Search Results - "Sand, Kine M. K."

The Neonatal Fc Receptor (FcRn): A Misnomer? by Pyzik, Michal, Sand, Kine M K, Hubbard, Jonathan J, Andersen, Jan Terje, Sandlie, Inger, Blumberg, Richard S

“…Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and…”
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A human endothelial cell-based recycling assay for screening of FcRn targeted molecules by Grevys, Algirdas, Nilsen, Jeannette, Sand, Kine M. K., Daba, Muluneh B., Øynebråten, Inger, Bern, Malin, McAdam, Martin B., Foss, Stian, Schlothauer, Tilman, Michaelsen, Terje E., Christianson, Gregory J., Roopenian, Derry C., Blumberg, Richard S., Sandlie, Inger, Andersen, Jan Terje

“…Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular…”
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Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T‐cell activation by Wälchli, Sébastien, Kumari, Shraddha, Fallang, Lars‐Egil, Sand, Kine M. K., Yang, Weiwen, Landsverk, Ole J. B., Bakke, Oddmund, Olweus, Johanna, Gregers, Tone F.

“…Protective T‐cell responses depend on efficient presentation of antigen (Ag) in the context of major histocompatibility complex class I (MHCI) and class II…”
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FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity by Hubbard, Jonathan J, Pyzik, Michal, Rath, Timo, Kozicky, Lisa K, Sand, Kine M K, Gandhi, Amit K, Grevys, Algirdas, Foss, Stian, Menzies, Susan C, Glickman, Jonathan N, Fiebiger, Edda, Roopenian, Derry C, Sandlie, Inger, Andersen, Jan Terje, Sly, Laura M, Baker, Kristi, Blumberg, Richard S

“…IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa…”
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Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling by Merten, Hannes, Brandl, Fabian, Zimmermann, Martina, Schaefer, Jonas V., Irpinio, Linda, Sand, Kine M.K., Nilsen, Jeannette, Andersen, Jan Terje, Zangemeister-Wittke, Uwe, Plückthun, Andreas

“…[Display omitted] Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recycling and has been used for half-life…”
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