Search Results - "Sanders, John M."

Discovery of a chemical probe for PRDM9 by Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Ivanochko, Danton, Organ, Shawna L., Bok, Jabez, Ho, Jessica Sook Yuin, Gay, Florence P. H., Li, Fengling, Blazer, Levi, Eram, Mohammad S., Halabelian, Levon, Dilworth, David, Luciani, Genna M., Lima-Fernandes, Evelyne, Wu, Qin, Loppnau, Peter, Palmer, Nathan, Talib, S. Zakiah A., Brown, Peter J., Schapira, Matthieu, Kaldis, Philipp, O’Hagan, Ronan C., Guccione, Ernesto, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Sanders, John M., Kattar, Solomon D., Bennett, D. Jonathan, Nicholson, Benjamin, Vedadi, Masoud

“…PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of…”
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Angiogenesis in Skeletal Muscle Precede Improvements in Peak Oxygen Uptake in Peripheral Artery Disease Patients by Duscha, Brian D, Robbins, Jennifer L, Jones, William S, Kraus, William E, Lye, R John, Sanders, John M, Allen, Jason D, Regensteiner, Judith G, Hiatt, William R, Annex, Brian H

“…OBJECTIVE—Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. The…”
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Molecular Imaging of Endothelial Vascular Cell Adhesion Molecule-1 Expression and Inflammatory Cell Recruitment During Vasculogenesis and Ischemia-Mediated Arteriogenesis by BEHM, Carolyn Z, KAUFMANN, Beat A, CARR, Chad, LANKFORD, Miles, SANDERS, John M, ROSE, C. Edward, KAUL, Sanjiv, LINDNER, Jonathan R

“…Inflammatory responses contribute to vascular remodeling during tissue repair or ischemia. We hypothesized that inflammatory cell recruitment and endothelial…”
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Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain by Stachel, Shawn J, Sanders, John M, Henze, Darrell A, Rudd, Mike T, Su, Hua-Poo, Li, Yiwei, Nanda, Kausik K, Egbertson, Melissa S, Manley, Peter J, Jones, Kristen L. G, Brnardic, Edward J, Green, Ahren, Grobler, Jay A, Hanney, Barbara, Leitl, Michael, Lai, Ming-Tain, Munshi, Vandna, Murphy, Dennis, Rickert, Keith, Riley, Daniel, Krasowska-Zoladek, Alicja, Daley, Christopher, Zuck, Paul, Kane, Stephanie A, Bilodeau, Mark T

“…We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and…”
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NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells by Gruber, Florian, Mayer, Herbert, Lengauer, Barbara, Mlitz, Veronika, Sanders, John M, Kadl, Alexandra, Bilban, Martin, de Martin, Rainer, Wagner, Oswald, Kensler, Thomas W, Yamamoto, Masayuki, Leitinger, Norbert, Tschachler, Erwin

“…Long-wavelength ultraviolet (UVA-1) radiation causes oxidative stress that modifies cellular molecules. To defend themselves against noxious oxidation…”
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Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice by Harry, Brian L, Sanders, John M, Feaver, Ryan E, Lansey, Melissa, Deem, Tracy L, Zarbock, Alexander, Bruce, Anthony C, Pryor, Andrew W, Gelfand, Bradley D, Blackman, Brett R, Schwartz, Martin A, Ley, Klaus

“…OBJECTIVE—Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) has recently been shown to form an essential element of a mechanosensory complex that…”
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Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis by Orr, A. Wayne, Stockton, Rebecca, Simmers, Michael B, Sanders, John M, Sarembock, Ian J, Blackman, Brett R, Schwartz, Martin Alexander

“…Elevated permeability of the endothelium is thought to be crucial in atherogenesis because it allows circulating lipoproteins to access subendothelial…”
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Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV by Schreier, John D., Embrey, Mark W., Raheem, Izzat T., Barbe, Guillaume, Campeau, Louis-Charles, Dubost, David, McCabe Dunn, Jamie, Grobler, Jay, Hartingh, Timothy J., Hazuda, Daria J., Klein, Daniel, Miller, Michael D., Moore, Keith P., Nguyen, Natalie, Pajkovic, Natasa, Powell, David A., Rada, Vanessa, Sanders, John M., Sisko, John, Steele, Thomas G., Wai, John, Walji, Abbas, Xu, Min, Coleman, Paul J.

“…[Display omitted] HIV integrase strand transfer inhibitors (InSTIs) represent an important class of antiviral therapeutics with proven efficacy and excellent…”
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Improved Survival and Reduced Vascular Permeability by Eliminating or Blocking 12/15-Lipoxygenase in Mouse Models of Acute Lung Injury (ALI) by Zarbock, Alexander, DiStasi, Matthew R, Smith, Emily, Sanders, John M, Kronke, Gerhard, Harry, Brian L, von Vietinghoff, Sibylle, Buscher, Konrad, Nadler, Jerry L, Ley, Klaus

“…Acute lung injury (ALI) is a prevalent disease associated with high mortality. 12/15-lipoxygenase (12/15-LO) is an enzyme producing 12-hydroxyeicosatetraenoic…”
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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT) by Harrison, Scott T, Poslusney, Michael S, Mulhearn, James J, Zhao, Zhijian, Kett, Nathan R, Schubert, Jeffrey W, Melamed, Jeffrey Y, Allison, Timothy J, Patel, Sangita B, Sanders, John M, Sharma, Sujata, Smith, Robert F, Hall, Dawn L, Robinson, Ronald G, Sachs, Nancy A, Hutson, Pete H, Wolkenberg, Scott E, Barrow, James C

“…3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These…”
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Adeno-associated virus serotype 9-mediated overexpression of extracellular superoxide dismutase improves recovery from surgical hind-limb ischemia in BALB/c mice by Saqib, Amina, MBBS, Prasad, Konkal-Matt R., PhD, Katwal, Arabindra B., MBBS, Sanders, John M., BS, Lye, R. John, PhD, French, Brent A., PhD, Annex, Brian H

“…Objective Neovascularization is a physiologic repair process that partly depends on nitric oxide. Extracellular superoxide dismutase (EcSOD) is the major…”
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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts by Brnardic, Edward J., Fraley, Mark E., Garbaccio, Robert M., Layton, Mark E., Sanders, John M., Culberson, Chris, Jacobson, Marlene A., Magliaro, Brian C., Hutson, Pete H., O’Brien, Julie A., Huszar, Sarah L., Uslaner, Jason M., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Sur, Sylvie M., Hartman, George D.

“…Hit to lead optimization of oxazolidinones as positive allosteric modulators of mGluR2 is described. An optimized lead compound was found to be brain penetrant…”
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Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice by PHILLIPS, J. William, BARRINGHAUS, Kurt G, SANDERS, John M, HESSELBACHER, Sean E, CZARNIK, Ann C, MANKA, David, VESTWEBER, Dietmar, LEY, Klaus, SAREMBOCK, Ian J

“…Emerging data suggest that P-selectin, by controlling adhesion of white blood cells, may be important in limiting the response to vascular injury. We tested…”
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Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes by Yajima, Shunsuke, Hara, Kodai, Sanders, John M, Yin, Fenglin, Ohsawa, Kanju, Wiesner, Jochen, Jomaa, Hassan, Oldfield, Eric

“…We have obtained the single-crystal X-ray crystallographic structures of the bisphosphonates [(1-isoquinolinylamino)methylene]-1,1-bisphosphonate and…”
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Integrin Agonists as Adjuvants in Chemotherapy for Melanoma by SCHWARTZ, Martin A, MCROBERTS, Kevin, COYNER, Matthew, ANDARAWEWA, Kumari L, FRIERSON, Henry F, SANDERS, John M, SWENSON, Stephen, MARKLAND, Frank, CONAWAY, Mark R, THEODORESCU, Dan

“…Purpose: Metastatic melanomas are generally resistant to chemotherapy and radiation, even when wild-type for p53. These tumors often grow in small nests where…”
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Arterial Macrophages and Regenerating Endothelial Cells Express P-Selectin in Atherosclerosis-Prone Apolipoprotein E-Deficient Mice by Li, Guohong, Sanders, John M., Phan, Elizabeth T., Ley, Klaus, Sarembock, Ian J.

“…P-selectin expression has been reported in platelets, endothelial cells, and vascular smooth muscle cells in response to vascular injury. Here, we report…”
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Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1 by KAUFMANN, Beat A, SANDERS, John M, DAVIS, Christopher, XIE, Aris, ALDRED, Patrick, SAREMBOCK, Ian J, LINDNER, Jonathan R

“…The ability to image vascular inflammatory responses may allow early diagnosis and treatment of atherosclerosis. We hypothesized that molecular imaging of…”
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Optimal π-Stacking Interaction Energies in Parallel-Displaced Aryl/Aryl Dimers are Predicted by the Dimer Heavy Atom Count by Sanders, John M

“…It is generally accepted that large basis sets are required for the accurate calculation of interaction energies for weakly bound aryl dimers, but it has…”
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Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes by PHILLIPS, J. William, BARRINGHAUS, Kurt G, SANDERS, John M, ZANDONG YANG, MENG CHEN, HESSELBACHER, Sean, CZARNIK, Ann C, LEY, Klaus, NADLER, Jerry, SAREMBOCK, Ian J

“…Hyperglycemia (HG) and hyperinsulinemia (HI) may be factors enhancing the atherosclerotic complications of diabetes. We hypothesized that specific feeding of…”
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Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity by Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W

“…Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals…”
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