Search Results - "Sandanayaka, V."

974 Selective Inhibitors of Nuclear Export (SINE) CRM1 (XPO1) Antagonists Activate Multiple Tumor Suppressor Pathways and Kill Prostate Cancer (PrCa) Cells by Festuccia, C, Gravina, G.L, Mancini, A, D'Alessandro, A, Chin, L, Shechter, S, Sandanayaka, V, McCauley, D, Kauffman, M, Shacham, S

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Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates by Levin, J.I., Chen, J.M., Laakso, L.M., Du, M., Du, X., Venkatesan, A.M., Sandanayaka, V., Zask, A., Xu, J., Xu, W., Zhang, Y., Skotnicki, J.S.

“…The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1′ group was explored. In particular, compound 5k has excellent in…”
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Resistance to beta-lactam antibiotics: structure and mechanism based design of beta-lactamase inhibitors by Sandanayaka, Vincent P, Prashad, Amar S

“…Resistance to antibiotics is currently a major health concern in treating infectious diseases. The most common mechanism of resistance to beta-lactam…”
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Cellular transporters as novel metabolic immune checkpoints: NGY-091, a small molecule dual MCT1/4 inhibitor for immuno oncology by Sandanayaka, V., Sharma, S., Bowman, N., Duffy, J., Wijerathna, S., Yu, M., Escobedo, J., Kuklin, N.

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Dipolar Cycloaddition of Novel 6-(Nitrileoxidomethyl) Penam Sulfone:  An Efficient Route to a New Class of β-Lactamase Inhibitors by Sandanayaka, Vincent P, Yang, Youjun

“…6-(Nitrileoxidomethyl) penam sulfone intermediate was prepared in a few steps starting from commercially available (+)-6-aminopenicillanic acid. This…”
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Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new β-lactamase inhibitors by Sandanayaka, Vincent P., Feigelson, Gregg B., Prashad, Amar S., Yang, Youjun, Petersen, Peter J.

“…Several alkenyl derivatives were prepared using allyl penam sulfone as the key intermediate. Isomers of these derivatives having β configuration at C-6 showed…”
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Cytotoxicity of novel, small molecule, CRM1-selective inhibitors of nuclear export (SINE) in colorectal cancer (CRC) cells by Draetta, G. F., Shacham, S., Kauffman, M., Sandanayaka, V., Schechter, S., Williams, J., Nir, R.

“…Abstract only…”
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Preclinical development of small-molecule CRM1 inhibitors as novel therapy for the treatment of colorectal cancer (CRC) by Shacham, S., Kauffman, M., Sandanayaka, V., Draetta, G., Shechter, S., Williams, J., Nir, R.

“…Abstract only 430 Background: CRM1 (XPO1) is a key nuclear export protein which controls the location of multiple tumor suppressor (TSP) and growth regulatory…”
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Spirocyclopropyl β-Lactams as Mechanism-Based Inhibitors of Serine β-Lactamases. Synthesis by Rhodium-Catalyzed Cyclopropanation of 6-Diazopenicillanate Sulfone by Sandanayaka, Vincent P, Prashad, Amar S, Yang, Youjun, Williamson, R. Thomas, Lin, Yang I, Mansour, Tarek S

“…Class A−class C mechanism-based β-lactamase inhibitors were designed on the basis of the intermediacy of an oxycarbenium species capable of cross-linking with…”
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Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis by Aranapakam, Venkatesan, Davis, Jamie M, Grosu, George T, Baker, Ellingboe, John, Zask, Arie, Levin, Jeremy I, Sandanayaka, Vincent P, Du, Mila, Skotnicki, Jerauld S, DiJoseph, John F, Sung, Amy, Sharr, Michele A, Killar, Loran M, Walter, Thomas, Jin, Guixian, Cowling, Rebecca, Tillett, Jeff, Zhao, Weiguang, McDevitt, Joseph, Xu, Zhang Bao

“…The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue…”
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An Approach toward the Illudin Family of Sesquiterpenes Using the Tandem Cyclization−Cycloaddition Reaction of Rhodium Carbenoids by Padwa, Albert, Curtis, Erin A, Sandanayaka, Vincent P

“…The Rh(II)-catalyzed reaction of 1-acetyl-1-(diazoacetyl)cyclopropane with 5,5-dimethylcyclopentenone afforded the product of a 1,3-dipolar cycloaddition in…”
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Synthetic studies toward Illudins and Ptaquilosin. A highly convergent approach via the dipolar cycloaddition of carbonyl ylides by Padwa, Albert, Sandanayaka, Vincent P, Curtis, Erin A

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An efficient method to prepare α-sulfonyl hydroxamic acid derivatives by Sandanayaka, Vincent P, Zask, Arie, Venkatesan, Aranapakam M, Baker, Jannie

“…α-Sulfonyl hydroxamic acid derivatives are biologically important molecules. An efficient protocol has been developed to make these molecules via a direct…”
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Generation and Cycloaddition Behavior of Spirocyclic Carbonyl Ylides. Application to the Synthesis of the Pterosin Family of Sesquiterpenes by Padwa, Albert, Curtis, Erin A, Sandanayaka, Vincent P

“…The Rh(II)-catalyzed reaction of 1-acetyl-1-(diazoacetyl)cyclopropane and ethyl 3-(1-acetyl-cyclopropyl)-2-diazo-3-oxopropiolate with various dipolarophiles…”
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An efficient dipolar-cycloaddition route to the pterosin family of sesquiterpenes by Curtis, Erin A., Sandanayaka, Vincent P., Padwa, Albert

“…A short synthesis of several members of the pterosin family of sesquiterpenes is described in which the key step involves a dipolar-cycloaddition using a…”
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Studies on Intramolecular Higher-Order Cycloaddition Reactions by Rigby, James H, Rege, Sushil D, Sandanayaka, Vincent P, Kirova, Margarita

“…Thermal, metal-free, and metal-promoted intramolecular higher-order cycloadditions are described. Substrates in which the tropone (2,4,6-cycloheptatrien-1-one)…”
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