Search Results - "Sandin, Randi H."

A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells by Michaelsen, Terje E., Thommesen, John E., Ihle, Oistein, Gregers, Tone F., Sandin, Randi H., Brekke, Ole Henrik, Sandlie, Inger

“…There are potentially two binding sites for C1q on IgG, one on each CH2 domain of the gamma heavy chains, close to the lower hinge region. It is not clear…”
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One Disulfide Bond in Front of the Second Heavy Chain Constant Region is Necessary and Sufficient for Effector Functions of Human IgG3 Without a Genetic Hinge by Michaelsen, Terje E., Brekke, Ole H., Aase, Audun, Sandin, Randi H., Bremnes, Bjorn, Sandlie, Inger

“…We have created four IgG3 mutants without a normal hinge region: (i) m0 without a genetic hinge; (ii) m0/C131S, where Cys-131 in m0 was mutated to Ser; (iii)…”
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Human IgG isotype-specific amino acid residues affecting complement-mediated cell lysis and phagocytosis by Brekke, O H, Michaelsen, T E, Aase, A, Sandin, R H, Sandlie, I

“…In this report we describe the construction of anti-5-iodo-4-hydroxy-3-nitrophenacetyl (NIP) mouse/human immunoglobulin (Ig) G4 chimeric molecules with altered…”
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