Search Results - "Sandip, B"

Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections by Raghuvanshi, Rinky, Bharate, Sandip B

“…Kinases are a group of therapeutic targets involved in the progression of numerous diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and…”
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Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer by Joshi, Prashant, Vishwakarma, Ram A., Bharate, Sandip B.

“…The biggest challenge associated with cancer chemotherapy is the development of cross multi-drug resistance to almost all anti-cancer agents upon chronic…”
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Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline by Bhurta, Deendyal, Bharate, Sandip B.

“…Kinases have gained an important place in the list of vital therapeutic targets because of their overwhelming clinical success in the last two decades. Among…”
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Styryl Group, a Friend or Foe in Medicinal Chemistry by Bhurta, Deendyal, Bharate, Sandip B.

“…The styryl (Ph‐CH=CH‐R) group is widely represented in medicinally important compounds, including drugs, clinical candidates, and molecular probes as it…”
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Iodine Catalyzed Oxidative Synthesis of Quinazolin-4(3H)-ones and Pyrazolo[4,3-d]pyrimidin-7(6H)-ones via Amination of sp(3) C-H Bond by Mohammed, Shabber, Vishwakarma, Ram A, Bharate, Sandip B

“…Molecular iodine catalyzed oxidative coupling of 2-aminobenzamides with aryl methyl ketones produced 2-aryl quinazolin-4(3H)-ones. The reaction performed well…”
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N‐Benzyl piperidine Fragment in Drug Discovery by Sharma, Ankita, Sharma, Mohit, Bharate, Sandip B.

“…The N‐benzyl piperidine (N‐BP) structural motif is commonly employed in drug discovery due to its structural flexibility and three‐dimensional nature…”
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Modulation of Kinases by Small Molecules for Therapeutic Management of Various Diseases - Part I by Bharate, Sandip B

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Modulation of Kinases by Small Molecules for Therapeutic Management of Various Diseases - Part II by Bharate, Sandip B

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Benzopyrone, a privileged scaffold in drug discovery: An overview of FDA‐approved drugs and clinical candidates by Sharma, Venu, Sharma, Ankita, Wadje, Bhagyashri N., Bharate, Sandip B.

“…Natural products have always served as an important source of drugs for treating various diseases. Among various privileged natural product scaffolds, the…”
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Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase by Abdullaha, Mohd, Nuthakki, Vijay K., Bharate, Sandip B.

“…The cholinesterase enzymes play a vital role in maintaining balanced levels of the neurotransmitter acetylcholine in the central nervous system. However, the…”
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Call for Papers: Natural Products Driven Medicinal Chemistry by Bharate, Sandip B, Lindsley, Craig W

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Discovery of Quinazolin-4(3H)‑ones as NLRP3 Inflammasome Inhibitors: Computational Design, Metal-Free Synthesis, and in Vitro Biological Evaluation by Abdullaha, Mohd, Mohammed, Shabber, Ali, Mehboob, Kumar, Ajay, Vishwakarma, Ram A, Bharate, Sandip B

“…NLRP3 inflammasome is an important therapeutic target for a number of human diseases. Herein, computationally designed series of quinazolin-4­(3H)-ones were…”
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Diastereoselective Desymmetrization of p‑Quinamines through Regioselective Ring Opening of Epoxides and Aziridines by Jadhav, Sandip B, Chegondi, Rambabu

“…A highly diastereoselective desymmetrization of p-quinamines via regioselective ring opening of epoxides and aziridines under mild conditions has been…”
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Chemical inactivation of two non-enveloped viruses results in distinct thermal unfolding patterns and morphological alterations by Narula, Pankhuri, Lokshman, Milan Kumar, Pathak, Sandip B, Mukherjee, Sayandip, Banerjee, Manidipa

“…Non-enveloped viruses, which lack a lipid envelope, display higher resistance to disinfectants, soaps and sanitizers compared to enveloped viruses. The capsids…”
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Phloroglucinol compounds of natural origin: synthetic aspects by Singh, Inder Pal, Sidana, Jasmeen, Bharate, Sandip B, Foley, William J

“…This review covers the synthetic aspects of various naturally occurring phloroglucinols, describing syntheses of 42 compounds and citing 137 references…”
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Multitargeted C9‐substituted ester and ether derivatives of berberrubine for Alzheimer's disease: Design, synthesis, biological evaluation, metabolic stability, and pharmacokinetics by Raghuvanshi, Rinky, Jamwal, Ashiya, Nandi, Utpal, Bharate, Sandip B.

“…Berberrubine is a naturally occurring isoquinoline alkaloid and a bioactive metabolite of berberine. Berberine exhibits a wide range of pharmacological…”
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Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids by Nuthakki, Vijay K., Mudududdla, Ramesh, Bharate, Sandip B.

“…Indoloquinoline (IQ) is an important class of naturally occurring antimalarial alkaloids, mainly represented by cryptolepine, isocryptolepine, and…”
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Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms by Cray, Jonathan A, Stevenson, Andrew, Ball, Philip, Bankar, Sandip B, Eleutherio, Elis CA, Ezeji, Thaddeus C, Singhal, Rekha S, Thevelein, Johan M, Timson, David J, Hallsworth, John E

“…Graphical abstract…”
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Identification of embelin, a 3‐undecyl‐1,4‐benzoquinone from Embelia ribes as a multitargeted anti‐Alzheimer agent by Nuthakki, Vijay K., Sharma, Ankita, Kumar, Ajay, Bharate, Sandip B.

“…Beta‐secreatse (BACE‐1) and cholinesterases are clinically validated targets of Alzheimer's disease (AD), for which natural products have provided immense…”
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Enantioselective Cu(I)-catalyzed borylative cyclization of enone-tethered cyclohexadienones and mechanistic insights by Jadhav, Sandip B., Dash, Soumya Ranjan, Maurya, Sundaram, Nanubolu, Jagadeesh Babu, Vanka, Kumar, Chegondi, Rambabu

“…The catalytic asymmetric borylation of conjugated carbonyls followed by stereoselective intramolecular cascade cyclizations with in situ generated chiral…”
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