Search Results - "Sanders, A"

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning by Sanders, Timothy A., Llagostera, Esther, Barna, Maria

“…This study uses single-cell real-time imaging to show that sonic hedgehog (SHH) is produced in the form of a particle that is transported along a novel class…”
Get full text

Carbon Dots for Efficient Small Interfering RNA Delivery and Gene Silencing in Plants by Schwartz, Steven H, Hendrix, Bill, Hoffer, Paul, Sanders, Rick A, Zheng, Wei

“…The initiation of RNA interference (RNAi) by topically applied small interfering RNA has potential applications for plant functional genomics, crop improvement…”
Get full text

Viral and bacterial interactions in the upper respiratory tract by Bosch, Astrid A T M, Biesbroek, Giske, Trzcinski, Krzysztof, Sanders, Elisabeth A M, Bogaert, Debby

“…Respiratory infectious diseases are mainly caused by viruses or bacteria that often interact with one another. Although their presence is a prerequisite for…”
Get full text

Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome by Grob, Tim, Al Hinai, Adil S.A., Sanders, Mathijs A., Kavelaars, François G., Rijken, Melissa, Gradowska, Patrycja L., Biemond, Bart J., Breems, Dimitri A., Maertens, Johan, van Marwijk Kooy, Marinus, Pabst, Thomas, de Weerdt, Okke, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Huls, Gerwin A., Cornelissen, Jan J., Beverloo, H. Berna, Löwenberg, Bob, Jongen-Lavrencic, Mojca, Valk, Peter J.M.

“…Substantial heterogeneity within mutant TP53 acute myeloid leukemia (AML) and myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact…”
Get full text

The landscape of somatic mutation in normal colorectal epithelial cells by Lee-Six, Henry, Olafsson, Sigurgeir, Ellis, Peter, Osborne, Robert J., Sanders, Mathijs A., Moore, Luiza, Georgakopoulos, Nikitas, Torrente, Franco, Noorani, Ayesha, Goddard, Martin, Robinson, Philip, Coorens, Tim H. H., O’Neill, Laura, Alder, Christopher, Wang, Jingwei, Fitzgerald, Rebecca C., Zilbauer, Matthias, Coleman, Nicholas, Saeb-Parsy, Kourosh, Martincorena, Inigo, Campbell, Peter J., Stratton, Michael R.

“…The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal…”
Get full text

How do informal information sources influence women's decision-making for birth? A meta-synthesis of qualitative studies by Sanders, Ruth A, Crozier, Kenda

“…Women approach birth using various methods of preparation drawing from conventional healthcare providers alongside informal information sources (IIS) outside…”
Get full text

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver by Brunner, Simon F., Roberts, Nicola D., Wylie, Luke A., Moore, Luiza, Aitken, Sarah J., Davies, Susan E., Sanders, Mathijs A., Ellis, Pete, Alder, Chris, Hooks, Yvette, Abascal, Federico, Stratton, Michael R., Martincorena, Inigo, Hoare, Matthew, Campbell, Peter J.

“…The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis and non-alcoholic fatty liver disease, with the clinical spectrum…”
Get full text

The mutational landscape of normal human endometrial epithelium by Moore, Luiza, Leongamornlert, Daniel, Coorens, Tim H. H., Sanders, Mathijs A., Ellis, Peter, Dentro, Stefan C., Dawson, Kevin J., Butler, Tim, Rahbari, Raheleh, Mitchell, Thomas J., Maura, Francesco, Nangalia, Jyoti, Tarpey, Patrick S., Brunner, Simon F., Lee-Six, Henry, Hooks, Yvette, Moody, Sarah, Mahbubani, Krishnaa T., Jimenez-Linan, Mercedes, Brosens, Jan J., Iacobuzio-Donahue, Christine A., Martincorena, Inigo, Saeb-Parsy, Kourosh, Campbell, Peter J., Stratton, Michael R.

“…All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal…”
Get full text

Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial by Reyman, Marta, van Houten, Marlies A., Watson, Rebecca L., Chu, Mei Ling J. N., Arp, Kayleigh, de Waal, Wouter J., Schiering, Irene, Plötz, Frans B., Willems, Rob J. L., van Schaik, Willem, Sanders, Elisabeth A. M., Bogaert, Debby

“…Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of…”
Get full text

Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies by Slade, G.D., Ohrbach, R., Greenspan, J.D., Fillingim, R.B., Bair, E., Sanders, A.E., Dubner, R., Diatchenko, L., Meloto, C.B., Smith, S., Maixner, W.

“…In 2006, the OPPERA project (Orofacial Pain: Prospective Evaluation and Risk Assessment) set out to identify risk factors for development of painful…”
Get full text

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome by Stavropoulou, Vaia, Kaspar, Susanne, Brault, Laurent, Sanders, Mathijs A., Juge, Sabine, Morettini, Stefano, Tzankov, Alexandar, Iacovino, Michelina, Lau, I-Jun, Milne, Thomas A., Royo, Hélène, Kyba, Michael, Valk, Peter J.M., Peters, Antoine H.F.M., Schwaller, Juerg

“…To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9…”
Get full text

Adult neural stem cells in distinct microdomains generate previously unknown interneuron types by Merkle, Florian T, Fuentealba, Luis C, Sanders, Timothy A, Magno, Lorenza, Kessaris, Nicoletta, Alvarez-Buylla, Arturo

“…The authors report the generation of four previously unknown olfactory bulb interneuron subtypes by adult neural stem cells, organized into surprisingly small…”
Get full text

The role of the local microbial ecosystem in respiratory health and disease by de Steenhuijsen Piters, Wouter A. A., Sanders, Elisabeth A. M., Bogaert, Debby

“…Respiratory tract infections are a major global health concern, accounting for high morbidity and mortality, especially in young children and elderly…”
Get full text

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia by Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J., Adisty, Maria N., Van Strien, Paulina M.H., van der Leije, Cindy S., Westers, Theresia M., Cremers, Eline M.P., Milanese, Chiara, Mastroberardino, Pier G., van Leeuwen, Johannes P.T.M., van der Eerden, Bram C.J., Touw, Ivo P., Kuijpers, Taco W., Kanaar, Roland, van de Loosdrecht, Arjan A., Vogl, Thomas, Raaijmakers, Marc H.G.P.

“…Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and…”
Get full text

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia by Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud

“…Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic…”
Get full text

Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy by Sanders, Katherine A, Philp, Janet A C, Jordan, Crispin Y, Cale, Andrew S, Cunningham, Claire L, Organ, Jason M

“…Anatomy Nights is an international public engagement event created to bring anatomy and anatomists back to public spaces with the goal of increasing the…”
Get full text

Somatic Evolution in Non-neoplastic IBD-Affected Colon by Olafsson, Sigurgeir, McIntyre, Rebecca E., Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S., Lee-Six, Henry, Sanders, Mathijs A., Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R., Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J., Anderson, Carl A.

“…Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446…”
Get full text

Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life by Reyman, Marta, van Houten, Marlies A., van Baarle, Debbie, Bosch, Astrid A. T. M., Man, Wing Ho, Chu, Mei Ling J. N., Arp, Kayleigh, Watson, Rebecca L., Sanders, Elisabeth A. M., Fuentes, Susana, Bogaert, Debby

“…The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect…”
Get full text

Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children by Biesbroek, Giske, Tsivtsivadze, Evgeni, Sanders, Elisabeth A M, Montijn, Roy, Veenhoven, Reinier H, Keijser, Bart J F, Bogaert, Debby

“…Many bacterial pathogens causing respiratory infections in children are common residents of the respiratory tract. Insight into bacterial colonization patterns…”
Get full text

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes by Webber, J P, Spary, L K, Sanders, A J, Chowdhury, R, Jiang, W G, Steadman, R, Wymant, J, Jones, A T, Kynaston, H, Mason, M D, Tabi, Z, Clayton, A

“…Activation of myofibroblast rich stroma is a rate-limiting step essential for cancer progression. The responsible factors are not fully understood, but TGFβ1…”
Get full text