Search Results - "Sandra J Hewett"

The Cystine/Glutamate Antiporter, System xc–, Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice by He, Yan, Hewett, Sandra J.

“…Understanding the mechanisms underlying ischemic brain injury is of importance to the goal of devising novel therapeutics for protection and/or recovery…”
Get full text

Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system xc by Sears, Sheila M. S., Roberts, Sarah H., Hewett, Sandra J.

“…System xc− (Sxc−) is a heteromeric antiporter (L‐cystine/L‐glutamate exchanger) expressed predominately on astrocytes in the central nervous system. Its…”
Get full text

Sex- and age-dependent contribution of System xc– to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System xc– null mice by Frare, Carla, Pitt, Shannon K., Hewett, Sandra J.

“…Background: System xc − (Sxc − ) is an important heteromeric amino acid cystine/glutamate exchanger that plays a pivotal role in the CNS by importing cystine…”
Get full text

P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in maintenance of the innate seizure threshold by Dutta, Spandita S., Andonova, Antoaneta A., Wöellert, Torsten, Hewett, Sandra J., Hewett, James A.

“…Disruption of Interleukin-1β (IL-1β) signaling sensitized mice to convulsant stimuli, suggesting that this quintessential cytokine of the innate immune system…”
Get full text

Editorial: The known, the unknown, and the future of glutamate transporters by Martinez-Lozada, Zila, Hewett, Sandra J., Zafra, Francisco, Ortega, Arturo

“…[...]maintenance of the glutamate extracellular concentration involves tight control of its release and uptake. [...]the cystine/glutamate exchanger, also…”
Get full text

Sexually dimorphic and brain region-specific transporter adaptations in system xc− null mice by Sosnoski, Heather M., Sears, Sheila M.S., He, Yan, Frare, Carla, Hewett, Sandra J.

“…System xc− is a heterodimeric amino acid antiporter that, in the central nervous system, is best known for linking the import of L-cystine (CySS) with the…”
Get full text

Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination by Evonuk, Kirsten S, Baker, Brandi J, Doyle, Ryan E, Moseley, Carson E, Sestero, Christine M, Johnston, Bryce P, De Sarno, Patrizia, Tang, Andrew, Gembitsky, Igor, Hewett, Sandra J, Weaver, Casey T, Raman, Chander, DeSilva, Tara M

“…T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune inflammatory demyelinating diseases. Several lines of evidence suggest…”
Get full text

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ‐induced seizure generation and kindling acquisition by Claycomb, Robert J., Hewett, Sandra J., Hewett, James A.

“…Summary Purpose:  The goal of this study was to determine whether prophylactic prandial administration of rofecoxib, a selective cyclooxygenase‐2 (COX‐2)…”
Get full text

Neuromodulatory role of endogenous interleukin-1β in acute seizures: Possible contribution of cyclooxygenase-2 by Claycomb, Robert J, Hewett, Sandra J, Hewett, James A

“…Abstract The function of endogenous interleukin-1β (IL-1β) signaling in acute seizure activity was examined using transgenic mice harboring targeted deletions…”
Get full text

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance by Sears, Sheila MS, Hewett, Sandra J

“…An optimally functional brain requires both excitatory and inhibitory inputs that are regulated and balanced. A perturbation in the excitatory/inhibitory…”
Get full text

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system by Hewett, Sandra J, Bell, Stanley C, Hewett, James A

“…Cyclooxygenase (COX) enzymes, or prostaglandin-endoperoxide synthases (PTGS), are heme-containing bis-oxygenases that catalyze the first committed reaction in…”
Get full text

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production by Chowdhury, Twinkle, Allen, Matthew F, Thorn, Trista L, He, Yan, Hewett, Sandra J

“…Interleukin-1β (IL-1β), a key cytokine that drives neuroinflammation in the Central Nervous System (CNS), is enhanced in many neurological diseases/disorders…”
Get full text

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression by Hamby, Mary E., Hewett, James A., Hewett, Sandra J.

“…We previously demonstrated that transforming growth factor‐β1 (TGF‐β1), while having no effect alone, enhances nitric oxide (NO) production in primary,…”
Get full text

Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes by Hamby, Mary E., Uliasz, Tracy F., Hewett, Sandra J., Hewett, James A.

“…Cultures of astrocytes can be readily established and are widely used to study the biological functions of these glial cells in isolation. Unfortunately,…”
Get full text

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities by Lewerenz, Jan, Hewett, Sandra J, Huang, Ying, Lambros, Maria, Gout, Peter W, Kalivas, Peter W, Massie, Ann, Smolders, Ilse, Methner, Axel, Pergande, Mathias, Smith, Sylvia B, Ganapathy, Vadivel, Maher, Pamela

“…The antiporter system x(c)(-) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is…”
Get more information

Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration by Hewett, Sandra J, Silakova, Janna M, Hewett, James A

“…The purpose of this study was to determine whether the selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib…”
Get more information

Interleukin-1β: a bridge between inflammation and excitotoxicity by Fogal, Birgit, Hewett, Sandra J

“…Interleukin-1 (IL-1) is a proinflammatory cytokine released by many cell types that acts in both an autocrine and/or paracrine fashion. While IL-1 is best…”
Get full text

Non-cell autonomous influence of the astrocyte system xc- on hypoglycaemic neuronal cell death by Jackman, Nicole A, Melchior, Shannon E, Hewett, James A, Hewett, Sandra J

“…Despite longstanding evidence that hypoglycaemic neuronal injury is mediated by glutamate excitotoxicity, the cellular and molecular mechanisms involved remain…”
Get full text

Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties by Sen, Ellora, Basu, Anirban, Willing, Lisa B, Uliasz, Tracy F, Myrkalo, Jaimie L, Vannucci, Susan J, Hewett, Sandra J, Levison, Steven W

“…Hypoxic preconditioning reprogrammes the brain's response to subsequent H/I (hypoxia-ischaemia) injury by enhancing neuroprotective mechanisms. Given that…”
Get full text

Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system x c by Sears, Sheila M S, Roberts, Sarah H, Hewett, Sandra J

“…System x (Sx ) is a heteromeric antiporter (L-cystine/L-glutamate exchanger) expressed predominately on astrocytes in the central nervous system. Its activity…”
Get full text