Search Results - "Sandbaumhüter, Friederike A."

Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling by Sandbaumhüter, Friederike A., Nezhyva, Mariya, Andrén, Per E., Jansson, Erik T.

“…Thermal proteome profiling with label-free quantitation using ion-mobility-enhanced LC–MS offers versatile data sets, providing information on protein…”
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Effects of medetomidine and its active enantiomer dexmedetomidine on N‐demethylation of ketamine in canines determined in vitro using enantioselective capillary electrophoresis by Sandbaumhüter, Friederike A, Theurillat, Regula, Thormann, Wolfgang

“…Cytochrome P450 (CYP) enzymes catalyze the metabolism of both, the analgesic and anesthetic drug ketamine and the α₂‐adrenergic receptor‐agonist medetomidine…”
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Well-Plate μFASP for Proteomic Analysis of Single Pancreatic Islets by Sandbaumhüter, Friederike A, Nezhyva, Mariya, Eriksson, Olle, Engberg, Adam, Kreuger, Johan, Andrén, Per E, Jansson, Erik T

“…Filter-aided sample preparation (FASP) is widely used in bottom-up proteomics for tryptic digestion. However, the sample recovery yield of this method is…”
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Inquiry-based Learning of Proteomics and Metabolomics by Nezhyva, Mariya, Aerts, Jordan T., Sandbaumhüter, Friederike A., Vallianatou, Theodosia, Jansson, Erik T.

“…Given the rapid development of data-driven experimental procedures within the life sciences, it is important to equip students with proper skills and knowledge…”
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RNA interactome capture in Escherichia coli globally identifies RNA-binding proteins by Stenum, Thomas Søndergaard, Kumar, Ankith D, Sandbaumhüter, Friederike A, Kjellin, Jonas, Jerlström-Hultqvist, Jon, Andrén, Per E, Koskiniemi, Sanna, Jansson, Erik T, Holmqvist, Erik

“…Abstract RNA-binding proteins (RPBs) are deeply involved in fundamental cellular processes in bacteria and are vital for their survival. Despite this, few…”
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Fundamental aspects of field-amplified electrokinetic injection of cations for enantioselective capillary electrophoresis with sulfated cyclodextrins as selectors by Šesták, Jozef, Theurillat, Regula, Sandbaumhüter, Friederike A., Thormann, Wolfgang

“…•Field-amplified electrokinetic injection of cationic enantiomers is described.•Effects of a negatively charged chiral selector on injection are…”
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A6095 Drug adherence during laboratory workup for secondary hypertension by Bohlender, Jurgen, Sandbaumhüter, Friederike A, Vogt, Bruno, Haschke, Manuel

“…OBJECTIVES:Incompatible drugs should to be stopped before the laboratory workup for secondary hypertension. We performed plasma drug screening to check, if…”
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Effect of the α2‐receptor agonists medetomidine, detomidine, xylazine, and romifidine on the ketamine metabolism in equines assessed with enantioselective capillary electrophoresis by Sandbaumhüter, Friederike A., Theurillat, Regula, Bettschart‐Wolfensberger, Regula, Thormann, Wolfgang

“…The combination of ketamine and an α2‐receptor agonist is often used in veterinary medicine. Four different α2‐receptor agonists, medetomidine, detomidine,…”
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Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis by Sandbaumhüter, Friederike A., Vimercati, Sara, Thormann, Wolfgang, Mevissen, Meike

“…The anesthetic ketamine is often combined with analgesics and benzodiazepines in equine medicine. Therefore, drug-drug interactions are possible. Enzyme…”
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Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro by Sandbaumhüter, Friederike A., Thormann, Wolfgang

“…Glucuronidation catalyzed by uridine‐5′‐diphospho‐glucuronosyl‐transferases (UGTs) is the most important reaction in phase II metabolism of drugs and other…”
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Microassay for ketamine and metabolites in plasma and serum based on enantioselective capillary electrophoresis with highly sulfated γ-cyclodextrin and electrokinetic analyte injection by Theurillat, Regula, Sandbaumhüter, Friederike A., Bettschart-Wolfensberger, Regula, Thormann, Wolfgang

“…For the assessment of stereoselective aspects of the metabolism of ketamine, an enantioselective CE‐based microassay for determination of the stereoisomers of…”
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Enantioselective CE–MS analysis of ketamine metabolites in urine by Sandbaumhüter, Friederike A., Aerts, Jordan T., Theurillat, Regula, Andrén, Per E., Thormann, Wolfgang, Jansson, Erik T.

“…The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression…”
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Separation of hydroxynorketamine stereoisomers using capillary electrophoresis with sulfated β‐cyclodextrin and highly sulfated γ‐cyclodextrin by Sandbaumhüter, Friederike A., Theurillat, Regula, Thormann, Wolfgang

“…The racemic N‐methyl‐d‐aspartate receptor antagonist ketamine is used in anesthesia, analgesia and the treatment of depressive disorders. It is known that…”
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Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane by Theurillat, Regula, Sandbaumhüter, Friederike A., Gittel, Claudia, Larenza Menzies, M. Paula, Braun, Christina, Thormann, Wolfgang

“…An enantioselective assay for the determination of methadone and its main metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine in equine plasma based…”
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Effect of the α 2 -receptor agonists medetomidine, detomidine, xylazine, and romifidine on the ketamine metabolism in equines assessed with enantioselective capillary electrophoresis by Sandbaumhüter, Friederike A, Theurillat, Regula, Bettschart-Wolfensberger, Regula, Thormann, Wolfgang

“…The combination of ketamine and an α -receptor agonist is often used in veterinary medicine. Four different α -receptor agonists, medetomidine, detomidine,…”
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Stereoselective methadone disposition after administration of racemic methadone to anesthetized Shetland ponies assessed by capillary electrophoresis by Sandbaumhüter, Friederike A., Gittel, Claudia, Larenza‐Menzies, M. Paula, Theurillat, Regula, Thormann, Wolfgang, Braun, Christina

“…The enantioselectivity of the pharmacokinetics of methadone was investigated in anesthetized Shetland ponies after a single intravenous (0.5 mg/kg methadone…”
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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide by Rofo, Fadi, Sandbaumhüter, Friederike A, Chourlia, Aikaterini, Metzendorf, Nicole G, Morrison, Jamie I, Syvänen, Stina, Andrén, Per E, Jansson, Erik T, Hultqvist, Greta

“…Alzheimer’s disease is the most common neurodegenerative disorder characterized by the pathological aggregation of amyloid-β (Aβ) peptide. A potential…”
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Simulation and experimental study of enzyme and reactant mixing in capillary electrophoresis based on-line methods by Pelcová, Marta, Řemínek, Roman, Sandbaumhüter, Friederike A., Mosher, Richard A., Glatz, Zdeněk, Thormann, Wolfgang

“…•Computer simulation provides insight into reactant mixing during plug injection.•Electrophoretic mixing of reactants and enzyme after plug injection is…”
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Pharmacokinetics of ketamine and three metabolites in Beagle dogs under sevoflurane vs. medetomidine comedication assessed by enantioselective capillary electrophoresis by Sandbaumhüter, Friederike A., Theurillat, Regula, Bektas, Rima N., Kutter, Annette P.N., Bettschart-Wolfensberger, Regula, Thormann, Wolfgang

“…•Stereoisomers of ketamine and metabolites analyzed by enantioselective CE.•Metabolite levels of norketamine, 6-hydroxynorketamine and…”
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Medication adherence during laboratory workup for primary aldosteronism: pilot study by Sandbaumhüter, Friederike A, Haschke, Manuel, Vogt, Bruno, Bohlender, Jürgen M

“…Current hypertension guidelines stipulate that all incompatible medications be stopped before performing laboratory screening for aldosteronism, but patient…”
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