Search Results - "Sandercock, Peter A G"

Oral antiplatelet therapy for acute ischaemic stroke by Sandercock, Peter A G, Counsell, Carl, Tseng, Mei-Chiun, Cecconi, Emanuela

“…In people with acute ischaemic stroke, platelets become activated and can cause blood clots to form and block an artery in the brain, resulting in damage to…”
Get more information

Experiences of the Data Monitoring Committee for the RECOVERY trial, a large-scale adaptive platform randomised trial of treatments for patients hospitalised with COVID-19 by Sandercock, Peter A G, Darbyshire, Janet, DeMets, David, Fowler, Robert, Lalloo, David G, Munavvar, Mohammed, Staplin, Natalie, Warris, Adilia, Wittes, Janet, Emberson, Jonathan R

“…To inform the oversight of future clinical trials during a pandemic, we summarise the experiences of the Data Monitoring Committee (DMC) for the Randomised…”
Get full text

Fatigue after stroke: baseline predictors and influence on survival. Analysis of data from UK patients recruited in the International Stroke Trial by Mead, Gillian E, Graham, Catriona, Dorman, Paul, Bruins, Slot Karsten, Lewis, Steff C, Dennis, Martin S, Sandercock, Peter A G

“…Little is known about the associations of post-stroke fatigue or its influence on survival. The vitality component of the Short Form 36 (SF-36) is a valid and…”
Get full text

Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials by Whiteley, William N, Dr, Adams, Harold P, MD, Bath, Philip MW, FRCP, Berge, Eivind, MD, Sandset, Per Morten, MD, Dennis, Martin, MD, Murray, Gordon D, PhD, Wong, Ka-Sing Lawrence, MD, Sandercock, Peter AG, MD

“…Summary Background Many international guidelines on the prevention of venous thromboembolism recommend targeting heparin treatment at patients with stroke who…”
Get full text

Effect of X-Ray Attenuation of Arterial Obstructions on Intravenous Thrombolysis and Outcome after Ischemic Stroke by Mair, Grant, von Kummer, Rüdiger, Lindley, Richard I, Sandercock, Peter A G, Wardlaw, Joanna M

“…To assess whether the x-ray attenuation of intra-arterial obstruction measured on non-contrast CT in ischemic stroke can predict response to thrombolysis and…”
Get full text

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial by Al-Shahi Salman, Rustam, Murray, Gordon D, Dennis, Martin S, Newby, David E, Sandercock, Peter A G, Sprigg, Nikola, Sudlow, Cathie L M, Werring, David J, White, Philip M, Whiteley, William N

“…For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or…”
Get full text

Observer reliability of CT angiography in the assessment of acute ischaemic stroke: data from the Third International Stroke Trial by Mair, Grant, von Kummer, Rüdiger, Adami, Alessandro, White, Philip M., Adams, Matthew E., Yan, Bernard, Demchuk, Andrew M., Farrall, Andrew J., Sellar, Robin J., Ramaswamy, Rajesh, Mollison, Daisy, Boyd, Elena V., Rodrigues, Mark A., Samji, Karim, Baird, Andrew J., Cohen, Geoff, Sakka, Eleni, Palmer, Jeb, Perry, David, Lindley, Richard, Sandercock, Peter A. G., Wardlaw, Joanna M.

“…Introduction CT angiography (CTA) is often used for assessing patients with acute ischaemic stroke. Only limited observer reliability data exist. We tested…”
Get full text

Anticoagulants for acute ischaemic stroke by Sandercock, Peter A G, Counsell, Carl, Kane, Edward J

“…Most ischaemic strokes are caused by a blood clot blocking an artery in the brain. Clot prevention with anticoagulants might improve outcomes if bleeding risks…”
Get more information

The International Stroke Trial database by Sandercock, Peter A G, Niewada, Maciej, Członkowska, Anna

“…We aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke,…”
Get full text

Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial Index: A Randomized Controlled Trial by Fowkes, F. Gerald R, Price, Jacqueline F, Stewart, Marlene C. W, Butcher, Isabella, Leng, Gillian C, Pell, Alistair C. H, Sandercock, Peter A. G, Fox, Keith A. A, Lowe, Gordon D. O, Murray, Gordon D, Aspirin for Asymptomatic Atherosclerosis Trialists, for the

“…CONTEXT A low ankle brachial index (ABI) indicates atherosclerosis and an increased risk of cardiovascular and cerebrovascular events. Screening for a low ABI…”
Get full text

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial by Al-Shahi Salman, Rustam, Dennis, Martin S, Sandercock, Peter A G, Sudlow, Cathie L M, Wardlaw, Joanna M, Whiteley, William N, Murray, Gordon D, Stephen, Jacqueline, Rodriguez, Aryelly, Lewis, Steff, Werring, David J, White, Phil M

“…The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage…”
Get more information

Diffusion-weighted imaging and diagnosis of transient ischemic attack by Brazzelli, Miriam, Chappell, Francesca M., Miranda, Hector, Shuler, Kirsten, Dennis, Martin, Sandercock, Peter A. G., Muir, Keith, Wardlaw, Joanna M.

“…Objective Magnetic resonance (MR) diffusion‐weighted imaging (DWI) is sensitive to small acute ischemic lesions and might help diagnose transient ischemic…”
Get full text

Cochrane review on the role of surgery in cervical spondylotic radiculomyelopathy by FOUYAS, Loannis P, STATHAM, Patrick F. X, SANDERCOCK, Peter A. G

“…This study involved a search of MEDLINE (1966 to 2000), EMBASE (1980 to 2000), and the Cochrane Controlled Trials Register. The authors of the identified…”
Get full text

Antiplatelet therapy for acute ischaemic stroke by Sandercock, Peter A G, Counsell, Carl, Gubitz, Gordon J, Tseng, Mei-Chiun

“…In patients with acute ischaemic stroke, platelets become activated. Antiplatelet therapy might reduce the volume of brain damaged by ischaemia and reduce the…”
Get more information

Controversies in Thrombolysis by Sandercock, Peter A. G., Ricci, Stefano

“…Purpose of Review The purpose of the review is to examine recent evidence on the effects of intravenous thrombolysis and identify the remaining uncertainties…”
Get full text

Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial by Berge, Eivind, Prof, Cohen, Geoffrey, MSc, Roaldsen, Melinda B, MD, Lundström, Erik, MD, Isaksson, Eva, BN, Rudberg, Ann-Sofie, MD, Slot, Karsten Bruins, MD, Forbes, John, Prof, Smith, Joel, PhD, Drever, Jonathan, BSc, Wardlaw, Joanna M, Prof, Lindley, Richard I, Prof, Sandercock, Peter A G, Prof, Whiteley, William N, MD

“…Summary Background The effect of alteplase on patient survival after ischaemic stroke is the subject of debate. We report the effect of intravenous alteplase…”
Get full text

Clinical scores for the identification of stroke and transient ischaemic attack in the emergency department: a cross-sectional study by Whiteley, William N, Wardlaw, Joanna M, Dennis, Martin S, Sandercock, Peter A G

“…ObjectiveTo compare the sensitivity and specificity of bedside diagnostic stroke scales in patients with suspected stroke.DesignA cross-sectional observational…”
Get full text

Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis by Sena, Emily S, Briscoe, Catherine L, Howells, David W, Donnan, Geoffrey A, Sandercock, Peter AG, Macleod, Malcolm R

“…Thrombolysis with recombinant tissue plasminogen activator (rtPA) improves outcome in animal models of stroke and in clinical trial, but is associated with…”
Get full text

Surgery for cervical radiculopathy or myelopathy by Nikolaidis, Ioannis, Fouyas, Ioannis P, Sandercock, Peter Ag, Statham, Patrick F

“…Cervical spondylosis causes pain and disability by compressing the spinal cord or roots. Surgery to relieve the compression may reduce the pain and disability,…”
Get more information

A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full by Gibson, Lorna M, Brazzelli, Miriam, Thomas, Brenda M, Sandercock, Peter A G

“…We assessed the prevalence, and potential impact of, trials of pharmacological agents for acute stroke that were completed but not published in full. Failure…”
Get full text