Search Results - "Sandler, Stellan"

Assessing the effectiveness of Interleukin-2 therapy in experimental type 1 diabetes by Luo, Zhengkang, Mejia-Cordova, Mariela, Hamze, Nour, Berggren, Elin, Chopra, Saloni, Safi, Bilal, Blixt, Martin, Sandler, Stellan, Singh, Kailash

“…Aim Much focus of immunotherapy for type 1 diabetes (T1D) has been devoted on selectively boosting regulatory T (Treg) cells using low dose IL-2 due to their…”
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Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells by Luo, Zhengkang, Lundin, Sara, Mejia-Cordova, Mariela, Hassani, Imane, Blixt, Martin, Hjelmqvist, Daisy, Lau, Joey, Espes, Daniel, Carlsson, Per-Ola, Sandler, Stellan, Singh, Kailash

“…The anti-inflammatory role of regulatory B cells (Breg cells) has been associated with IL-35 based on studies of experimental autoimmune uveitis and…”
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iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats by Schreiber, Olof, Petersson, Joel, Waldén, Tomas, Ahl, David, Sandler, Stellan, Phillipson, Mia, Holm, Lena

“…To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease. Colitis was induced with 5% DSS in drinking water…”
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The Increased Circulating Plasma Levels of Vascular Endothelial Growth Factor in Patients with Type 1 Diabetes Do Not Correlate to Metabolic Control by Singh, Kailash, Espes, Daniel, Sandler, Stellan

“…Aim. To characterize the plasma levels of vascular endothelial growth factor (VEGF) in type 1 diabetes mellitus (T1D) and its relation to both present and…”
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The gastric mucus layers: constituents and regulation of accumulation by Phillipson, Mia, Johansson, Malin E V, Henriksnäs, Johanna, Petersson, Joel, Gendler, Sandra J, Sandler, Stellan, Persson, A Erik G, Hansson, Gunnar C, Holm, Lena

“…The mucus layer continuously covering the gastric mucosa consists of a loosely adherent layer that can be easily removed by suction, leaving a firmly adherent…”
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Kinetics of immune cell responses in the multiple low‐dose streptozotocin mouse model of type 1 diabetes by Luo, Zhengkang, Soläng, Charlotte, Mejia‐Cordova, Mariela, Thorvaldson, Lina, Blixt, Martin, Sandler, Stellan, Singh, Kailash

“…In type 1 diabetes (T1D), the insulin‐producing β cells are destructed by immune mechanisms. It has been hypothesized that the very first immune response in…”
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Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice by Rydgren, Tobias, Vaarala, Outi, Sandler, Stellan

“…Statins are drugs well known for their cholesterol-lowering properties. Lately, statins have been shown to possess anti-inflammatory properties that might be…”
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High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases by Sällström, Johan, Carlström, Mattias, Olerud, Johan, Fredholm, Bertil B, Kouzmine, Mattias, Sandler, Stellan, Persson, A Erik G

“…A high protein intake is associated with increased glomerular filtration rate (GFR), which has been suggested to be mediated by reduced signaling of the…”
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Pancreatic islets of bank vole show signs of dysfunction after prolonged exposure to high glucose concentrations in vitro by Blixt, Martin, Niklasson, Bo, Sandler, Stellan

“…Bank voles develop glucose intolerance/diabetes mellitus when kept in captivity. We have characterized β-cell function of glucose intolerant/diabetic animals,…”
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Expression and Distribution of Somatostatin Receptor Subtypes in the Pancreatic Islets of Mice and Rats by Ludvigsen, Eva, Olsson, Richard, Stridsberg, Mats, Janson, Eva T, Sandler, Stellan

“…Somatostatin acts on specific membrane receptors (sst1–5) to inhibit exocrine and endocrine functions. The aim was to investigate the distribution of sst1–5 in…”
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Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap by RYDGREN, Tobias, BENGTSSON, Daniel, SANDLER, Stellan

“…Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an…”
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Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse by Henriksnäs, Johanna, Atuma, Christer, Phillipson, Mia, Sandler, Stellan, Engstrand, Lars, Holm, Lena

“…AIM： To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Hellcobacter pylori （HPE）. METHODS： The…”
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Cytokines affect PDX-1 expression, insulin and proinsulin secretion from iNOS deficient murine islets by Andersson, Annika K., Börjesson, Andreas, Sandgren, Johanna, Sandler, Stellan

“…In rodent islets, exposure to interleukin-1β (IL-1β) and interferon-γ (IFN-γ) induces expression of inducible nitric oxide synthase (iNOS) and subsequent…”
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Survival of an islet allograft deficient in iNOS after implantation into diabetic NOD mice by Börjesson, Andreas, Andersson, Annika K, Sandler, Stellan

“…Proinflammatory cytokines play a major role in rejection of pancreatic islet allografts and in type 1 diabetes (T1D). In rodent islets, exposure to IL-1beta…”
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Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice by Singh, Kailash, Hjort, Marcus, Thorvaldson, Lina, Sandler, Stellan

“…Regulatory T (Treg) cells are characterized by the expression of CD4, CD25 and the intracellular Foxp3. However, these markers do not indicate whether Treg…”
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Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets by GENG TIAN, SANDLER, Stellan, GYLFE, Erik, TENGHOLM, Anders

“…cAMP is a critical messenger for insulin and glucagon secretion from pancreatic β- and α-cells, respectively. Dispersed β-cells show cAMP oscillations, but the…”
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Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide by Espes, Daniel, Singh, Kailash, Sandler, Stellan, Carlsson, Per-Ola

“…Many patients with long-standing type 1 diabetes have remaining functional β-cells. This study investigated immunological differences between patients with or…”
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Amelioration of diabetes by imatinib mesylate (Gleevec®): role of ‐cell NF‐KB activation and anti‐apoptotic preconditioning by Hägerkvist, Robert, Sandler, Stellan, Mokhtari, Dariush, Welsh, Nils

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KATP Channels and Pancreatic Islet Blood Flow in Anesthetized Rats by Jansson, Leif, Kullin, Mikael, Karlsson, F. Anders, Bodin, Birgitta, Hansen, John Bondo, Sandler, Stellan

“…K ATP Channels and Pancreatic Islet Blood Flow in Anesthetized Rats Increased Blood Flow Induced by Potassium Channel Openers Leif Jansson 1 , Mikael Kullin 2…”
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Anti-IL-6R prevents experimental type 1 diabetes by Luo, Zhengkang, Hamze, Nour, Berggren, Elin, Chopra, Saloni, Blixt, Martin, Thorvaldson, Lina, Espes, Daniel, Carlsson, Per-Ola, Sandler, Stellan, Singh, Kailash

“…Abstract Type 1 diabetes (T1D) is an autoimmune disease, where the insulin producing β cells are damaged by immune attacks leading to a failure of blood…”
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