Abstract 649: Biobank collaboration enables cancer modeling with high quality biospecimens and data

According to the National Cancer Institute, the lack of standardized, high-quality biospecimens is one of the most significant roadblocks to progress in cancer research. This shortage especially affects the generation of murine xenograft models of human cancers. Maine, with the third largest age-adj...

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Published in:	Cancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 649
Main Authors:	Shopland, Lindsay S., Emery, Ivette, Hoffert, Todd, Aalberg, Rise, Helbig, Petra, LaPierre, Susan E., Sanders, Vicky, Mills, Kevin D., Hill, Tara, Sheikh, Aysha, Jones, Michael, Breggia, Anne, Rueter, Jens
Format:	Journal Article
Language:	English
Published:	15-07-2016
Online Access:	Get full text
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Summary:	According to the National Cancer Institute, the lack of standardized, high-quality biospecimens is one of the most significant roadblocks to progress in cancer research. This shortage especially affects the generation of murine xenograft models of human cancers. Maine, with the third largest age-adjusted cancer incidence rate in the nation, has abundant cancer specimens potentially available for research. To meet the need for quality biospecimens, the biobanks at Eastern Maine Medical Center and Maine Medical Center have established a collaboration to jointly procure cancer specimens from Maine patients. Through this collaboration, the cooperating biobanks provide researchers with tissue, blood, bone marrow and other body fluid specimens from a broad spectrum of solid and hematologic cancers. The specimens from hematologic cancer patients have > 90% viability and demonstrate anticipated biomarker composition by flow cytometry. The comparatively high frequency of engraftment of solid tumors in immunodeficient mice is also indicative of the quality of the samples procured by both repositories. Currently, the biobanks are providing fresh ovarian tumors to develop new xenograft models for poorly engrafting tumors in collaboration with the Jackson Laboratory's Patient Derived Xenograft Program. Both biobanks are integrated with clinical and pathology practices and, therefore, the specimens are annotated with in-depth, de-identified patient datasets. With support from the Maine Cancer Foundation, the biobanks have created the Maine Cancer Biospecimen Portal (MBCP), a website that provides one-stop access to annotated cancer biospecimens and to consultation services for translational research study design. The collaboration of the EMMC and MMC biobanks provides a resource of high quality biospecimens for advancement of both in vivo and in vitro translational research such as mouse models of human cancers. Citation Format: Lindsay S. Shopland, Ivette Emery, Todd Hoffert, Rise Aalberg, Petra Helbig, Susan E. LaPierre, Vicky Sanders, Kevin D. Mills, Tara Hill, Aysha Sheikh, Michael Jones, Anne Breggia, Jens Rueter. Biobank collaboration enables cancer modeling with high quality biospecimens and data. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 649.
ISSN:	0008-5472 1538-7445
DOI:	10.1158/1538-7445.AM2016-649