Search Results - "Sanders, Matthew A."

Sulfamides direct radical-mediated chlorination of aliphatic C-H bonds by Short, Melanie A, Shehata, Mina F, Sanders, Matthew A, Roizen, Jennifer L

“…Given the prevalence of aliphatic amines in bioactive small molecules, amine derivatives are opportune as directing groups. Herein, sulfamides serve as amine…”
Get full text

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle by Sanders, Matthew A., Madoux, Franck, Mladenovic, Ljiljana, Zhang, Huamei, Ye, Xiangqun, Angrish, Michelle, Mottillo, Emilio P., Caruso, Joseph A., Halvorsen, Geoff, Roush, William R., Chase, Peter, Hodder, Peter, Granneman, James G.

“…Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and…”
Get full text

Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs by Sanders, Matthew A., Haynes, Brittany, Nangia-Makker, Pratima, Polin, Lisa A., Shekhar, Malathy P.

“…Platinum drug-induced cross-link repair requires the concerted activities of translesion synthesis (TLS), Fanconi anemia (FA), and homologous recombination…”
Get full text

Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator by Tseng, Yan Yuan, Sanders, Matthew A., Zhang, Huamei, Zhou, Li, Chou, Chia-Yi, Granneman, James G.

“…Alpha/beta hydrolase domain-containing protein 5 (ABHD5) is a highly conserved protein that regulates various lipid metabolic pathways via interactions with…”
Get full text

Molecular Basis of ABHD5 Lipolysis Activation by Sanders, Matthew A., Zhang, Huamei, Mladenovic, Ljiljana, Tseng, Yan Yuan, Granneman, James G.

“…Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose…”
Get full text

Colon cancer stem cells: implications in carcinogenesis by Sanders, Matthew A, Majumdar, Adhip P N

“…The cancer stem cell model was described for hematologic malignancies in 1997 and since then evidence has emerged to support it for many solid tumors as well,…”
Get full text

Molecular Modeling of ABHD5 Structure and Ligand Recognition by Shahoei, Rezvan, Pangeni, Susheel, Sanders, Matthew A, Zhang, Huamei, Mladenovic-Lucas, Ljiljana, Roush, William R, Halvorsen, Geoff, Kelly, Christopher V, Granneman, James G, Huang, Yu-Ming M

“…Alpha/beta hydrolase domain-containing 5 (ABHD5), also termed CGI-58, is the key upstream activator of adipose triglyceride lipase (ATGL), which plays an…”
Get full text

DOCK5 and DOCK1 Regulate Caco-2 Intestinal Epithelial Cell Spreading and Migration on Collagen IV by Sanders, Matthew A., Ampasala, Dinakar, Basson, Marc D.

“…We observed previously that combined small interfering RNAs (siRNAs) targeting CrkII and CrkL, known activators of guanine nucleotide exchange factor DOCK1,…”
Get full text

The Motogenic Effects of Cyclic Mechanical Strain on Intestinal Epithelial Monolayer Wound Closure Are Matrix Dependent by Zhang, Jianhu, Owen, Cheri R., Sanders, Matthew A., Turner, Jerrold R., Basson, Marc D.

“…Background & Aims: Complex deformation during normal digestion due to peristalsis or villous motility may be trophic for the intestinal mucosa. Because tissue…”
Get full text

Versatile Triphenylphosphine-Containing Polymeric Catalysts and Elucidation of Structure–Function Relationships by Sanders, Matthew A., Chittari, Supraja S., Sherman, Nicole, Foley, Jack R., Knight, Abigail S.

“…Synthetic polymers are a modular solution to bridging the two most common classes of catalysts: proteins and small molecules. Polymers offer the synthetic…”
Get full text

Lipid droplet monolayer protein binding and complexation by Parveen, Shahnaz, Gandhi, Sonali A., Sanders, Matthew A., Granneman, James G., Kelly, Christopher V.

Get full text

Leveraging Triphenylphosphine-Containing Polymers to Explore Design Principles for Protein-Mimetic Catalysts by Sanders, Matthew A., Chittari, Supraja S., Foley, Jack R., Swofford, William M., Elder, Bridgette M., Knight, Abigail S.

“…Complex interactions between noncoordinating residues are significant yet commonly overlooked components of macromolecular catalyst function. While these…”
Get full text

The Gargle Effect: Rinsing the Mouth With Glucose Enhances Self-Control by Sanders, Matthew A., Shirk, Steve D., Burgin, Chris J., Martin, Leonard L.

Get full text

Monomer Composition as a Mechanism to Control the Self-Assembly of Diblock Oligomeric Peptide–Polymer Amphiphiles by Allen, Benjamin P., Pinky, Sabila K., Beard, Emily E., Gringeri, Abigail A., Calzadilla, Nicholas, Sanders, Matthew A., Yingling, Yaroslava G., Knight, Abigail S.

“…Diblock oligomeric peptide–polymer amphiphiles (PPAs) are biohybrid materials that offer versatile functionality by integrating the sequence-dependent…”
Get full text

Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins by Zhang, Jianhu, Li, Wei, Sanders, Matthew A., Sumpio, Bauer E., Asit, Panja, Basson, Marc D.

“…ABSTRACT Repetitive mechanical deformation may stimulate intestinal epithelial proliferation. Because the extracellular matrix modulates static intestinal…”
Get full text

Four-color fluorescence cross-correlation spectroscopy with one laser and one camera by Gandhi, Sonali A, Sanders, Matthew A, Granneman, James G, Kelly, Christopher V

“…The diffusion and reorganization of phospholipids and membrane-associated proteins are fundamental for cellular function. Fluorescence cross-correlation…”
Get full text

Hollywood in China: How American Popular Culture Shapes Chinese Views of the “Beautiful Imperialist” – An Experimental Analysis by Gries, Peter, Sanders, Matthew A., Stroup, David R., Cai, Huajian

“…While most mainland Chinese today have extremely few direct contacts with either America or Americans, their indirect contacts with both, via globalized…”
Get full text

Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization by Sanders, Matthew A, Brahemi, Ghali, Nangia-Makker, Pratima, Balan, Vitaly, Morelli, Matteo, Kothayer, Hend, Westwell, Andrew D, Shekhar, Malathy P V

“…Protein ubiquitination is important for cell signaling, DNA repair, and proteasomal degradation, and it is not surprising that alterations in ubiquitination…”
Get full text

p130cas but Not Paxillin Is Essential for Caco-2 Intestinal Epithelial Cell Spreading and Migration on Collagen IV by Sanders, Matthew A., Basson, Marc D.

“…We have previously observed that collagen IV regulates Caco-2 intestinal epithelial cell spreading and migration via Src kinase and stimulates Src-dependent…”
Get full text

Methods for making and observing model lipid droplets by Gandhi, Sonali A., Parveen, Shahnaz, Alduhailan, Munirah, Tripathi, Ramesh, Junedi, Nasser, Saqallah, Mohammad, Sanders, Matthew A., Hoffmann, Peter M., Truex, Katherine, Granneman, James G., Kelly, Christopher V.

“…We present methods for making and testing the membrane biophysics of model lipid droplets (LDs). Methods are described for imaging LDs ranging in size from 0.1…”
Get full text