Search Results - "Sanders, David W."

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies by Sanders, David W., Kaufman, Sarah K., DeVos, Sarah L., Sharma, Apurwa M., Mirbaha, Hilda, Li, Aimin, Barker, Scarlett J., Foley, Alex C., Thorpe, Julian R., Serpell, Louise C., Miller, Timothy M., Grinberg, Lea T., Seeley, William W., Diamond, Marc I.

“…Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique…”
Get full text

Composition-dependent thermodynamics of intracellular phase separation by Riback, Joshua A., Zhu, Lian, Ferrolino, Mylene C., Tolbert, Michele, Mitrea, Diana M., Sanders, David W., Wei, Ming-Tzo, Kriwacki, Richard W., Brangwynne, Clifford P.

“…Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies represent membraneless organelles, or condensates, that form via…”
Get full text

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization by Sanders, David W., Kedersha, Nancy, Lee, Daniel S.W., Strom, Amy R., Drake, Victoria, Riback, Joshua A., Bracha, Dan, Eeftens, Jorine M., Iwanicki, Allana, Wang, Alicia, Wei, Ming-Tzo, Whitney, Gena, Lyons, Shawn M., Anderson, Paul, Jacobs, William M., Ivanov, Pavel, Brangwynne, Clifford P.

“…Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate…”
Get full text

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo by Kaufman, Sarah K., Sanders, David W., Thomas, Talitha L., Ruchinskas, Allison J., Vaquer-Alicea, Jaime, Sharma, Apurwa M., Miller, Timothy M., Diamond, Marc I.

“…Tauopathies are neurodegenerative disorders that affect distinct brain regions, progress at different rates, and exhibit specific patterns of tau accumulation…”
Get full text

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation by Mirbaha, Hilda, Holmes, Brandon B., Sanders, David W., Bieschke, Jan, Diamond, Marc I.

“…Tau amyloid assemblies propagate aggregation from the outside to the inside of a cell, which may mediate progression of the tauopathies. The critical size of…”
Get full text

Neuronal activity enhances tau propagation and tau pathology in vivo by Wu, Jessica W, Hussaini, S Abid, Bastille, Isle M, Rodriguez, Gustavo A, Mrejeru, Ana, Rilett, Kelly, Sanders, David W, Cook, Casey, Fu, Hongjun, Boonen, Rick A C M, Herman, Mathieu, Nahmani, Eden, Emrani, Sheina, Figueroa, Y Helen, Diamond, Marc I, Clelland, Catherine L, Wray, Selina, Duff, Karen E

“…The authors show that tau can be released by neurons and transferred to other neurons via the extracellular space. Moreover, they show that enhancing neuronal…”
Get full text

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation by Sanders, David W, Jumper, Chanelle C, Ackerman, Paul J, Bracha, Dan, Donlic, Anita, Kim, Hahn, Kenney, Devin, Castello-Serrano, Ivan, Suzuki, Saori, Tamura, Tomokazu, Tavares, Alexander H, Saeed, Mohsan, Holehouse, Alex S, Ploss, Alexander, Levental, Ilya, Douam, Florian, Padera, Robert F, Levy, Bruce D, Brangwynne, Clifford P

“…Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry…”
Get full text

Size distributions of intracellular condensates reflect competition between coalescence and nucleation by Lee, Daniel S. W., Choi, Chang-Hyun, Sanders, David W., Beckers, Lien, Riback, Joshua A., Brangwynne, Clifford P., Wingreen, Ned S.

“…Phase separation of biomolecules into condensates has emerged as a mechanism for intracellular organization and affects many intracellular processes, including…”
Get full text

Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery by Carson, Jeffrey L, Terrin, Michael L, Noveck, Helaine, Sanders, David W, Chaitman, Bernard R, Rhoads, George G, Nemo, George, Dragert, Karen, Beaupre, Lauren, Hildebrand, Kevin, Macaulay, William, Lewis, Courtland, Cook, Donald Richard, Dobbin, Gwendolyn, Zakriya, Khwaja J, Apple, Fred S, Horney, Rebecca A, Magaziner, Jay

“…This trial compared a restrictive hemoglobin threshold with a liberal threshold for blood transfusion among hip-surgery patients with risk factors for CVD. The…”
Get full text

Prions and Protein Assemblies that Convey Biological Information in Health and Disease by Sanders, David W., Kaufman, Sarah K., Holmes, Brandon B., Diamond, Marc I.

“…Prions derived from the prion protein (PrP) were first characterized as infectious agents that transmit pathology between individuals. However, the majority of…”
Get full text

Propagation of prions causing synucleinopathies in cultured cells by Woerman, Amanda L., Stöhr, Jan, Aoyagi, Atsushi, Rampersaud, Ryan, Krejciova, Zuzana, Watts, Joel C., Ohyama, Takao, Patel, Smita, Widjaja, Kartika, Oehler, Abby, Sanders, David W., Diamond, Marc I., Seeley, William W., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Südhof, Thomas C., Giles, Kurt, Prusiner, Stanley B.

“…Increasingly, evidence argues that many neurodegenerative diseases, including progressive supranuclear palsy (PSP), are caused by prions, which are…”
Get full text

Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial by Carson, Jeffrey L, Prof, Sieber, Frederick, Prof, Cook, Donald Richard, MD, Hoover, Donald R, Prof, Noveck, Helaine, MPH, Chaitman, Bernard R, Prof, Fleisher, Lee, Prof, Beaupre, Lauren, PhD, Macaulay, William, Prof, Rhoads, George G, Prof, Paris, Barbara, MD, Zagorin, Aleksandra, DNP, Sanders, David W, MD, Zakriya, Khwaja J, MD, Magaziner, Jay, Prof

“…Summary Background Blood transfusion might affect long-term mortality by changing immune function and thus potentially increasing the risk of subsequent…”
Get full text

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system by Saha, Itika, Yuste-Checa, Patricia, Da Silva Padilha, Miguel, Guo, Qiang, Körner, Roman, Holthusen, Hauke, Trinkaus, Victoria A., Dudanova, Irina, Fernández-Busnadiego, Rubén, Baumeister, Wolfgang, Sanders, David W., Gautam, Saurabh, Diamond, Marc I., Hartl, F. Ulrich, Hipp, Mark S.

“…Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The…”
Get full text

DnaJC7 specifically regulates tau seeding by Perez, Valerie Ann, Sanders, David W, Mendoza-Oliva, Ayde, Stopschinski, Barbara Elena, Mullapudi, Vishruth, White, Charles L, Joachimiak, Lukasz A, Diamond, Marc I

“…Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau…”
Get full text

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions by Park, Jinyoung, Wu, Yanwei, Shao, Wei, Gendron, Tania F., van der Spek, Sophie J.F., Sultanakhmetov, Grigorii, Basu, Avik, Castellanos Otero, Paula, Jones, Caroline J., Jansen-West, Karen, Daughrity, Lillian M., Phanse, Sadhna, del Rosso, Giulia, Tong, Jimei, Castanedes-Casey, Monica, Jiang, Lulu, Libera, Jenna, Oskarsson, Björn, Dickson, Dennis W., Sanders, David W., Brangwynne, Clifford P., Emili, Andrew, Wolozin, Benjamin, Petrucelli, Leonard, Zhang, Yong-Jie

“…C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are…”
Get full text

Risk Factors for Early Postoperative Morbidity and Mortality following Extremity Metastatic Pathologic or Impending Fracture Fixation by Wang, Patrick Qi, Charron, Brynn P, Hali, Kalter, Raleigh, Matthew, Del Balso, Christopher, Macleod, Mark D, Sanders, David W, Lawendy, Abdel-Rahman

“…As cancer survivorship continues to improve, the perioperative morbidity and mortality following surgical treatment of metastatic bone disease become an…”
Get full text

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition by Eskandari-Sedighi, Ghazaleh, Daude, Nathalie, Gapeshina, Hristina, Sanders, David W, Kamali-Jamil, Razieh, Yang, Jing, Shi, Beipei, Wille, Holger, Ghetti, Bernardino, Diamond, Marc I, Janus, Christopher, Westaway, David

“…MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical…”
Get full text

Factors affecting transfusion requirement after hip fracture: Can we reduce the need for blood? by Desai, Sagar J., MD, Wood, Kristi S., MSc, MD, Marsh, Jackie, MSc, PhD, Bryant, Dianne, MSc, PhD, Abdo, Hussein, BSc, Lawendy, Abdel-Rahman, MSc, MD, Sanders, David W., MD, MSc

“…Background Hip fractures are common injuries that result in blood loss and frequently require the transfusion of blood products. We sought to identify risk…”
Get full text

The Severity of Microvascular Dysfunction Due to Compartment Syndrome Is Diminished by the Systemic Application of CO-Releasing Molecule-3 by Lawendy, Abdel-Rahman, Bihari, Aurelia, Sanders, David W, Potter, Richard F, Cepinskas, Gediminas

“…OBJECTIVES:To examine the protective effects of carbon monoxide (CO), liberated from a novel CO-releasing molecule (CORM-3), on the function of compartment…”
Get full text

Factors Predictive of Early Complications Following Total Ankle Arthroplasty by Del Balso, Christopher, Halai, Mansur M., MacLeod, Mark D., Sanders, David W., Rahman Lawendy, Abdel

“…Background: The safety of outpatient total ankle arthroplasty (TAA), and factors predictive of early complications are poorly understood. The objective of this…”
Get full text