Search Results - "Sanders, J Michael"
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Disposition of the Emerging Brominated Flame Retardant, 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate, in Female SD Rats and Male B6C3F1 Mice: Effects of Dose, Route, and Repeated Administration
Published in Toxicological sciences (01-12-2016)“…2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB; MW 549.92 g/mol; CAS 183658-27-7) is a brominated component of flame retardant mixtures used as substitutes…”
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Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats
Published in Archives of toxicology (01-04-2017)“…N , N -dimethyl- p -toluidine (DMPT), an accelerant for methyl methacrylate monomers in medical devices, was a liver carcinogen in male and female F344/N rats…”
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Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle
Published in Toxicologic pathology (01-02-2011)“…Two-year toxicity studies were conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. With…”
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Disposition and metabolism of 2′,2′”-Dithiobisbenzanilide in rodents following intravenous and oral administration and dermal application
Published in Toxicology reports (01-01-2020)“…•2′,2′′′-Dithiobisbenzanilide (DTBBA) is a chemical used as a peptizing agent for rubber.•Humane exposure to DTBBA is possible via oral and dermal…”
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Shearing Behavior of Tire-Derived Aggregate with Large Particle Size. I: Internal and Concrete Interface Direct Shear
Published in Journal of geotechnical and geoenvironmental engineering (01-10-2017)“…AbstractTire-derived aggregate (TDA) has been used widely in civil engineering applications such as highway embankments, light rail foundations, landslide…”
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METTĀNOIA IN THOMAS PYNCHON’S BUDDHIST TRILOGY
Published in Religion & literature (2020)“…This article argues for the centrality of Buddhism in Thomas Pynchon’s fiction. The Crying of Lot 49, Vineland, and Bleeding Edge make a Buddhist Trilogy. As…”
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Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route and repeated administration
Published in Xenobiotica (04-03-2017)“…1. Bis(2-ethylhexyl)-tetrabromophthalate (BEH-TEBP; CAS No. 26040-51-7; PubChem CID: 117291; MW 706.15 g/mol, elsewhere: TeBrDEPH, TBPH, or BEHTBP) is used as…”
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Shearing Behavior of Tire-Derived Aggregate with Large Particle Size. II: Cyclic Simple Shear
Published in Journal of geotechnical and geoenvironmental engineering (01-10-2017)“…AbstractAlthough tire-derived aggregate (TDA) has been used widely as lightweight fill in civil engineering applications, the properties governing its response…”
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Absorption, Distribution, Metabolism, and Excretion of 2,2-Bis(bromomethyl)-1,3-propanediol in Male Fischer-344 Rats
Published in Drug metabolism and disposition (01-02-2009)“…2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant, previously shown to be a multisite carcinogen in experimental animals. Studies were…”
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Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A
Published in Toxicology and applied pharmacology (01-05-2016)“…Chronic oral treatment of tetrabromobisphenol A (TBBPA) to female Wistar Han rats resulted in increased incidence of cell proliferation at 250mg/kg and tumor…”
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Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure
Published in Toxicology and applied pharmacology (15-01-2018)“…β-N-methylamino-l-alanine (L-BMAA) is produced by cyanobacteria (blue-green algae). Human exposure to L-BMAA occurs via consumption of L-BMAA-contaminated…”
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Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP)
Published in Toxicology and applied pharmacology (15-11-2016)“…2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) are novel brominated flame retardants used in consumer…”
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Estimation of tetrabromobisphenol A (TBBPA) percutaneous uptake in humans using the parallelogram method
Published in Toxicology and applied pharmacology (01-12-2015)“…Tetrabromobisphenol A (TBBPA) is currently the world's highest production volume brominated flame retardant. Humans are frequently exposed to TBBPA by the…”
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Gene expression changes in immune response pathways following oral administration of tetrabromobisphenol A (TBBPA) in female Wistar Han rats
Published in Toxicology letters (15-04-2017)“…•Perturbation of biological pathways in TBBPA-exposed female rats was studied.•Gene expression changes were observed with microarray and validated with…”
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Disposition and metabolism of 2,2′-dimorpholinodiethyl ether in sprague dawley rats and B6C3F1/N mice after oral, intravenous administration, and dermal application
Published in Xenobiotica (01-11-2020)“…The specialty amine catalyst 2,2′-dimorpholinodiethyl ether (DMDEE) is a high-production volume chemical used in the production of flexible foam,…”
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The fate of β-hexabromocyclododecane in female C57BL/6 mice
Published in Toxicological sciences (01-08-2013)“…1,2,5,6,9,10-Hexabromocyclododecane (HBCD) is a high production volume cycloaliphatic used as an additive flame retardant primarily in polystyrene foam…”
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The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration
Published in Xenobiotica (03-10-2017)“…1. It was important to investigate the disposition of decabromodiphenyl ethane (DBDPE) based on concerns over its structural similarities to decabromodiphenyl…”
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Disposition and kinetics of tetrabromobisphenol A in female Wistar Han rats
Published in Toxicology reports (01-01-2014)“…Tetrabromobisphenol A (TBBPA) is the brominated flame retardant with the largest production volume worldwide. NTP 2-year bioassays found TBBPA dose-dependent…”
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Proposed mechanistic description of dose-dependent BDE-47 urinary elimination in mice using a physiologically based pharmacokinetic model
Published in Toxicology and applied pharmacology (01-12-2013)“…Polybrominated diphenyl ethers (PBDEs) have been used in a wide variety of consumer applications as additive flame retardants. In North America, scientists…”
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Toxicology and Carcinogenesis Study of Senna in C3B6.129F1-Trp53 tm1Brd N12 Haploinsufficient Mice
Published in Toxicologic pathology (01-07-2013)“…Senna is a pod or leaf of Senna alexandrina P. Mill and is used as a stimulant laxative. In the large intestine, bacterial enzymes reduce sennosides to…”
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