Search Results - "Sandhaus, Robert A"

Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial by Chapman, Kenneth R, Prof, Burdon, Jonathan G W, MD, Piitulainen, Eeva, MD, Sandhaus, Robert A, Prof, Seersholm, Niels, MD, Stocks, James M, MD, Stoel, Berend C, PhD, Huang, Liping, MD, Yao, Zhenling, MD, Edelman, Jonathan M, MD, McElvaney, Noel G, Prof

“…Summary Background The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a…”
Get full text

The Inhibition of Serine Proteases by Serpins Is Augmented by Negatively Charged Heparin: A Concise Review of Some Clinically Relevant Interactions by Chan, Edward D, King, Paul T, Bai, Xiyuan, Schoffstall, Allen M, Sandhaus, Robert A, Buckle, Ashley M

“…Serine proteases are members of a large family of hydrolytic enzymes in which a particular serine residue in the active site performs an essential role as a…”
Get full text

Characteristics associated with SF-36 in alpha-1 antitrypsin deficiency-associated COPD: a cross-sectional analysis by Choate, Radmila, Holm, Kristen E, Sandhaus, Robert A, Mannino, David M, Strange, Charlie

“…Generic measures of health-related quality of life (HRQoL), such as the 36-Item Short Form Survey (SF-36), are widely used in assessing chronic conditions…”
Get full text

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19 by Bai, Xiyuan, Buckle, Ashley M., Vladar, Eszter K., Janoff, Edward N., Khare, Reeti, Ordway, Diane, Beckham, David, Fornis, Lorelenn B., Majluf-Cruz, Abraham, Fugit, Randolph V., Freed, Brian M., Kim, Soohyun, Sandhaus, Robert A., Chan, Edward D.

“…The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We…”
Get full text

Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria by Bai, Xiyuan, Bai, An, Honda, Jennifer R, Eichstaedt, Charles, Musheyev, Ariel, Feng, Zhihong, Huitt, Gwen, Harbeck, Ronald, Kosmider, Beata, Sandhaus, Robert A, Chan, Edward D

“…The association between non-tuberculous mycobacterial lung disease and alpha-1-antitrypsin (AAT) deficiency is likely due, in part, to underlying emphysema or…”
Get full text

Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19 by Bai, Xiyuan, Buckle, Ashley M., Vladar, Eszter K., Janoff, Edward N., Khare, Reeti, Ordway, Diane, Beckham, David, Fornis, Lorelenn B., Majluf-Cruz, Abraham, Fugit, Randolph V., Freed, Brian M., Kim, Soohyun, Sandhaus, Robert A., Chan, Edward D.

Get full text

Analysis of alpha‐1‐antitrypsin (AAT)‐regulated, glucocorticoid receptor‐dependent genes in macrophages reveals a novel host defense function of AAT by Bai, Xiyuan, Gao, Junfeng, Guan, Xiaoyu, Narum, Drew E., Fornis, Lorelenn B., Griffith, David E., Gao, Bifeng, Sandhaus, Robert A., Huang, Hua, Chan, Edward D.

“…Alpha‐1‐antitrypsin (AAT) plays a homeostatic role in attenuating excessive inflammation and augmenting host defense against microbes. We demonstrated…”
Get full text

Might your respiratory patient have alpha-1 antitrypsin deficiency? by Sandhaus, Robert A., MD, PhD, Knebel, Ann R., PhD, RN

Get full text

Alpha1-Antitrypsin Deficiency by Silverman, Edwin K, Sandhaus, Robert A

“…A 60-year-old white man presents for evaluation of progressive dyspnea. He is a former smoker with a 20-pack-year smoking history and a 10-year history of…”
Get full text

Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency by Kim, Woo Jin, Wood, Alice M, Barker, Alan F, Brantly, Mark L, Campbell, Edward J, Eden, Edward, McElvaney, Gerard, Rennard, Stephen I, Sandhaus, Robert A, Stocks, James M, Stoller, James K, Strange, Charlie, Turino, Gerard, Silverman, Edwin K, Stockley, Robert A, Demeo, Dawn L

“…The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and…”
Get full text

Clinical trial attitudes among individuals with Alpha-1 antitrypsin deficiency by Holm, Kristen E., Sandhaus, Robert A., Allison, Sheri, Strange, Charlie

“…This study examined characteristics of clinical trials that influence interest in participation among individuals with alpha-1 antitrypsin deficiency (AATD). A…”
Get full text

Scoliosis and Cardiopulmonary Outcomes in Osteogenesis Imperfecta Patients by Bronheim, Rachel, Khan, Sobiah, Carter, Erin, Sandhaus, Robert A., Raggio, Cathleen

“…Retrospective clinical study of individuals with osteogenesis imperfecta (OI). To assess the relationship between severity of scoliosis and pulmonary function,…”
Get full text

Health-related Quality of Life in Alpha-1 Antitrypsin Deficiency-associated Chronic Obstructive Pulmonary Disease by Choate, Radmila, Holm, Kristen E, Sandhaus, Robert A, Mannino, David M, Strange, Charlie

Get full text

Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19 by Bai, Xiyuan, Hippensteel, Joseph, Leavitt, Alida, Maloney, James P., Beckham, David, Garcia, Cindy, Li, Qing, Freed, Brian M., Ordway, Diane, Sandhaus, Robert A., Chan, Edward D.

“…No definitive treatment for COVID-19 exists although promising results have been reported with remdesivir and glucocorticoids. Short of a truly effective…”
Get full text

Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence by Bai, Xiyuan, Schountz, Tony, Buckle, Ashley M, Talbert, Janet L, Sandhaus, Robert A, Chan, Edward D

“…Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to inhibit SARS-CoV-2 infection and counter many of the pathogenic…”
Get more information

Randomized, Placebo-Controlled Trials in Alpha-1 Antitrypsin Deficiency by Sandhaus, Robert A

“…Alpha-1 antitrypsin deficiency (AATD) is a condition caused by the inheritance of two mutated SERPINA1 gene alleles. Individuals with AATD are at increased…”
Get full text

Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency by Siedlinski, Mateusz, Klanderman, Barbara, Sandhaus, Robert A., Barker, Alan F., Brantly, Mark L., Eden, Edward, McElvaney, N. Gerard, Rennard, Stephen I., Stocks, James M., Stoller, James K., Strange, Charlie, Turino, Gerard M., Campbell, Edward J., DeMeo, Dawn L.

“…Alpha-1 antitrypsin (AAT) deficiency and tobacco smoking are confirmed risk factors for Chronic Obstructive Pulmonary Disease. We hypothesized that variable…”
Get full text

Physical and mental health trajectories: A longitudinal SF-36 analysis in Alpha-1 antitrypsin deficiency-associated COPD by Choate, Radmila, Holm, Kristen E., Sandhaus, Robert A., Mannino, David M., Strange, Charlie

“…The Short Form 36-Item Health Survey (SF-36) is a health-related quality of life (HRQoL) measure validated in people with chronic obstructive pulmonary disease…”
Get full text

Clinical considerations in individuals with α1-antitrypsin PISZ genotype by McElvaney, Gerard N, Sandhaus, Robert A, Miravitlles, Marc, Turino, Gerard M, Seersholm, Niels, Wencker, Marion, Stockley, Robert A

“…α 1 -Antitrypsin deficiency (AATD), characterised by reduced levels or functionality of α 1 -antitrypsin (AAT), is a significantly underdiagnosed genetic…”
Get full text

Cardiopulmonary Status in Adults with Osteogenesis Imperfecta: Intrinsic Lung Disease May Contribute More Than Scoliosis by Khan, Sobiah I., Yonko, Elizabeth A., Carter, Erin M., Dyer, Debra, Sandhaus, Robert A., Raggio, Cathleen L.

“…Osteogenesis imperfecta (OI) is a heterogeneous group of collagen-related disorders characterized by osteopenia, bone fractures, spine deformities, and…”
Get full text