Search Results - "Sandison, Mairi E."

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer by Casciano, Jessica C., Perry, Caroline, Cohen-Nowak, Adam J., Miller, Katelyn D., Vande Voorde, Johan, Zhang, Qifeng, Chalmers, Susan, Sandison, Mairi E., Liu, Qin, Hedley, Ann, McBryan, Tony, Tang, Hsin-Yao, Gorman, Nicole, Beer, Thomas, Speicher, David W., Adams, Peter D., Liu, Xuefeng, Schlegel, Richard, McCarron, John G., Wakelam, Michael J. O., Gottlieb, Eyal, Kossenkov, Andrew V., Schug, Zachary T.

“…Background Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs),…”
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From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle by McCarron, John G, Wilson, Calum, Sandison, Mairi E, Olson, Marnie L, Girkin, John M, Saunter, Christopher, Chalmers, Susan

“…The diversity of mitochondrial arrangements, which arise from the organelle being static or moving, or fusing and dividing in a dynamically reshaping network,…”
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Intracellular Protein Determination Using Droplet-Based Immunoassays by Martino, Chiara, Zagnoni, Michele, Sandison, Mairi E, Chanasakulniyom, Mayuree, Pitt, Andrew R, Cooper, Jonathan M

“…This paper describes the implementation of a sensitive, on-chip immunoassay for the analysis of intracellular proteins, developed using microdroplet…”
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Binding of Anionic Lipids to at Least Three Nonannular Sites on the Potassium Channel KcsA is Required for Channel Opening by Marius, Phedra, Zagnoni, Michele, Sandison, Mairi E., East, J. Malcolm, Morgan, Hywel, Lee, Anthony G.

“…In addition to the annular or boundary lipids that surround the transmembrane surface of the potassium channel KcsA from Streptomyces lividans, x-ray…”
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Metal oxide-doped elastomeric materials for amplifying visible light-based antimicrobial activity by McShea, Laura, Kambo, Harjot S, Maclean, Michelle, Sandison, Mairi E

“…Healthcare-associated infection through transmission of pathogenic bacteria poses a huge threat to public health. One of the main transmission routes is via…”
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Air-Exposure Technique for the Formation of Artificial Lipid Bilayers in Microsystems by Sandison, Mairi E, Zagnoni, Michele, Morgan, Hywel

“…To develop a reliable method for on-chip bilayer lipid membrane (BLM) formation, which could be employed for use in a biosensor array platform, a polymer…”
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Formation of artificial lipid bilayers using droplet dielectrophoresis by Aghdaei, Sara, Sandison, Mairi E, Zagnoni, Michele, Green, Nicolas G, Morgan, Hywel

“…We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a…”
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Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells by Jiwaji, Meesbah, Sandison, Mairi E, Reboud, Julien, Stevenson, Ross, Daly, Rónán, Barkess, Gráinne, Faulds, Karen, Kolch, Walter, Graham, Duncan, Girolami, Mark A, Cooper, Jonathan M, Pitt, Andrew R

“…Gene therapy continues to grow as an important area of research, primarily because of its potential in the treatment of disease. One significant area where…”
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Functional, patient-derived 3D tri-culture models of the uterine wall in a microfluidic array by Busch, Caroline, Hill, Christopher J, Paterson, Karla, Mellin, Ronan, Zagnoni, Michele, Hapangama, Dharani K, Sandison, Mairi E

“…Can a functional in vitro model, containing the main cellular components of the uterine wall, be generated from cells derived from patient tissues? We present…”
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The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation by Sandison, Mairi E., Dempster, John, McCarron, John G.

“…Key points Smooth muscle cell (SMC) phenotypic conversion from a contractile to a migratory phenotype is proposed to underlie cardiovascular disease but its…”
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Optimization of the Geometry and Porosity of Microelectrode Arrays for Sensor Design by Sandison, Mairi E, Anicet, Natalie, Glidle, Andrew, Cooper, Jonathan M

“…This paper describes the systematic investigation of a range of microelectrode arrays with varying dimensions fabricated by standard photolithographic and…”
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3D Printing of Noncytotoxic High-Resolution Microchannels in Bisphenol-A Ethoxylate Dimethacrylate Tissue-Mimicking Materials by Domingo-Roca, Roger, Gilmour, Lauren, Dobre, Oana, Sarrigiannidis, Stylianos, Sandison, Mairi E, O'Leary, Richard, Jackson-Camargo, Joseph C, Mulvana, Helen E

“…The ability to create cell-laden fluidic models that mimic the geometries and physical properties of vascularized tissue would be extremely beneficial to the…”
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On-chip immunoprecipitation for protein purification by Sandison, Mairi E, Cumming, Sarah A, Kolch, Walter, Pitt, Andrew R

“…Immunoprecipitation (IP) is one of the most widely used and selective techniques for protein purification. Here, a miniaturised, polymer-supported…”
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Bilayer lipid membranes from falling droplets by Zagnoni, Michele, Sandison, Mairi E, Marius, Phedra, Morgan, Hywel

“…We describe a system that provides a rapid and simple way of forming suspended lipid bilayers within a microfluidic platform from an aqueous droplet. Bilayer…”
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Magnetite-doped polydimethylsiloxane (PDMS) for phosphopeptide enrichment by Sandison, Mairi E, Jensen, K Tveen, Gesellchen, F, Cooper, J M, Pitt, A R

“…Reversible phosphorylation plays a key role in numerous biological processes. Mass spectrometry-based approaches are commonly used to analyze protein…”
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Microdomains of muscarinic acetylcholine and Ins(1,4,5)P₃ receptors create 'Ins(1,4,5)P₃ junctions' and sites of Ca²+ wave initiation in smooth muscle by Olson, Marnie L, Sandison, Mairi E, Chalmers, Susan, McCarron, John G

“…Increases in cytosolic Ca(2+) concentration ([Ca(2+)](c)) mediated by inositol (1,4,5)-trisphosphate [Ins(1,4,5)P(3), hereafter InsP(3)] regulate activities…”
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Controlled delivery of proteins into bilayer lipid membranes on chip by Zagnoni, Michele, Sandison, Mairi E, Marius, Phedra, Lee, Anthony G, Morgan, Hywel

“…The study and the exploitation of membrane proteins for drug screening applications requires a controllable and reliable method for their delivery into an…”
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Examining the Role of Mitochondria in Ca2+ Signaling in Native Vascular Smooth Muscle by McCarron, John G., Olson, Marnie L., Wilson, Calum, Sandison, Mairi E., Chalmers, Susan

“…Mitochondrial Ca2+ uptake contributes important feedback controls to limit the time course of Ca2+signals. Mitochondria regulate cytosolic [Ca2+] over an…”
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Microdomains of muscarinic acetylcholine and InsP3 receptors create InsP3 junctions and sites of Ca2+ wave initiation in smooth muscle by Olson, Marnie L., Sandison, Mairi E., Chalmers, Susan, McCarron, John G.

“…Inositol 1,4,5-trisphosphate (InsP3)-mediated increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate activities which include division, contraction and…”
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Examining the Role of Mitochondria in Ca 2+ Signaling in Native Vascular Smooth Muscle by McCarron, John G., Olson, Marnie L., Wilson, Calum, Sandison, Mairi E., Chalmers, Susan

“…Mitochondrial Ca 2+ uptake contributes important feedback controls to limit the time course of Ca 2+ signals. Mitochondria regulate cytosolic [Ca 2+ ] over an…”
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