Search Results - "Sandhu, Manjinder S."

Genomics of disease risk in globally diverse populations by Gurdasani, Deepti, Barroso, Inês, Zeggini, Eleftheria, Sandhu, Manjinder S.

“…Risk of disease is multifactorial and can be shaped by socio-economic, demographic, cultural, environmental and genetic factors. Our understanding of the…”
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A general approach for haplotype phasing across the full spectrum of relatedness by O'Connell, Jared, Gurdasani, Deepti, Delaneau, Olivier, Pirastu, Nicola, Ulivi, Sheila, Cocca, Massimiliano, Traglia, Michela, Huang, Jie, Huffman, Jennifer E, Rudan, Igor, McQuillan, Ruth, Fraser, Ross M, Campbell, Harry, Polasek, Ozren, Asiki, Gershim, Ekoru, Kenneth, Hayward, Caroline, Wright, Alan F, Vitart, Veronique, Navarro, Pau, Zagury, Jean-Francois, Wilson, James F, Toniolo, Daniela, Gasparini, Paolo, Soranzo, Nicole, Sandhu, Manjinder S, Marchini, Jonathan

“…Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or by chance. Haplotype estimation in such cohorts is a…”
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Ancient human parallel lineages within North America contributed to a coastal expansion by Scheib, C L, Li, Hongjie, Desai, Tariq, Link, Vivian, Kendall, Christopher, Dewar, Genevieve, Griffith, Peter William, Mörseburg, Alexander, Johnson, John R, Potter, Amiee, Kerr, Susan L, Endicott, Phillip, Lindo, John, Haber, Marc, Xue, Yali, Tyler-Smith, Chris, Sandhu, Manjinder S, Lorenz, Joseph G, Randall, Tori D, Faltyskova, Zuzana, Pagani, Luca, Danecek, Petr, O'Connell, Tamsin C, Martz, Patricia, Boraas, Alan S, Byrd, Brian F, Leventhal, Alan, Cambra, Rosemary, Williamson, Ronald, Lesage, Louis, Holguin, Brian, Ygnacio-De Soto, Ernestine, Rosas, JohnTommy, Metspalu, Mait, Stock, Jay T, Manica, Andrea, Scally, Aylwyn, Wegmann, Daniel, Malhi, Ripan S, Kivisild, Toomas

“…Little is known regarding the first people to enter the Americas and their genetic legacy. Genomic analysis of the oldest human remains from the Americas…”
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Polygenic Prediction of Type 2 Diabetes in Africa by Chikowore, Tinashe, Ekoru, Kenneth, Vujkovi, Marijana, Gill, Dipender, Pirie, Fraser, Young, Elizabeth, Sandhu, Manjinder S, McCarthy, Mark, Rotimi, Charles, Adeyemo, Adebowale, Motala, Ayesha, Fatumo, Segun

“…Polygenic prediction of type 2 diabetes (T2D) in continental Africans is adversely affected by the limited number of genome-wide association studies (GWAS) of…”
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Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways by SORANZO, Nicole, SANNA, Serena, SANDHU, Manjinder S, HEENEY, Matthew M, DEVANEY, Joseph M, REILLY, Muredach P, RICKETTS, Sally L, WHEELER, Eleanor, GIEGER, Christian, RAKE, Dörte, DUPUIS, Josée, BOUATIA-NAJI, Nabila, LANGENBERG, Claudia, PROKOPENKO, Inga, STOLERMAN, Elliot

“…OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors…”
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The transferability of lipid loci across African, Asian and European cohorts by Kuchenbaecker, Karoline, Telkar, Nikita, Reiker, Theresa, Walters, Robin G., Lin, Kuang, Eriksson, Anders, Gurdasani, Deepti, Gilly, Arthur, Southam, Lorraine, Tsafantakis, Emmanouil, Karaleftheri, Maria, Seeley, Janet, Kamali, Anatoli, Asiki, Gershim, Millwood, Iona Y., Holmes, Michael, Du, Huaidong, Guo, Yu, Kumari, Meena, Dedoussis, George, Li, Liming, Chen, Zhengming, Sandhu, Manjinder S., Zeggini, Eleftheria

“…Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major…”
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Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load by McLaren, Paul J., Coulonges, Cedric, Bartha, István, Lenz, Tobias L., Deutsch, Aaron J., Bashirova, Arman, Buchbinder, Susan, Carrington, Mary N., Cossarizza, Andrea, Dalmau, Judith, De Luca, Andrea, Goedert, James J., Gurdasani, Deepti, Haas, David W., Herbeck, Joshua T., Johnson, Eric O., Kirk, Gregory D., Lambotte, Olivier, Luo, Ma, Mallal, Simon, van Manen, Daniëlle, Martinez-Picado, Javier, Meyer, Laurence, Miro, José M., Mullins, James I., Obel, Niels, Poli, Guido, Sandhu, Manjinder S., Schuitemaker, Hanneke, Shea, Patrick R., Theodorou, Ioannis, Walker, Bruce D., Weintrob, Amy C., Winkler, Cheryl A., Wolinsky, Steven M., Raychaudhuri, Soumya, Goldstein, David B., Telenti, Amalio, de Bakker, Paul I. W., Zagury, Jean-François, Fellay, Jacques

“…Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been underpowered to detect common variants with moderate impact on disease…”
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The Association Between the Peroxisome Proliferator-Activated Receptor-γ2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis by Gouda, Hebe N., Sagoo, Gurdeep S., Harding, Anne-Helen, Yates, Jan, Sandhu, Manjinder S., Higgins, Julian P. T.

“…The peroxisome proliferator-activated receptor-γ gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in…”
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Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials by Holmes, Michael V, DLSHTM, Newcombe, Paul, PhD, Hubacek, Jaroslav A, PhD, Sofat, Reecha, PhD, Ricketts, Sally L, PhD, Cooper, Jackie, MSc, Breteler, Monique MB, Prof, Bautista, Leonelo E, DrPH, Sharma, Pankaj, MD, Whittaker, John C, Prof, Smeeth, Liam, Prof, Fowkes, F Gerald R, Prof, Algra, Ale, Prof, Shmeleva, Veronika, MD, Szolnoki, Zoltan, PhD, Roest, Mark, PhD, Linnebank, Michael, MD, Zacho, Jeppe, MD, Nalls, Michael A, PhD, Singleton, Andrew B, PhD, Ferrucci, Luigi, MD, Hardy, John, Prof, Worrall, Bradford B, MD, Rich, Stephen S, Prof, Matarin, Mar, PhD, Norman, Paul E, FRACS, Flicker, Leon, FRACP, Almeida, Osvaldo P, Prof, van Bockxmeer, Frank M, Prof, Shimokata, Hiroshi, Prof, Khaw, Kay-Tee, Prof, Wareham, Nicholas J, Prof, Bobak, Martin, Prof, Sterne, Jonathan AC, Prof, Smith, George Davey, Prof, Talmud, Philippa J, Prof, van Duijn, Cornelia, Prof, Humphries, Steve E, Prof, Price, Jackie F, FFPH, Ebrahim, Shah, Prof, Lawlor, Debbie A, Prof, Hankey, Graeme J, FRACP, Meschia, James F, Prof, Sandhu, Manjinder S, PhD, Hingorani, Aroon D, Prof, Casas, Juan P, Dr

“…Summary Background The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview…”
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Sociodemographic patterns of health insurance coverage in Namibia by Allcock, Sophie H, Young, Elizabeth H, Sandhu, Manjinder S

“…Health insurance has been found to increase healthcare utilisation and reduce catastrophic health expenditures in a number of countries; however, coverage is…”
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The general population cohort in rural south-western Uganda: a platform for communicable and non-communicable disease studies by ASIKI, Gershim, MURPHY, Georgina, MAHER, Dermot, YOUNG, Elizabeth H, KAMALI, Anatoli, SANDHU, Manjinder S, NAKIYINGI-MIIRO, Jessica, SEELEY, Janet, NSUBUGA, Rebecca N, KARABARINDE, Alex, WASWA, Laban, BIRARO, Sam, KASAMBA, Ivan, POMILLA, Cristina

“…The General Population Cohort (GPC) was set up in 1989 to examine trends in HIV prevalence and incidence, and their determinants in rural south-western Uganda…”
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Urbanicity and lifestyle risk factors for cardiometabolic diseases in rural Uganda: a cross-sectional study by Riha, Johanna, Karabarinde, Alex, Ssenyomo, Gerald, Allender, Steven, Asiki, Gershim, Kamali, Anatoli, Young, Elizabeth H, Sandhu, Manjinder S, Seeley, Janet

“…Urban living is associated with unhealthy lifestyles that can increase the risk of cardiometabolic diseases. In sub-Saharan Africa (SSA), where the majority of…”
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Oxidation-Specific Biomarkers, Lipoprotein(a), and Risk of Fatal and Nonfatal Coronary Events by Tsimikas, Sotirios, MD, Mallat, Ziad, MD, PhD, Talmud, Philippa J., DSc, Kastelein, John J.P., MD, PhD, Wareham, Nicholas J., MBBS, PhD, Sandhu, Manjinder S., PhD, Miller, Elizabeth R., BS, Benessiano, Joelle, MD, PhD, Tedgui, Alain, PhD, Witztum, Joseph L., MD, Khaw, Kay-Tee, MBBChir, Boekholdt, S. Matthijs, MD, PhD

“…Objectives This study sought to assess whether oxidation-specific biomarkers are associated with an increased risk of coronary artery disease (CAD) events…”
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An evaluation of HIV elite controller definitions within a large seroconverter cohort collaboration by Olson, Ashley D, Meyer, Laurence, Prins, Maria, Thiebaut, Rodolphe, Gurdasani, Deepti, Guiguet, Marguerite, Chaix, Marie-Laure, Amornkul, Pauli, Babiker, Abdel, Sandhu, Manjinder S, Porter, Kholoud

“…Understanding the mechanisms underlying viral control is highly relevant to vaccine studies and elite control (EC) of HIV infection. Although numerous…”
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Burden of Diabetes and First Evidence for the Utility of HbA1c for Diagnosis and Detection of Diabetes in Urban Black South Africans: The Durban Diabetes Study by Hird, Thomas R, Pirie, Fraser J, Esterhuizen, Tonya M, O'Leary, Brian, McCarthy, Mark I, Young, Elizabeth H, Sandhu, Manjinder S, Motala, Ayesha A

“…Glycated haemoglobin (HbA1c) is recommended as an additional tool to glucose-based measures (fasting plasma glucose [FPG] and 2-hour plasma glucose [2PG]…”
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Prevalence of dyslipidaemia and associated risk factors in a rural population in South-Western Uganda: a community based survey by Asiki, Gershim, Murphy, Georgina A V, Baisley, Kathy, Nsubuga, Rebecca N, Karabarinde, Alex, Newton, Robert, Seeley, Janet, Young, Elizabeth H, Kamali, Anatoli, Sandhu, Manjinder S

“…The burden of dyslipidaemia is rising in many low income countries. However, there are few data on the prevalence of, or risk factors for, dyslipidaemia in…”
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LDL-cholesterol concentrations: a genome-wide association study by Sandhu, Manjinder S, Dr, Waterworth, Dawn M, PhD, Debenham, Sally L, PhD, Wheeler, Eleanor, PhD, Papadakis, Konstantinos, MSc, Zhao, Jing Hua, PhD, Song, Kijoung, PhD, Yuan, Xin, PhD, Johnson, Toby, PhD, Ashford, Sofie, BSc, Inouye, Michael, MSc, Luben, Robert, BSc, Sims, Matthew, BSc, Hadley, David, MSc, McArdle, Wendy, PhD, Barter, Philip, Prof, Kesäniemi, Y Antero, Prof, Mahley, Robert W, Prof, McPherson, Ruth, Prof, Grundy, Scott M, Prof, Bingham, Sheila A, Prof, Khaw, Kay-Tee, Prof, Loos, Ruth JF, PhD, Waeber, Gérard, Prof, Barroso, Inês, PhD, Strachan, David P, Prof, Deloukas, Panagiotis, PhD, Vollenweider, Peter, MD, Wareham, Nicholas J, Prof, Mooser, Vincent, MD

“…Summary Background LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that…”
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Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations by Kuchenbaecker, Karoline, Gilly, Arthur, Suveges, Daniel, Southam, Lorraine, Giannakopoulou, Olga, Kilian, Britt, Tsafantakis, Emmanouil, Karaleftheri, Maria, Farmaki, Aliki-Eleni, Gurdasani, Deepti, Kundu, Kousik, Sandhu, Manjinder S., Danesh, John, Butterworth, Adam, Barroso, Inês, Dedoussis, George, Zeggini, Eleftheria

“…Haematological traits are linked to cardiovascular, metabolic, infectious and immune disorders, as well as cancer. Here, we examine the role of genetic…”
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Lipoprotein(a) Improves Cardiovascular Risk Prediction Based on Established Risk Algorithms by Verbeek, Rutger, MD, Sandhu, Manjinder S., PhD, Hovingh, G. Kees, MD, PhD, Sjouke, Barbara, MD, Wareham, Nicholas J., MBBS, PhD, Zwinderman, Aeilko H., PhD, Kastelein, John J.P., MD, PhD, Khaw, Kay-Tee, MBBChir, Tsimikas, Sotirios, MD, Boekholdt, S. Matthijs, MD, PhD

“…According to the ACC/AHA definition of CVD, 1,556 participants were defined as case and 15,101 as control. According to the SCORE definition, 414 participants…”
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Telomere length in prospective and retrospective cancer case-control studies by Pooley, Karen A, Sandhu, Manjinder S, Tyrer, Jonathan, Shah, Mitul, Driver, Kristy E, Luben, Robert N, Bingham, Sheila A, Ponder, Bruce A J, Pharoah, Paul D P, Khaw, Kay-Tee, Easton, Douglas F, Dunning, Alison M

“…Previous studies have reported that shorter mean telomere length in lymphocytes was associated with increased susceptibility to common diseases of aging, and…”
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