Search Results - "Sandén, Carl"

IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1 -positive leukemia cells in preclinical models by Ågerstam, Helena, Lilljebjörn, Henrik, Rissler, Marianne, Sandén, Carl, Fioretos, Thoas

Get full text

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models by Ågerstam, Helena, Hansen, Nils, von Palffy, Sofia, Sandén, Carl, Reckzeh, Kristian, Karlsson, Christine, Lilljebjörn, Henrik, Landberg, Niklas, Askmyr, Maria, Högberg, Carl, Rissler, Marianne, Porkka, Kimmo, Wadenvik, Hans, Mustjoki, Satu, Richter, Johan, Järås, Marcus, Fioretos, Thoas

“…Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a…”
Get full text

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia by Ågerstam, Helena, Karlsson, Christine, Hansen, Nils, Sandén, Carl, Askmyr, Maria, von Palffy, Sofia, Högberg, Carl, Rissler, Marianne, Wunderlich, Mark, Juliusson, Gunnar, Richter, Johan, Sjöström, Kjell, Bhatia, Ravi, Mulloy, James C., Järås, Marcus, Fioretos, Thoas

“…Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML…”
Get full text

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations by Subramaniam, Agatheeswaran, Sandén, Carl, Moura-Castro, Larissa, Žemaitis, Kristijonas, Schmiderer, Ludwig, Baudet, Aurelie, Bäckström, Alexandra, Arvidsson, Elin, Hultmark, Simon, Miharada, Natsumi, Magnusson, Mattias, Paulsson, Kajsa, Fioretos, Thoas, Larsson, Jonas

Get full text

Clonal competition within complex evolutionary hierarchies shapes AML over time by Sandén, Carl, Lilljebjörn, Henrik, Orsmark Pietras, Christina, Henningsson, Rasmus, Saba, Karim H., Landberg, Niklas, Thorsson, Hanna, von Palffy, Sofia, Peña-Martinez, Pablo, Högberg, Carl, Rissler, Marianne, Gisselsson, David, Lazarevic, Vladimir, Juliusson, Gunnar, Ågerstam, Helena, Fioretos, Thoas

“…Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in…”
Get full text

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases by Thorsson, Hanna, Henningsson, Rasmus, Puente-Moncada, Noelia, Peña-Martínez, Pablo, Sjöström, Ludvig, Ågerstam, Helena, Sandén, Carl, Rissler, Marianne, Castor, Anders, Marquart, Hanne, Modvig, Signe, Paulsson, Kajsa, Pronk, Cornelis Jan, Schmiegelow, Kjeld, Hyrenius-Wittsten, Axel, Orsmark-Pietras, Christina, Lilljebjörn, Henrik, Fioretos, Thoas

“…•Single-cell multiomics delineates the maturation block in childhood ALL with DUX4-r cases exhibiting a high degree of lineage infidelity.•DUX4-r ALL displays…”
Get full text

A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells by von Palffy, Sofia, Landberg, Niklas, Sandén, Carl, Zacharaki, Dimitra, Shah, Mansi, Nakamichi, Naoto, Hansen, Nils, Askmyr, Maria, Lilljebjörn, Henrik, Rissler, Marianne, Karlsson, Christine, Scheding, Stefan, Richter, Johan, Eaves, Connie J, Bhatia, Ravi, Järås, Marcus, Fioretos, Thoas

“…Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem…”
Get full text

Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells by Hultmark, Simon, Baudet, Aurélie, Schmiderer, Ludwig, Prabhala, Pavan, Palma-Tortosa, Sara, Sandén, Carl, Fioretos, Thoas, Sasidharan, Rajkumar, Larsson, Christer, Lehmann, Sören, Juliusson, Gunnar, Ek, Fredrik, Magnusson, Mattias

“…Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components…”
Get full text

Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR by Sandén, Carl, Ageberg, Malin, Petersson, Jessica, Lennartsson, Andreas, Gullberg, Urban

“…The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with…”
Get full text

Transcriptional profiling demonstrates altered characteristics of CD8+ cytotoxic T‐cells and regulatory T‐cells in TP53‐mutated acute myeloid leukemia by Abolhalaj, Milad, Sincic, Viktor, Lilljebjörn, Henrik, Sandén, Carl, Aab, Alar, Hägerbrand, Karin, Ellmark, Peter, Borrebaeck, Carl A. K., Fioretos, Thoas, Lundberg, Kristina

“…Background Acute myeloid leukemia (AML) patients have limited effect from T‐cell‐based therapies, such as PD‐1 and CTLA‐4 blockade. However, recent data…”
Get full text

Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells by Ullmark, Tove, Järvstråt, Linnea, Sandén, Carl, Montano, Giorgia, Jernmark-Nilsson, Helena, Lilljebjörn, Henrik, Lennartsson, Andreas, Fioretos, Thoas, Drott, Kristina, Vidovic, Karina, Nilsson, Björn, Gullberg, Urban

“…The zinc finger transcription factor Wilms tumor gene 1 (WT1) acts as an oncogene in acute myeloid leukemia. A naturally occurring alternative splice event…”
Get full text

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting by Landberg, Niklas, von Palffy, Sofia, Askmyr, Maria, Lilljebjörn, Henrik, Sandén, Carl, Rissler, Marianne, Mustjoki, Satu, Hjorth-Hansen, Henrik, Richter, Johan, Ågerstam, Helena, Järås, Marcus, Fioretos, Thoas

“…Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major…”
Get full text

The DEK oncoprotein is upregulated by multiple leukemia-associated fusion genes by Sandén, Carl, Nilsson, Helena Jernmark, Gullberg, Urban

Get full text

The complement receptor C3AR constitutes a novel therapeutic target in NPM1-mutated AML by von Palffy, Sofia, Thorsson, Hanna, Peña-Martínez, Pablo, Puente-Moncada, Noelia, Sandén, Carl, Blom, Anna M., Henningsson, Rasmus, Juliusson, Gunnar, King, Ben, Landberg, Niklas, Lazarevic, Vladimir, Orsmark-Pietras, Christina, Rissler, Marianne, Rissler, Vendela, Ågerstam, Helena, Järås, Marcus, Lilljebjörn, Henrik, Fioretos, Thoas

“…•C3AR is selectively expressed on NPM1-mutated primary AML cells compared to both NPM1 wild type cases and normal hematopoietic stem cells.•The C3a/C3AR…”
Get full text

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation by Sandén, Carl, Järvstråt, Linnea, Lennartsson, Andreas, Brattås, Per Ludvik, Nilsson, Björn, Gullberg, Urban

“…The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been…”
Get full text

The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G by Petersson, Jessica, Ageberg, Malin, Sandén, Carl, Olofsson, Tor, Gullberg, Urban, Drott, Kristina

“…Background information The interferon (IFN)‐inducible protein TRIM22 (Staf50) is a member of the tripartite motif protein family and has been suggested a role…”
Get full text

The DEK oncoprotein and its emerging roles in gene regulation by Sandén, C, Gullberg, U

“…The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214…”
Get full text

Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4-Rearranged ALL by Thorsson, Hanna, Henningsson, Rasmus, Puente-Moncada, Noelia, Sandén, Carl, Modvig, Signe, Rissler, Marianne, Paulsson, Kajsa, Castor, Anders, Pronk, Cornelis Jan, Marquart, Hanne Vibeke, Schmiegelow, Kjeld, Orsmark-Pietras, Christina, Lilljebjörn, Henrik, Fioretos, Thoas

Get full text

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4-Rearranged Cases by Thorsson, Hanna, Henningsson, Rasmus, Puente-Moncada, Noelia, Sjöström, Ludvig, Ågerstam, Helena, Peña-Martínez, Pablo Enrique, Sandén, Carl, Rissler, Marianne, Castor, Anders, Marquart, Hanne Vibeke, Modvig, Signe, Paulsson, Kajsa, Pronk, Cornelis, Schmiegelow, Kjeld, Hyrenius Wittsten, Axel, Orsmark-Pietras, Christina, Lilljebjörn, Henrik PhD, Fioretos, Thoas

“…B cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy. It is initiated by multiple genetic alterations, causing a…”
Get full text

Combinatorial molecule screening identifies a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells by Hultmark, Simon, Baudet, Aurélie, Schmiderer, Ludwig, Prabhala, Pavan, Palma-Tortosa, Sara, Sandén, Carl, Fioretos, Thoas, Sasidharan, Rajkumar, Larsson, Christer, Lehmann, Sören, Juliusson, Gunnar, Ek, Fredrik, Magnusson, Mattias

“…Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components…”
Get full text