unknown. This…”
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Epidemiology of COVID-19 in Brazil: using a mathematical model to estimate the outbreak peak and temporal evolution by Tang, Yuanji, Serdan, Tamires D. A., Masi, Laureane N., Tang, Sherry, Gorjao, Renata, Hirabara, Sandro M.

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Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα by Souza, Camila O., Teixeira, Alexandre A. S., Lima, Edson A., Batatinha, Helena A. P., Gomes, Lara M., Carvalho-Silva, Milena, Mota, Isabella T., Streck, Emilio L., Hirabara, Sandro M., Neto, José C. Rosa

“…Palmitoleic acid (PMA) has anti-inflammatory and antidiabetic activities. Here we tested whether these effects of PMA on glucose homeostasis and liver…”
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Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats by Lambertucci, Adriana C, Lambertucci, Rafael H, Hirabara, Sandro M, Curi, Rui, Moriscot, Anselmo S, Alba-Loureiro, Tatiana C, Guimarães-Ferreira, Lucas, Levada-Pires, Adriana C, Vasconcelos, Diogo A A, Sellitti, Donald F, Pithon-Curi, Tania C

“…In this study, we investigated the effect of glutamine (Gln) supplementation on the signaling pathways regulating protein synthesis and protein degradation in…”
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Updating the effects of fatty acids on skeletal muscle by Silveira, Leonardo R., Fiamoncini, Jarlei, Hirabara, Sandro M., Procópio, Joaquim, Cambiaghi, Tavane D., Pinheiro, Carlos Hermano J., Lopes, Lúcia R., Curi, Rui

“…In this review we updated the fatty acid (FA) effects on skeletal muscle metabolism. Abnormal FA availability induces insulin resistance and accounts for…”
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Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells by Hirabara, Sandro M., Curi, Rui, Maechler, Pierre

“…Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as obesity and type 2 diabetes mellitus. These high levels of…”
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Fish oil supplementation for two generations increases insulin sensitivity in rats by Hirabara, Sandro M, Folador, Alessandra, Fiamoncini, Jarlei, Lambertucci, Rafael H, Rodrigues, Carlos F. Jr, Rocha, Marlene S, Aikawa, Julia, Yamazaki, Ricardo K, Martins, Amanda R, Rodrigues, Alice C, Carpinelli, Angelo R, Pithon-Curi, Tania C, Fernandes, Luiz C, Gorjão, Renata, Curi, Rui

“…We investigated the effect of fish oil supplementation for two consecutive generations on insulin sensitivity in rats. After the nursing period (21 days),…”
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Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice by Sousa, Luis Gustavo O. de, Hirabara, Sandro Massao, Neto, José César Rosa, Moreira, Renata G., Santamarina, Aline Boveto, Souza, Gabriel I. H., Davanso, Mariana R., Crisma, Amanda R., Masi, Laureane Nunes, Silveira, Loreana S., de Lima Júnior, Edson Alves, Martins, Amanda Roque

“…Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and…”
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Time-dependent effects of fatty acids on skeletal muscle metabolism by Hirabara, Sandro M., Silveira, Leornardo R., Abdulkader, Fernando, Carvalho, Carla R.O., Procopio, Joaquim, Curi, Rui

“…Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as type 2 diabetes mellitus, obesity, and metabolic syndrome…”
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Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation by Luchessi, Augusto D., Cambiaghi, Tavane D., Hirabara, Sandro M., Lambertucci, Rafael H., Silveira, Leonardo R., Baptista, Igor L., Moriscot, Anselmo S., Costa-Neto, Claudio M., Curi, Rui

“…The eukaryotic translation initiation factor 5A (eIF5A) contains a special amino acid residue named hypusine that is required for its activity, being produced…”
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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance by Lyu, Kun, Zhang, Ye, Zhang, Dongyan, Kahn, Mario, ter Horst, Kasper W., Rodrigues, Marcos R.S., Gaspar, Rafael C., Hirabara, Sandro M., Luukkonen, Panu K., Lee, Seohyuk, Bhanot, Sanjay, Rinehart, Jesse, Blume, Niels, Rasch, Morten Grønbech, Serlie, Mireille J., Bogan, Jonathan S., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.

“…Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance (HIR); however, the key lipid species and molecular mechanisms linking…”
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The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle by Kaspari, Rachel R., Reyna-Neyra, Andrea, Jung, Lara, Torres-Manzo, Alejandra Paola, Hirabara, Sandro M., Carrasco, Nancy

“…Obesity is a major health problem worldwide, given its growing incidence and its association with a variety of comorbidities. Weight gain results from an…”
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Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet by Martins, Amanda R., Crisma, Amanda R., Masi, Laureane N., Amaral, Catia L., Marzuca-Nassr, Gabriel N., Bomfim, Lucas H.M., Teodoro, Bruno G., Queiroz, André L., Serdan, Tamires D.A., Torres, Rosangela P., Mancini-Filho, Jorge, Rodrigues, Alice C., Alba-Loureiro, Tatiana C., Pithon-Curi, Tania C., Gorjao, Renata, Silveira, Leonardo R., Curi, Rui, Newsholme, Philip, Hirabara, Sandro M.

“…Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin sensitivity and glucose homeostasis in animal models of insulin…”
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