Search Results - "Sandoval, Maria Regina Lopes"

β-micrustoxin (Mlx-9), a PLA2 from Micrurus lemniscatus snake venom: biochemical characterization and anti-proliferative effect mediated by p53 by Santos, Natália Fernanda Teixeira dos, Imberg, Andréia de Souza, Mariano, Douglas Oscar Ceolin, Moraes, Angelina Cirelli de, Andrade-Silva, Jessica, Fernandes, Cristina Maria, Sobral, Ana Cláudia, Giannotti, Karina Cristina, Kuwabara, Wilson M. Tatagiba, Pimenta, Daniel Carvalho, Maria, Durvanei Augusto, Sandoval, Maria Regina Lopes, Afeche, Solange Castro

“…BackgroundEndogenous phospholipases A2 (PLA2) play a fundamental role in inflammation, neurodegenerative diseases, apoptosis and cellular senescence…”
Get full text

Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus by Santos, Roberta Tancredi Francesco dos, Silva, Marcelo Florencio Passos, Porto, Rafael Marques, Lebrun, Ivo, Gonçalves, Luís Roberto de Camargo, Batista, Isabel de Fátima Correia, Sandoval, Maria Regina Lopes, Abdalla, Fernando Maurício Francis

“…Abstract Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with…”
Get full text

Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture by Garcia, Raphael Caio Tamborelli, Torres, Larissa Lobo, Dati, Livia Mendonça Munhoz, Loureiro, Ana Paula de Melo, Afeche, Solange Castro, Sandoval, Maria Regina Lopes, Marcourakis, Tania

“…•AEME and cocaine decreased GPx, GR and GST activities after 3 and 6 h of exposure.•AEME and cocaine increased MDA after 48 h of exposure.•AEME-cocaine…”
Get full text

TsTx Toxin Isolated from Tityus serrulatus Scorpion Venom Induces Spontaneous Recurrent Seizures and Mossy Fiber Sprouting by Regina, Maria, Sandoval, Lopes, Lebrun, Ivo

“…Purpose: To characterize the long‐term behavioral, electroencephalographic (EEG) and histopathologic features after a single TsTx microinjection into the…”
Get full text

Anhydroecgonine methyl ester, a cocaine pyrolysis product, may contribute to cocaine behavioral sensitization by Garcia, Raphael Caio Tamborelli, Torres, Larissa Helena, Balestrin, Natália Trigo, Andrioli, Tatiana Costa, Flório, Jorge Camilo, Oliveira, Carolina Dizioli Rodrigues de, Costa, José Luiz da, Yonamine, Mauricio, Sandoval, Maria Regina Lopes, Camarini, Rosana, Marcourakis, Tania

“…Abstract Crack cocaine has a high potential to induce cocaine addiction and its smoke contains cocaine’s pyrolysis product anhydroecgonine methyl ester (AEME),…”
Get full text

Neurotoxicity of coral snake phospholipases A2 in cultured rat hippocampal neurons by de Carvalho, Nathalia Delazeri, Garcia, Raphael CaioTamborelli, Kleber Ferreira, Adilson, Rodrigo Batista, Daniel, Carlos Cassola, Antonio, Maria, Durvanei, Lebrun, Ivo, Mendes Carneiro, Sylvia, Castro Afeche, Solange, Marcourakis, Tania, Sandoval, Maria Regina Lopes

“…Abstract The neurotoxicity of two secreted Phospholipases A2 from Brazilian coral snake venom in rat primary hippocampal cell culture was investigated…”
Get full text

Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease by Guardia de Souza e Silva, Tiago, do Val de Paulo, Maria Eliza Ferreira, da Silva, Jeferson Rubens Mamona, da Silva Alves, Adilson, Britto, Luiz Roberto G., Xavier, Gilberto Fernando, Lopes Sandoval, Maria Regina

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of…”
Get full text

Neurotoxicity of anhydroecgonine methyl ester, a crack cocaine pyrolysis product by Garcia, Raphael Caio Tamborelli, Dati, Livia Mendonça Munhoz, Fukuda, Suelen, Torres, Larissa Helena Lobo, Moura, Sidnei, de Carvalho, Nathalia Delazeri, Carrettiero, Daniel Carneiro, Camarini, Rosana, Levada-Pires, Adriana Cristina, Yonamine, Mauricio, Negrini-Neto, Osvaldo, Abdalla, Fernando Maurício Francis, Sandoval, Maria Regina Lopes, Afeche, Solange Castro, Marcourakis, Tania

“…Smoking crack cocaine involves the inhalation of cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). Although there is evidence that…”
Get full text

M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product by Garcia, Raphael Caio Tamborelli, Dati, Livia Mendonça Munhoz, Torres, Larissa Helena, da Silva, Mariana Aguilera Alencar, Udo, Mariana Sayuri Berto, Abdalla, Fernando Maurício Francis, da Costa, José Luiz, Gorjão, Renata, Afeche, Solange Castro, Yonamine, Mauricio, Niswender, Colleen M., Conn, P. Jeffrey, Camarini, Rosana, Sandoval, Maria Regina Lopes, Marcourakis, Tania

“…The smoke of crack cocaine contains cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). AEME possesses greater neurotoxic potential than…”
Get full text

Characterization of a new muscarinic toxin from the venom of the Brazilian coral snake Micrurus lemniscatus in rat hippocampus by da Silva, Daniel Coelho, de Medeiros, Wyara Aparecida Araújo, Batista, Isabel de Fátima Correia, Pimenta, Daniel Carvalho, Lebrun, Ivo, Abdalla, Fernando Maurício Francis, Sandoval, Maria Regina Lopes

“…We have isolated a new muscarinic protein (MT-Mlα) from the venom of the Brazilian coral snake Micrurus lemniscatus. This small protein, which had a molecular…”
Get full text

Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy by Luongo, Roberta, Oliveira, Diana Amaral, Lebrun, Ivo, Sandoval, Maria Regina Lopes

“…Abstract We have characterized earlier the long-term behavioural, electroencephalographic and histopatologic features after a single TsTx microinjection,…”
Get full text

TSII toxin isolated from Tityus serrulatus scorpion venom: behavioral, electroencephalographic, and histopathologic studies by Sandoval, Maria Regina Lopes, Lebrun, Ivo

“…We have reported earlier that intrahippocampal administration of the C-pool from Tityus serrulatus scorpion venom induces convulsions in rats. Here we report…”
Get full text

The M 1 -muscarinic acetylcholine receptor subtype may play a role in learning and memory performance in the hippocampus of neonatal monosodium glutamate-obese rats by Silva, Marcelo Florencio Passos, Rafael, Christian Pereira, Mamona Silva, Jeferson Rubens, e Silva, Tiago Guardia de Souza, Alponti, Rafaela Fadoni, Alves, Patricia Lucio, Sandoval, Maria Regina Lopes, Abdalla, Fernando Maurício Francis

“…Here, we investigate the effects of obesity induced by monosodium glutamate (MSG) on cognitive impairment and whether this model induces any alteration in the…”
Get full text

The M1-muscarinic acetylcholine receptor subtype may play a role in learning and memory performance in the hippocampus of neonatal monosodium glutamate-obese rats by Silva, Marcelo Florencio Passos, Rafael, Christian Pereira, Mamona Silva, Jeferson Rubens, e Silva, Tiago Guardia de Souza, Alponti, Rafaela Fadoni, Alves, Patricia Lucio, Sandoval, Maria Regina Lopes, Abdalla, Fernando Maurício Francis

“…Here, we investigate the effects of obesity induced by monosodium glutamate (MSG) on cognitive impairment and whether this model induces any alteration in the…”
Get full text

β-micrustoxin (Mlx-9), a PLA 2 from Micrurus lemniscatus snake venom: biochemical characterization and anti-proliferative effect mediated by p53 by Dos Santos, Natália Fernanda Teixeira, Imberg, Andréia de Souza, Mariano, Douglas Oscar Ceolin, de Moraes, Angelina Cirelli, Andrade-Silva, Jessica, Fernandes, Cristina Maria, Sobral, Ana Cláudia, Giannotti, Karina Cristina, Kuwabara, Wilson M Tatagiba, Pimenta, Daniel Carvalho, Maria, Durvanei Augusto, Sandoval, Maria Regina Lopes, Afeche, Solange Castro

“…Endogenous phospholipases A (PLA ) play a fundamental role in inflammation, neurodegenerative diseases, apoptosis and cellular senescence. Neurotoxins with PLA…”
Get full text

Effects of Mlx-8, a phospholipase A 2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus by Dos Santos, Roberta Tancredi Francesco, Silva, Marcelo Florencio Passos, Porto, Rafael Marques, Lebrun, Ivo, Gonçalves, Luís Roberto de Camargo, Batista, Isabel de Fátima Correia, Sandoval, Maria Regina Lopes, Abdalla, Fernando Maurício Francis

“…Here, we described the presence of a neurotoxin with phospholipase A activity isolated from venom (Mlx-8) with affinity for muscarinic acetylcholine receptors…”
Get full text

202. Brazilian Coral Snake Phospholipases A2 Induce Neuronal Death in Primary Cultures of Hippocampal Neurons by Delazeri de Carvalho, Nathalia, Tamborelli Garcia, Raphael Caio, Lebrun, Ivo, Maria, Durvanei Augusto, Carneiro, Silvia, Afeche, Solange Castro, Lopes Sandoval, Maria Regina

Get full text